A5056143565- Amoebic Infections and Treatments
- Parasites and Host Interactions
- Trypanosoma species research and implications
- Parasitic Infections and Diagnostics
- Immune Response and Inflammation
- Immune cells in cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Pancreatitis Pathology and Treatment
- Reproductive System and Pregnancy
- Research on Leishmaniasis Studies
- Liver Disease and Transplantation
- Neonatal Health and Biochemistry
- Diagnosis and treatment of tuberculosis
- Macrophage Migration Inhibitory Factor
Bernhard Nocht Institute for Tropical Medicine
2018-2023
Abstract Hepatic amebiasis, predominantly occurring in men, is a focal destruction of the liver due to invading protozoan Entamoeba histolytica . Classical monocytes as well testosterone are identified have important functions for development hepatic amebiasis mice, but link between and has not been identified. Here we show that treatment induces proinflammatory responses human mouse classical monocytes. When treated with 5α-dihydrotestosterone, strong androgen receptor ligand, increase...
Differences in immune response between men and women may influence the outcome of infectious diseases. Intestinal infection with Entamoeba histolytica leads to hepatic amebiasis, which is more common males. Previously, we reported that innate cells contribute liver damage males murine model for amebiasis. Here, focused on influences sex androgens neutrophils particular. Infection associated neutrophil accumulation was higher male than female mice further increased after testosterone...
An invasive form of intestinal Entamoeba (E.) histolytica infection, which causes amoebic liver abscess, is more common in men than women. Immunopathological mechanisms are responsible for the severe outcome males. Here, we used a mouse model hepatic amoebiasis to investigate contribution hypoxia-inducible factor (HIF)-1α T helper 17 (Th17)/regulatory cell (Treg) responses context sex-specific damage.C57BL/6J mice were infected intrahepatically with E. trophozoites. HIF-1α expression was...
In the past, proinflammatory CD11b+Ly6Chi monocytes were predominantly considered as a uniform population. However, recent investigations suggests that this population is far more diverse than previously thought. For example, in mouse models of Entamoeba (E.) histolytica and Listeria (L.) monocytogenes liver infections, it was shown their absence had opposite effects. former model, ameliorated parasite-dependent injury, whereas listeria model exacerbated pathology. Here, we analyzed Ly6Chi...
With an estimated number of new cases annually approximately 1.4 million, leishmaniasis belongs to the most important parasitic diseases in world. Nevertheless, existing drugs against general have several drawbacks that urgently necessitate drug development. A glycolipid molecule intestinal protozoan parasite Entamoeba histolytica and its synthetic analogs previously showed considerable immunotherapeutic effects Leishmania major infection. Here, we designed synthesized a series...