A5045108066- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Sleep and Wakefulness Research
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- Functional Brain Connectivity Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Memory Processes and Influences
- Liver physiology and pathology
- Axon Guidance and Neuronal Signaling
- Zebrafish Biomedical Research Applications
- Neural and Behavioral Psychology Studies
- Drug Transport and Resistance Mechanisms
- Receptor Mechanisms and Signaling
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Disease and Adiposity
- Neuroscience, Education and Cognitive Function
- Spatial Cognition and Navigation
- Obsessive-Compulsive Spectrum Disorders
- Stroke Rehabilitation and Recovery
- Nicotinic Acetylcholine Receptors Study
Cardiff University
2015-2024
Nelson Engineering (United States)
2022-2024
University of Nottingham
2004-2019
University of Bologna
2016
Children's Hospital of Philadelphia
2005-2014
Performance of instrumental actions in rats is initially sensitive to postconditioning changes reward value, but after more extended training, behavior comes be controlled by stimulus–response (S-R) habits that are no longer goal directed. To examine whether sensitization dopaminergic systems leads a rapid transition from action–outcome processes S-R habits, we examined performance amphetamine-sensitized an devaluation task. Animals were either sensitized (7 d, 2 mg/kg/d) before training...
Repeated exposure to the psychostimulant amphetamine has been shown disrupt goal-directed instrumental actions and promote early abnormal development of goal-insensitive habitual responding (Nelson Killcross, 2006). To investigate neuropharmacological specificity this effect as well restore in animals with pre-training exposure, were treated non-selective dopamine antagonist α-flupenthixol, selective D1 SCH 23390 or D2 eticlopride, prior training (three sessions). Subsequently, reinforcer...
The prefrontal cortex mediates adaption to changing environmental contingencies. anterior thalamic nuclei, which are closely interconnected with the cortex, important for rodent spatial memory, but their potential role in executive function has received scant attention. current study examined whether nuclei involved attentional processes akin those of regions. Remarkably, results repeatedly revealed properties opposite cortex. Two separate cohorts rats lesions were tested on an set-shifting...
The rodent retrosplenial cortex (RSC) functions as an integrative hub for sensory and motor signals, serving roles in both navigation memory. While RSC is reciprocally connected with the cortex, form which information represented how it interacts feedback unclear likely to be critical computations involved such path integration. Here, we used 2-photon cellular imaging of neural activity putative excitatory (CaMKII expressing) inhibitory (parvalbumin neurons measure visual locomotion evoked...
The hippocampus is essential for normal memory but does not act in isolation. anterior thalamic nuclei may represent one vital partner. Using DREADDs, the behavioral consequences of transiently disrupting function were examined, followed by inactivation dorsal subiculum. Next, anterograde transport an adeno-associated virus expressing DREADDs was paired with localized intracerebral infusions a ligand to target specific input pathways. In this way, direct projections from hippocampal...
The Notch signaling pathway is involved in determination of cell fate and control proliferation multiple organ systems. Jag1 encodes a ligand the has been identified as disease-causing gene for developmental disorder Alagille syndrome. Evidence from study human disease mouse models implicated having an important role development bile ducts. We have derived conditional knockout allele ( loxP) to liver duct development. crossed loxP mice with transgenic line carrying Cre recombinase under...
Abstract Alagille syndrome (AGS) is a heterogeneous developmental disorder associated with bile duct paucity and various organ anomalies. The caused by mutations in JAG1 , which encodes ligand the Notch signaling pathway, majority of cases NOTCH2 receptor gene less than 1% patients. Although wide array have been identified AGS population, these mutational variants not accounted for phenotypic variability observed patients this syndrome. Fringe genes encode glycosyltransferases, modify alter...
The present study examined the consequences of retrosplenial cortex lesions in rats on two novel spatial tasks. In first experiment, discriminated opposing room views from same general location, along with their directions travel ('Perspective' task). Rats were trained food rewards using a go/no-go design. Extensive involving both granular and dysgranular areas impaired acquisition this discrimination, which relied distal visual cues. then non-spatial discrimination between different digging...
It has been proposed that the retrosplenial cortex forms part of a 'where/when' information network. The present study focussed on related issue whether also contributes to 'what/when' information, by examining object recency memory. In Experiment 1, rats with lesions were found be impaired at distinguishing temporal order objects presented in continuous series ('Within-Block' condition). same lesioned could, however, distinguish between had previously one two discrete blocks...
By virtue of its frontal and hippocampal connections, the retrosplenial cortex is uniquely placed to support cognition. Here, we tested whether required for tasks analogous Stroop Test, i.e., ability select between conflicting responses inhibit responding task-irrelevant cues. Rats first acquired two instrumental conditional discriminations, one auditory visual, set in distinct contexts. As a result, rats were rewarded pressing either right or left lever when particular visual signal was...
There is good evidence that the medial prefrontal cortex (mPFC) involved in different aspects of recognition memory. However, mPFC a heterogeneous structure, and contribution prelimbic (PL) infralimbic (IL) cortices to memory has not been investigated. Similarly, role neuromodulators within these processes poorly understood. To this end, we tested animals with 6-hydroxydopamine (6-OHDA) lesions PL IL on three tests object required judgments about recency, location, identity. In recency task,...
Laboratory rats can exhibit marked, qualitative individual differences in the form of acquired behaviors. For example, when exposed to a signal-reinforcer relationship some show marked and consistent changes sign-tracking (interacting with signal; e.g., lever) others goal-tracking location predicted reinforcer; food well). Here, stable rats' emerged over course training, but these did not generalize across different relationships (Experiment 1). This selectivity suggests that sign- reflect...
The retrosplenial cortex supports navigation, with one role thought to be the integration of different spatial cue types. This hypothesis was extended by examining nonspatial cues. Rats lesions in either dysgranular subregion (area 30) or both granular and subregions (areas 29 were tested on cross-modal object recognition (Experiment 1). In these tests, rats used sensory modalities when exploring subsequently recognizing same test objects. objects first presented dark, i.e., giving tactile...
The retrosplenial cortex supports navigation, but there are good reasons to suppose that the has a very different role in spatial memory from of hippocampus and anterior thalamic nuclei. For example, lesions appear have little or no effect on standard tests alternation. To examine these differences, current study sought determine whether is important for just one cue type (e.g. allocentric, directional intra-maze cues) helps animal switch between competing strategies types. Using T-maze...
To understand the hippocampus, it is necessary to subiculum. Unlike other hippocampal subfields, subiculum projects almost all distal targets, highlighting its critical importance for external networks. The present studies, in male rats and mice, reveal a new category of dorsal neurons that innervate both mammillary bodies (MBs) retrosplenial cortex (RSP). These bifurcating comprise half cells project RSP. termination these numerous collateral projections was visualized within medial nucleus...