A5001661209- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Neuroendocrine regulation and behavior
- Memory Processes and Influences
- Spinal Cord Injury Research
- Stress Responses and Cortisol
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
University of Bristol
2022
Cardiff University
2014-2020
Ollscoil na Gaillimhe – University of Galway
2012-2014
Mental Health Research Institute
2014
This review brings together current knowledge from tract tracing studies to update and reconsider those limbic connections initially highlighted by Papez (1937) for their presumed role in emotion. These link hippocampal parahippocampal regions with the mammillary bodies, anterior thalamic nuclei, cingulate gyrus, all structures now strongly implicated memory functions. An additional goal of this is describe routes taken various within network. The original descriptions these saw...
The hippocampus is essential for normal memory but does not act in isolation. anterior thalamic nuclei may represent one vital partner. Using DREADDs, the behavioral consequences of transiently disrupting function were examined, followed by inactivation dorsal subiculum. Next, anterograde transport an adeno-associated virus expressing DREADDs was paired with localized intracerebral infusions a ligand to target specific input pathways. In this way, direct projections from hippocampal...
It has been proposed that the retrosplenial cortex forms part of a 'where/when' information network. The present study focussed on related issue whether also contributes to 'what/when' information, by examining object recency memory. In Experiment 1, rats with lesions were found be impaired at distinguishing temporal order objects presented in continuous series ('Within-Block' condition). same lesioned could, however, distinguish between had previously one two discrete blocks...
The use of multichannel polymer scaffolds in a complete spinal cord transection injury serves as deconstructed model that allows for control individual variables and direct observation their effects on regeneration. In this study, fabricated from positively charged oligo[poly(ethylene glycol)fumarate] (OPF+) hydrogel were implanted into rat cords following T9 transection. OPF+ scaffold channels loaded with either syngeneic Schwann cells or mesenchymal stem derived enhanced green fluorescent...
To understand the hippocampus, it is necessary to subiculum. Unlike other hippocampal subfields, subiculum projects almost all distal targets, highlighting its critical importance for external networks. The present studies, in male rats and mice, reveal a new category of dorsal neurons that innervate both mammillary bodies (MBs) retrosplenial cortex (RSP). These bifurcating comprise half cells project RSP. termination these numerous collateral projections was visualized within medial nucleus...
Perirhinal cortex provides object-based information and novelty/familiarity for the hippocampus. The necessity of these inputs was tested by comparing hippocampal c-fos expression in rats with or without perirhinal lesions. These either discriminated novel from familiar objects (Novel-Familiar) explored pairs (Novel-Novel). Despite impairing Novel-Familiar discriminations, lesions did not affect novelty detection, as measured overall object exploration levels (Novel-Novel condition). also...
Rats with perirhinal cortex lesions received multiple object recognition trials within a continuous session to examine whether they show false memories. Experiment 1 focused on exploration patterns during the first test postsurgery, in which each trial contained novel and familiar object. The reduced time spent exploring objects, but did not affect overall objects (novel plus familiar). Replications subsequent cohorts of rats (Experiments 2, 3, 4.1) repeated this pattern results. When all...
Abstract The present study examined immediate‐early gene expression in the perirhinal cortex of rats with hippocampal lesions. goal was to test those models recognition memory which assume that can function independently hippocampus. c‐ fos targeted, as its is strongly associated memory. Four groups were examined. Rats lesions and their surgical controls given either a task (novel vs. familiar objects) or relative recency (objects differing degrees familiarity). Perirhinal Fos...
The expression of the immediate-early gene c-fos was used to compare networks activity associated with recency memory (temporal order memory) and recognition memory.In Experiment 1, rats were first familiarized sets objects then given pairs different, familiar explore.For test group, each object in a pair separated by 110 min time between their previous presentations.For control test, less than 1 prior presentations.Temporal discrimination correlated group several sites, including area Te2,...
Background: In the rat brain, context information is thought to engage network interactions between postrhinal cortex, medial entorhinal and hippocampus. contrast, object be more reliant on perirhinal cortex lateral with Method: The ‘context network’ was explored by mapping expression of immediate-early gene, c- fos, after exposure a new spatial environment. Results: Structural equation modelling Fos counts produced networks good fit that closely matched prior predictions based anatomically...
The present study examined the effects of excitotoxic lesions in 2 closely related structures, anterior thalamic nuclei and retrosplenial cortex, on latent inhibition. Latent inhibition occurs when nonreinforced preexposure to a stimulus retards subsequent acquisition conditioned responding that stimulus. was assessed within-subject procedure with auditory stimuli food reinforcement. As expected, sham-operated animals were slower acquire had previously been experienced without consequence,...
The rodent anterior thalamic nuclei (ATN) are vital for spatial memory. A consideration of their extensive frontal connections suggests that these may also subserve non-spatial functions. current experiments explored the importance ATN different aspects behavioural flexibility, including contribution to tasks typically associated with cortex. In Experiment 1, rats lesions were tested on a series response and visual discriminations in an operant box and, subsequently, water tank. included...
Studying the physiological properties of specific synapses in brain, and how they undergo plastic changes, is a key challenge modern neuroscience. Traditional vitro electrophysiological techniques use electrical stimulation to evoke synaptic transmission. A major drawback this method its nonspecific nature; all axons region stimulating electrode will be activated, making it difficult attribute an effect particular afferent connection. This issue can overcome by replacing with...
Studying the physiological properties of specific synapses in brain, and how they undergo plastic changes, is a key challenge modern neuroscience. Traditional vitro electrophysiological techniques use electrical stimulation to evoke synaptic transmission. A major drawback this method its nonspecific nature; all axons region stimulating electrode will be activated, making it difficult attribute an effect particular afferent connection. This issue can overcome by replacing with...