A5024215031- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Animal Virus Infections Studies
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Malaria Research and Control
- vaccines and immunoinformatics approaches
- Viral gastroenteritis research and epidemiology
- Parasite Biology and Host Interactions
- Virus-based gene therapy research
- Vector-borne infectious diseases
- Helminth infection and control
- Zoonotic diseases and public health
- Mesenchymal stem cell research
- Congenital Diaphragmatic Hernia Studies
- HIV Research and Treatment
- Respiratory Support and Mechanisms
- Animal Nutrition and Physiology
- Poxvirus research and outbreaks
- Yersinia bacterium, plague, ectoparasites research
- Leptospirosis research and findings
- Identification and Quantification in Food
- Immunotherapy and Immune Responses
Universiti Putra Malaysia
2016-2025
Liverpool School of Tropical Medicine
2022
Universiti Malaysia Kelantan
2022
Universitas Wijaya Putra
2019
Research Institute for Bioscience and Biotechnology
2016
A high death rate among red hybrid tilapias was observed in a farm Selangor, Malaysia, January 2020. The affected fish appeared lethargic, isolated from schooling group, showed loss of appetite, and haemorrhagic skin, exophthalmia enlarged gall bladders. Histopathological assessment revealed deformation kidney tubules, severe congestion with infiltrations inflammatory cells the brains kidneys. Syncytial intracytoplasmic inclusion bodies were occasionally liver brain sections. Tilapia Lake...
Human umbilical cord mesenchymal stem cell-derived small extracellular vesicle (hUC-MSCs-sEVs) therapy has shown promising results to treat diabetes mellitus in preclinical studies. However, the dosage of MSCs-sEVs animal studies, up 10 mg/kg, was considered high and may be impractical for future clinical application. This study aims investigate efficacy low-dose hUC-MSCs-sEVs treatment on human skeletal muscle cells (HSkMCs) type 2 (T2DM) rats. Treatment with 100 μg/mL 48 h showed no...
Very virulent infectious bursal disease virus (vvIBDV) induces immunosuppression and inflammation in young birds, which subsequently leads to high mortality. In addition, (IBD) is one of the leading causes vaccine failure on farms. Therefore, understanding immunopathogenesis IBDV both spleen bursae could help effective development. However, previous studies only profiled differential expression a limited number cytokines, either or Fabricius IBDV-infected chickens. Thus, this study aims...
Japanese encephalitis (JE) is vector-borne zoonotic disease which causes in humans and horses. Clinical signs for virus (JEV) infection are not clearly evident the majority of affected animals. In Malaysia, information on prevalence JEV has been established. Thus, a cross-sectional study was conducted during two periods, December 2015 to January 2016 March August 2016, determine risk factors infections among animals birds Peninsular Malaysia. Serum samples were harvested from 416 collected...
Background and Aim: Infectious bursal disease (IBD) is an immunosuppressive caused by the IBD virus (IBDV), which adversely affects poultry vaccination programs. The novel variant IBDV (nvIBDV) has recently emerged in various regions, including Malaysia, raising concerns about its potential impact on Newcastle (ND) vaccination. This study aimed to investigate effects of Malaysian nvIBDV strain (UPM1432/2019) specific-pathogen-free (SPF) broiler chickens evaluate influence ND vaccine...
Purpose: This study aim to determine the role of platelet-rich plasma (PRP) exosomes as anti-inflammatory (IL-6) in a mouse model androgenetic alopecia. Methodology: There are four group alopecia mice with no treatment (control group, K1), treated PRP-exosomes (K2), 5% topical minoxidil (K3) and last combination (K4). All was evaluated clinically immunohistochemical examination IL-6 performed on 32nd day. Results: Better hair growth results were obtained compared control group. In clinical...
Infectious bursal disease is caused by infectious virus (IBDV), an immunosuppressive that targets immune cells such as B and macrophages. However, the involvement of dendritic (DCs) during IBDV infection not well understood. In this study in vitro effects live inactivated very virulent (vvIBDV) UPM0081 on bone marrow-derived DCs (BM-DC) were characterized compared with BM-DC treated lipopolysaccharide (LPS). Morphologically, LPS vvIBDV showed stellate shape when to immature BM-DC. addition,...
West Nile virus (WNV) is a zoonotic mosquito-borne flavivirus that harbored and amplified by wild birds via the enzootic transmission cycle. Wide range of hosts are found to be susceptible WNV infection including mammals, amphibians reptiles across world. Several studies have demonstrated was present in Malaysian Orang Asli captive birds. However, no data available on prevalence Malaysia. Therefore this study conducted determine serological molecular selected areas Coast Peninsular Two types...
Rattus spp. are the most common animals capable of adapting to their environment. They can be reservoirs or vectors diseases that facilitate transmission zoonotic-borne parasites humans. Hence, a study on detection in rat populations urban areas is crucial prepare for emerging zoonosis. Therefore, this aims identify blood parasites, ectoparasites, and helminths from wet markets located Klang Valley, an area with high-density human population. A total 32 rats were trapped several Malaysia....
Farmers play an integral role in minimizing disease threats and managing ongoing diseases on their farms. Various environmental factors influence the decision-making processes of farmers. Deciphering mental models farmers allows us to understand motivations reasons behind prevention control choices. This study aimed explore cattle implementing practices. Using qualitative in-depth, semi-structured interviews, seven from a university’s foster farm extension program were sampled. Interview...
The 1998 Nipah virus outbreak in Malaysia resulted major financial losses to the multi-million-dollar swine industry. While productivity and biosecurity of pig farms have improved since, some remains substandard with farmers struggling adapt current national farming policies. Farm viability animal health depends on farmers' role as decision-makers managing disease threats other aspects farm management. This study aimed describe mental model making decisions about prevention control measures...
West Nile virus is a mosquito-borne neurotropic pathogen with wide host range that constitutes significant risk to public and animal health. There limited information on WNV infection in domesticated mammals Malaysia; however, current reports indicate infections birds, macaques, bats pigs from Malaysia. In this study, 203 serum samples cattle, goats, horses were tested for the presence of anti-WNV IgG using competitive enzyme-linked immunosorbent assay (c-ELISA). Additionally, one-step...
Studies have shown that infectious bursal disease virus (IBDV) infects lymphoid cells, mainly B cells and macrophages. This study was aimed to examine the involvement of chicken splenic-derived dendritic (ch-sDCs) in specific-pathogen-free chickens following inoculation with IBDV vaccine strain (D78) a very virulent (vv) (UPM0081). Following infection, enriched activated ch-sDCs were collected by using negative selection method examined based on morphology immunophenotyping confirm isolation...
The role of wildlife such as wild birds, macaques, and bats in the spreading maintenance deadly zoonotic pathogens nature have been well documented many parts world. One pathogen is mosquitoes borne virus, namely West Nile Virus (WNV). Previous research has shown that 1:7 1:6 Malaysian birds are WNV antibody RNA positive, respectively, North America may not be susceptible to infection. This study was conducted determine status macaques found mangrove forests caves, respectively. Archive sera...
Infectious bursal disease is a highly contagious in the poultry industry and causes immunosuppression chickens. Genome-wide regulations of immune response genes inbred chickens with different genetic backgrounds, following very virulent infectious virus (vvIBDV) infection are poorly characterized. Therefore, this study aims to analyse tissue transcriptome six chicken lines 6, 7, 15, N, O P vvIBDV strain UK661 using strand-specific next-generation sequencing, by highlighting important...
Abstract Background In view of the current swine fever outbreak and government aspiration to increase goat population, a need arises control prevent outbreaks pox. Despite North Vietnam facing sporadic cases pox, this most recent had highest recorded morbidity, mortality case fatality rate. Thus, owing likelihood widespread recurrence pox infection, an analysis that was done based on selected signalment, management disease pattern (signs pathology) parameters. This includes examination...
Naïve Felidae in the wild may harbor infectious viruses of importance due to cross-species transmission between domesticated animals or human–wildlife contact. However, limited information is available on virus shedding viremia captive felids, especially Malaysia. Four cat, feline herpesvirus (FHV), calicivirus (FCV), canine distemper (CDV), and parvovirus (CPV), were screened leopards, feral cats, tigers Malaysia based isolation Crandell-Rees kidney (CRFK) cells, PCR/RT-PCR, whole-genome...
West Nile virus (WNV) is a zoonotic RNA maintained in enzootic cycles involving mosquito mainly Culex and Aedes spp. as the vector birds reservoir host.WNV endemic Africa, Europe Western Asia.Human infection results asymptomatic illness such fever, headache, tiredness, body aches, nausea, vomiting, skin rash, swollen lymph glands neuroinvasive disease are seen less than 1% of infected persons.The spectrum symptoms animals includes weakness paralysis hind limbs, impaired vision, ataxia, head...