A5021551563- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Bone health and osteoporosis research
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Bone fractures and treatments
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Elasticity and Material Modeling
- Ultrasound Imaging and Elastography
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Scoliosis diagnosis and treatment
- Orthopedic Infections and Treatments
- Titanium Alloys Microstructure and Properties
- biodegradable polymer synthesis and properties
- Additive Manufacturing and 3D Printing Technologies
- Cancer Cells and Metastasis
- Ultrasonics and Acoustic Wave Propagation
- Shoulder and Clavicle Injuries
- Dental Implant Techniques and Outcomes
- Hip disorders and treatments
- Bone Tumor Diagnosis and Treatments
University of Patras
2012-2024
Agios Andreas Hospital
1998-2001
A combined computational and experimental study of 3D-printed scaffolds made from hybrid nanocomposite materials for potential applications in bone tissue engineering is presented. Polycaprolactone (PCL) polylactic acid (PLA), enhanced with chitosan (CS) multiwalled carbon nanotubes (MWCNTs), were investigated respect their mechanical characteristics responses fluidic environments. novel scaffold geometry was designed, considering the requirements cellular proliferation properties. Specimens...
Titanium and its alloys are the most popular biomaterials replacing hard tissues in implant surgeries. Clinicians generally pleased by titanium mechanical properties non-toxicity performances; on other hand, there have been reported several cases of implantation failure, phenomenon explained sometimes as "non adherence human tissue to metallic surface." Yet, researchers that surfaces favorable for osteoblasts adhesion. Therefore, integration into body remains an unsolved problem. In present...
The hypothesis of the present research is that by altering substrate topography and/or stiffness to make it biomimetic, we can modulate cells behavior. Substrates with similar surface chemistry and varying stiffnesses topographies were prepared. Bulk PCL CNTs-reinforced composites manufactured solvent casting method electrospinning further processed obtain tunable moduli elasticity in range few MPa. To ensure same chemical profile for substrates, a protein coating was added. Substrate...
The goal of the present investigation was to find a solution crucial engineering aspects related elaboration multi-layered tissue-biomimicking composites. 3D printing technology used manufacture single-layered and gradient porous scaffolds made poly-lactic acid (PLA). manufacturing process optimized after adjusting key parameters. with 60 μm side length (square-shaped pores) showed increased stiffness values comparing other specimens. A silicone adhesive has been further join biomedical...
Computational methods were combined with an experimental setup in order to investigate the response of human umbilical cord stem cells 3D electrospun and printed scaffolds, when dynamically stimulated a bioreactor. Key parameters associated bioreactor working conditions computationally investigated using Comsol software use output for planned setup. Based on theoretical observations, influence inlet velocity, cell number, exposure time analyzed vitro adjusted accordingly. MSCs seeded...
This study was designed to assess human bone marrow cell response and particularly adhesion, proliferation, differentiation, when cultured in vitro on titanium alloy hydroxyapatite with different values of surface roughness. A further aim compare the two materials, currently used spinal surgery. Cell adhesion determined after 0.5, 2, 4, 18 hours incubation; proliferation 8, 11, 14, 16 days culture; differentiation evaluated expression alkaline phosphatase activity 8 culture. showed that...
Investigating the ability of films pristine (purified, without any functionalization) multiwalled carbon nanotubes (MWCNTs) to influence human bone marrow mesenchymal stem cells' (hBMSCs) proliferation, morphology, and differentiation into osteoblasts, we concluded following: A. MWCNTs delay proliferation hBMSCs but increase their differentiation. The enhancement markers could be a result decreased maturation extracellular matrix B. Cell spread on toward polygonal shape with many thin...
A weak scattering model was proposed for the ultrasonic frequency-dependent backscatter in dense bovine cancellous bone, using two autocorrelation functions to describe medium: one with discrete homogeneities (spherical distribution of equal spheres) and another, which considers tissue as an inhomogeneous continuum (densely populated medium). The inverse problem estimate trabecular thickness bone has been addressed. combination required closely approximate from various microarchitecture,...
A goal of current implantology research is to design devices that induce controlled, guided, and rapid healing. Nanoscale structured substrates [e.g., titania nanotubes (TNTs) or carbon (CNTs)] dramatically improve the functions conventional biomaterials. The present investigation evaluated behavior osteoblasts cells cultured on smooth nanostructured substrates, by measuring specific biomarkers [alkaline phosphatase (AP) total protein] adhesion strength followed semi-empirical modeling...
The effect of an electric field within specific intensity limits on the activity human cells has been previously investigated. However, there are a considerable number factors that influence in vitro development cell populations. In biocompatibility studies, nature substrate and its topography decisive osteoblasts bone development. Further on, electrical stimulation may activate biochemical paths contribute to faster, more effective self-adjustment proliferation types various nanosubstrates....
The onset and progression of cancer are strongly associated with the dissipation adhesion forces between cells, thus facilitating their incessant attachment detachment from extracellular matrix (ECM) to move toward metastasis. During this process, cells undergo mechanical stresses respond these membrane deformation while inducing protrusions invade surrounding tissues. Cellular response is inherently related reorganization cytoskeleton, cell-cell junctions, ECM. Moreover, role focal...
In Brief Study Design. Comparative 3-dimensional biomechanical testing. Objective. To compare 5 fixation techniques, 3 using screws or screw and plates 2 spinal, used for stabilization of complete unilateral sacroiliac dislocation in composite models. Summary Background Data. Harrington compression rods have been posterior iliosacral stabilization. Recently, the use compact spinal instrumentation has introduced joint separation to achieve immediate permanent stability, allowing early...
Abstract Mechanical loading factors at the bone‐implant interface are critical for osseointegration and clinical success of implant. The aim present investigation was to study effects mechanical strain on orthopedic biomaterial Ti‐6Al‐4V/osteoblast interface, using an in vitro model. Homogeneous applied human bone marrow derived osteoblasts (HBMDOs) cultured Ti‐6Al‐4V, physiological levels (strain magnitudes 500 microstrain (με) 1000 με, frequencies load application 0.5 Hz 1 Hz), by a...