A5106583158- Chromosomal and Genetic Variations
- Plant Disease Resistance and Genetics
- Fungal Infections and Studies
Duke University Hospital
2024
Duke Medical Center
2024
While increased mutation rates typically have negative consequences in multicellular organisms, hypermutation can be advantageous for microbes adapting to the environment. Previously, we identified two hypermutator
Abstract While increased mutation rates typically have negative consequences in multicellular organisms, hypermutation can be advantageous for microbes adapting to the environment. Previously, we identified two hypermutator Cryptococcus neoformans clinical isolates that rapidly develop drug resistance due transposition of a retrotransposon, Cnl1. Cnl1-mediated is caused by nonsense gene encoding novel RNAi component, Znf3, combined with tremendous transposon burden. To elucidate adaptative...