A5024086959- Adrenal Hormones and Disorders
- Stress Responses and Cortisol
- Hormonal Regulation and Hypertension
- Circadian rhythm and melatonin
- Hormonal and reproductive studies
- Neuroendocrine regulation and behavior
- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Lipid Membrane Structure and Behavior
- Dietary Effects on Health
- Photosynthetic Processes and Mechanisms
- Zebrafish Biomedical Research Applications
- Adrenal and Paraganglionic Tumors
- Advanced Fluorescence Microscopy Techniques
- Electrolyte and hormonal disorders
- Gene Regulatory Network Analysis
- Hypothalamic control of reproductive hormones
- Biomedical and Engineering Education
- Sleep and related disorders
- Neural Networks and Applications
- Advanced Control Systems Design
- Hemodynamic Monitoring and Therapy
- Proteins in Food Systems
- RNA Research and Splicing
- stochastic dynamics and bifurcation
University of Birmingham
2020-2025
Engineering and Physical Sciences Research Council
2017-2020
University of Exeter
2017-2020
Wellcome Trust
2017
Okinawa Institute of Science and Technology Graduate University
2014
Instituto Politécnico Nacional
2011-2012
Universidad Autónoma de Nuevo León
2004-2006
Universidad de Santiago de Chile
1998
Rhythms are intrinsic to endocrine systems, and disruption of these hormone oscillations occurs at very early stages the disease. Because adrenal hormones secreted with both circadian ultradian periods, conventional single–time point measurements provide limited information about rhythmicity and, crucially, do not during sleep, when many fluctuate from nadir peak concentrations. If blood sampling is attempted overnight, then this necessitates admission a clinical research unit, can be...
Cortisol is released upon activation of the hypothalamic–pituitary–adrenal axis, varies across day, possesses an underlying diurnal rhythm and responsive to stressors. The endogenous circadian peak cortisol occurs in morning, increases observed post-awakening have been named awakening response (CAR) based on belief that act waking up stimulates secretion. However, objective evidence induces secretion limited. We used a mixed effects model with linear spline fitted data examine tissue-free...
Significance Our ability to respond stress depends on a remarkably dynamic process of hormone secretion. The rapid release glucocorticoid hormones from the adrenal glands is critical mount such an efficient response stress, particularly during inflammation. Although many key factors involved in this have been studied, way which these interact dynamically with one another regulate secretion has not investigated. Here, we develop mathematical model regulatory network controlling synthesis and,...
Chronotherapy is a pharmaceutical intervention that considers the patient's internal circadian time to adjust dosing time. Although it can dramatically improve drug efficacy and reduce toxicity, large variability in across within individuals has prevented chronotherapies from progressing beyond clinical trials. To translate chronotherapy developments into real-world outpatient scenario, personalized characterization analysis of essential. Here, we describe recent advances wearable technology...
Neuroendocrine axes display a remarkable diversity of dynamic signalling processes relaying information between the brain, endocrine glands, and peripheral target tissues. These include oscillations, elastic responses to perturbations, plastic long term changes observed from cellular systems level. While small transient can be considered physiological, larger longer disruptions are common in pathological scenarios involving more than one neuroendocrine axes, suggesting that robust control...
Major surgery and critical illness produce a potentially life-threatening systemic inflammatory response. The hypothalamic–pituitary–adrenal (HPA) axis is one of the key physiological systems that counterbalances this inflammation through changes in adrenocorticotrophic hormone (ACTH) cortisol. These hormones normally exhibit highly correlated ultradian pulsatility with an amplitude modulated by circadian processes. However, these dynamics are disrupted major illness. In work, we...
<title>Abstract</title> Primary aldosteronism (PA) affects 5–20% of the hypertensive population and is associated with increased cardiovascular metabolic risks compared primary hypertension. PA significantly underdiagnosed partly due to our inability capture pulsatile variability aldosterone over 24 hours in clinical settings. To gain insight into steroid secretion patterns we applied multiplex 24-hour profiling free corticosteroids concentrations subcutaneous tissue microdialysate 60...
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Stochastic models of reaction networks are widely used to depict gene expression dynamics. However, stochastic does not necessarily imply accurate, as subtle assumptions can yield erroneous results, masking key discrete effects. For instance, transcription and translation instantaneous processes-explicit delays separate their initiation from the appearance functional products. often ignored in stochastic, single-gene models. By consequence, effects such delay-induced oscillations at...
The impact of stress on reproductive function is significant. Hypothalamic paraventricular nucleus (PVN) corticotrophin-releasing hormone (CRH) plays a major role in regulating the response. Understanding how hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-gonadal (HPG) interact crucial for comprehending can lead to dysfunction. However, whether influences via modulating PVN CRH or HPA sequelae not fully elucidated.
Abstract A systems level coordination of physiological rhythms is essential to sustain healthy states, especially in the face stimuli that may disrupt such rhythms. The timing meals, medication and chronic stress can profoundly influence metabolism, which depends on dynamic interactions between glucose, insulin cortisol. Although metabolic endocrine axes are simultaneously disrupted many diseases, a theoretical framework understand how chronodisruption leads disease lacking. By developing...
Diffusion barriers are effective means for constraining protein lateral exchange in cellular membranes. In Saccharomyces cerevisiae, they have been shown to sustain parental identity through asymmetric segregation of ageing factors during closed mitosis. Even though extensively studied the plasma membrane, their and organization within nucleus remains poorly understood. Based on different lines experimental evidence, we present a model composition structural nuclear diffusion barrier...
In the context of glucocorticoid (GC) therapeutics, recent studies have utilised a subcutaneous hydrocortisone (HC) infusion pump programmed to deliver multiple HC pulses throughout day, with purpose restoring normal circadian and ultradian GC rhythmicity. A key challenge for advancement novel replacement therapies is calibration pumps against cortisol levels measured in blood. However, repeated blood sampling sessions are enormously labour-intensive both examiners examinees. These also...
The time course of the hydrolytic action porcine pancreatic phospholipase A 2 on sonicated dimyristoylphosphatidylcholine liposomes in presence variable NaCl concentrations has been studied at temperatures between 17 and 36 °C; these are gel phase. At a concentration 10 mM, hydrolysis shows small constant lag period 6–8 min all within this range. As temperature is raised into liquid crystalline range, latency phase lengthens monotonically so that °C it reaches 55 min. An increase to 1 M...
Unveiling the mechanisms through which somitogenesis regulatory network exerts spatiotemporal control of somitic patterning has required a combination experimental and mathematical modeling strategies. Significant progress been made for zebrafish clockwork. However, due to its complexity, clockwork amniote segmentation not fully elucidated. Here, we address question how oscillations are arrested in clock. We do this by constructing minimal model network, privileges architectural information...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
ABSTRACT Neuroendocrine axes display a remarkable diversity of dynamic signalling processes relaying information between the brain, endocrine glands, and peripheral target tissues. These include oscillations, elastic responses to perturbations, plastic long term changes observed from cellular systems level. While small transient can be considered physiological, larger longer disruptions are common in pathological scenarios involving more than one neuroendocrine axes, suggesting that robust...