A5042930029- Tryptophan and brain disorders
- Metabolism and Genetic Disorders
- Aluminum toxicity and tolerance in plants and animals
- Mycotoxins in Agriculture and Food
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Stress Responses and Cortisol
- Folate and B Vitamins Research
- Neurological and metabolic disorders
- Alzheimer's disease research and treatments
- Neonatal Health and Biochemistry
- Wheat and Barley Genetics and Pathology
- Synthesis and biological activity
- Circadian rhythm and melatonin
- Bee Products Chemical Analysis
- Oral microbiology and periodontitis research
- Diabetes and associated disorders
- Pharmacological Effects and Toxicity Studies
- Hydrogen's biological and therapeutic effects
- Alcohol Consumption and Health Effects
- Adrenal Hormones and Disorders
- Psoriasis: Treatment and Pathogenesis
- Silymarin and Mushroom Poisoning
- Complementary and Alternative Medicine Studies
- Sulfur Compounds in Biology
Hacettepe University
2016-2025
Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi
2017
Innsbruck Medical University
2014
Walter de Gruyter (Germany)
2014
Abstract BACKGROUND The present study aimed to investigate the occurrence of multiple toxic fungal and bacterial metabolites in 156 animal feed ( n = 77) maize 79) samples collected from three regions Upper Egypt. target analytes were quantified using ‘dilute shoot’ approach, followed by a liquid chromatography tandem mass spectrometry analysis. RESULTS In total, 115 detected both matrices, including regulated mycotoxins European Union, addition modified forms such as...
This survey was conducted to investigate the contamination by multiple mycotoxins, aflatoxins (AFB1, AFB2, AFG1, and AFG2), ochratoxin A (OTA), zearalenone (ZEA) in 61 samples of maize 17 commercial animal feed samples, aflatoxin M1 (AFM1) raw dairy milk (n = 20) collected from Assiut City Upper Egypt. Multi-mycotoxin immunoaffinity columns were used for cleanup mycotoxin purification. An HPLC–FLD system with an on-line post-column photochemical derivatization detection target toxins. AFB1...
This study aimed to evaluate the possible changes of neopterin, biopterin levels and tryptophan degradation in diabetes compare results within groups with healthy subjects. Diabetes mellitus patients controls were recruited study. Patients further subgrouped according their drug therapy. Serum neopterin concentrations detected by ELISA. Urinary biopterin, serum (Trp) kynurenine (Kyn) HPLC. There was no difference between urinary (p > 0.05, all). Trp Kyn significantly different type 1 (T1DM)...
There has been a significant concern regarding the potential health risks for humans and animals via foods feeds that are contaminated with different agents. Particularly, mycotoxin contamination is of great importance as it widespread unpreventable. In both feeds, molds produce secondary metabolites called mycotoxins; these produced generally after fungi reach their maturity. Depending on definition used, hundreds fungal compounds recognized mycotoxins. However, attention mainly focused...
Although Th2 immune activation is predominant in allergic diseases, neopterinlevels and indoleamine 2,3-dioxygenase (IDO)-1 activity (kynurenine:tryptophan ratio), which reflect Th1 activity, increase with interferon-gamma (IFN-γ) stimulation. We investigated neopterin, tryptophan, kynurenine levels as biomarkersof the system changes IDO-1 activityin children asthma, rhinitis, atopic dermatitis, well relationship between these biomarkers total IgE level, age, disease severity.We divided 205...
Alzheimer's disease (AD) is a neurodegenerative disorder that causes memory loss and dementia characterized by decline in cognitive functions. Brain infections, especially induced herpes simplex virus type-1 (HSV-1), are suggested to play key role the pathogenesis of AD. Within scope this study, two different AD models (Tau model amyloid beta [Aβ]) were created SH-SY5Y cell line, HSV glycoprotein B (gB) was applied line on generated models. Study groups (n = 3) designed as (1) control, (2)...
Cancer treatment regimens often combine chemotherapeutics, supportive therapies, and medications for comorbidities, increasing the risk of drug-drug (DDIs) drug-food interactions (DFIs). These can alter pharmacokinetics pharmacodynamics anticancer agents, potentially leading to failure, severe adverse events, or hospitalization. Elderly patients, polypharmacy, narrow therapeutic index many chemotherapeutics further compound these challenges. This review explores mechanisms underlying DDIs...
Objectives: The aim was to simultaneously investigate inflammatory biomarkers, neopterin, the kynurenine/tryptophan (Kyn/Trp) pathway, vitamin D (VitD), binding protein (VDBP), and erythrocyte folate, in cerebral palsy (CP). Methods: A case–control study conducted at Mersin University Hospital. Three- ten-year-old patients with spastic CP (n = 50) age- gender-matched healthy controls 55) were included. Serum levels of Trp, Kyn 25OHD, plasma VDBP, folate concentrations measured....
Indoleamine 2,3-dioxygenase (IDO), which degrades tryptophan (Trp) to kynurenine (Kyn), has been demonstrated contribute modulation of allergic responses. However, the role IDO in food allergy not yet elucidated.Serum Trp and Kyn concentrations were analyzed by high-pressure liquid chromatography. Expression gene was measured real-time PCR. The levels interleukin (IL)-4, IL-10, interferon (IFN)-γ cell culture supernatants ELISA.Kyn/Trp (IDO activity) significantly lower subjects with (n =...
Abstract Dihydrolipoic acid (DHLA) is a natural antioxidant known for its ability to counteract metal toxicity and oxidative stress. It has shown the potential safeguard cells from harmful environmental substances. may hold therapeutic benefits in treating neurodegenerative disorders by defending against damage chronic inflammation. Thus, this study aimed explore neuroprotective effects of DHLA aluminum (Al)‐induced using an Alzheimer's disease (AD) model vitro. The focused on two important...
Nitrites are ubiquitous environmental contaminants present in drinking water and foods. Nitrosamines can be formed endogenously from nitrate nitrite secondary amines or may food, tobacco smoke, water. The major goal of this work was to evaluate the cytotoxic, reactive oxygen species (ROS)-producing genotoxic effects nitrosamines possible protection by ascorbic acid HepG2 cells. It found that nitrite, N-nitrosodimethylamine (NDMA), N-nitrosodiethylamine (NDEA), N-nitrosomorpholine (NMOR)...
Abstract Workers in denim sandblasting are at a high risk of developing silicosis, an occupational lung disease caused by inhaling crystalline silica dust. The development and progress silicosis is associated with the activation immune system oxidative stress. In former, interferon-gamma induces both neopterin release enzyme indoleamine [2, 3]-dioxygenase (IDO) various cells. determination kynurenine-to-tryptophan ratio concentration has proven to be efficient method monitor status IDO...