A5103237637- Chemical Synthesis and Analysis
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Advanced Proteomics Techniques and Applications
- Antimicrobial Peptides and Activities
- Monoclonal and Polyclonal Antibodies Research
- HIV/AIDS drug development and treatment
- DNA Repair Mechanisms
- Chemical synthesis and alkaloids
- Immunotherapy and Immune Responses
- Synthetic Organic Chemistry Methods
- Photosynthetic Processes and Mechanisms
- Protein purification and stability
- Per- and polyfluoroalkyl substances research
- Fluorine in Organic Chemistry
- Toxin Mechanisms and Immunotoxins
- Cancer Treatment and Pharmacology
- Microtubule and mitosis dynamics
ETH Zurich
2019
National Institute of Infectious Diseases
2015-2018
Scynexis (United States)
2015-2016
Tokyo University of Science
2012
Kobe Gakuin University
2012
The sodium taurocholate co-transporting polypeptide (NTCP) is the main target of most hepatitis B virus (HBV) specific entry inhibitors. Unfortunately, these agents also block NTCP transport bile acids into hepatocytes, and thus have potential to cause adverse effects. We aimed identify small molecules that inhibit HBV while maintaining transporter function.
ABSTRACT Anti-hepatitis B virus (HBV) drugs are currently limited to nucleos(t)ide analogs (NAs) and interferons. A challenge of drug development is the identification small molecules that suppress HBV infection from new chemical sources. Here, a fungus-derived secondary metabolite library, we identify structurally novel tricyclic polyketide, named vanitaracin A, which specifically inhibits infection. Vanitaracin inhibited viral entry process with submicromolar 50% inhibitory concentration...
In analogy to biosynthetic pathways leading bioactive natural products, synthetic fermentation generates mixtures of molecules from simple building blocks under aqueous, biocompatible conditions, allowing the resulting cultures be directly screened for biological activity. this work, a novel β-peptide antibiotic was successfully identified using platform. Phenotypic screening carried out in an initially random fashion, identification active cultures. Subsequent deconvolution, focused...
The total synthesis of (+)-Sch 725680, a member the hydrogenated azaphilone family, has been accomplished. confirmed absolute configuration and biological activities natural product. A key reaction to construct core skeleton is Ti-mediated aldol reaction.
MA026, a novel lipocyclodepsipeptide, exhibits multiple antiviral activity, and its mode of action is unrevealed. MA026 has the potential to create drug thus more biological characterizations are required. To accomplish investigation, flexible chemical synthesis essential. consists (R)-3-hydroxydecanoic acid, linear peptide cyclodepsipeptide. maximize convergency, was devided into three segments: branched cyclodepsipeptide 2, tripeptide 3 fatty acid moiety 4. Macrocyclization depsipeptide...
In analogy to biosynthetic pathways leading bioactive natural products, synthetic fermentation generates mixtures of molecules from simple building blocks under aqueous, biocompatible conditions, allowing for the resulting cultures be directly screened biological activity. this work, a novel beta-peptide antibiotic was successfully identified using platform. Phenotypic screening carried out in an initially random fashion, identification active cultures. Subsequent deconvolution, focused and...
In analogy to biosynthetic pathways leading bioactive natural products, synthetic fermentation generates mixtures of molecules from simple building blocks under aqueous, biocompatible conditions, allowing for the resulting cultures be directly screened biological activity. this work, a novel beta-peptide antibiotic was successfully identified using platform. Phenotypic screening carried out in an initially random fashion, identification active cultures. Subsequent deconvolution, focused and...