A5035479767- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Ocular Diseases and Behçet’s Syndrome
- Retinopathy of Prematurity Studies
- Ophthalmology and Eye Disorders
- Cardiovascular Function and Risk Factors
- Ocular Infections and Treatments
- Ocular Surface and Contact Lens
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Anesthesia and Sedative Agents
- Gastrointestinal disorders and treatments
- Bone and Joint Diseases
- Cardiac Imaging and Diagnostics
- Medical Imaging and Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Traditional Chinese Medicine Analysis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Esophageal and GI Pathology
- Linguistic, Cultural, and Literary Studies
- Clusterin in disease pathology
Chinese University of Hong Kong
2018-2024
Hong Kong Eye Hospital
2014-2024
Case Western Reserve University
2024
University School
2024
Hamilton Health Sciences
2019
Grantham Hospital
2018
Hospital Authority
2015
Queen Mary Hospital
2013-2015
Queen Mary University of London
2014
Austin Health
2010-2011
BackgroundSpectral-domain optical coherence tomography (SDOCT) can be used to detect glaucomatous optic neuropathy, but human expertise in interpretation of SDOCT is limited. We aimed develop and validate a three-dimensional (3D) deep-learning system using volumes neuropathy.MethodsWe retrospectively collected dataset including 4877 disc cube for training (60%), testing (20%), primary validation (20%) from electronic medical research records at the Chinese University Hong Kong Eye Centre...
To identify the optimal energy level to be used in selective laser trabeculoplasty (SLT) for maximal intraocular pressure (IOP) reduction open-angle glaucoma (OAG) patients.This cohort sequentially recruited OAG subjects Hong Kong, China during 2011 2012. All received a single session of SLT with near confluent spots 360 degrees trabecular meshwork. An initial 0.8 mJ was titrated until bubble formation just visible. The main outcomes included: change IOP (pre-SLT 1 mo post-SLT) and total...
A randomized control trial to evaluate the effect of adjuvant selective laser trabeculoplasty versus medication alone in primary open-angle glaucoma: preliminary results Jacky WY Lee,1,2 Catherine WS Chan,2 Mandy OM Wong,3 Jonathan CH Chan,3 Qing Li,2 Jimmy SM Lai2 1The Department Ophthalmology, Caritas Medical Centre, 2The The University Hong Kong, 3The Queen Mary Hospital, Kong Background: objective this study was investigate effects (SLT) on intraocular pressure (IOP) control, use,...
Abstract Microcirculatory insufficiency has been hypothesized in glaucoma pathogenesis. There is a scarcity of data to comprehensively examine the changes retinal microvasculature and its role normal tension (NTG). We conducted cross-sectional case–control study included 168 eyes from 100 NTG patients 68 healthy subjects. Quantitative arteriolar venular metrics were measured photographs using computer-assisted program. Radial peripapillary capillary network was imaged with OCT-A quantitative...
We aim to develop a multi-task three-dimensional (3D) deep learning (DL) model detect glaucomatous optic neuropathy (GON) and myopic features (MF) simultaneously from spectral-domain optical coherence tomography (SDOCT) volumetric scans.Each scan was labelled as GON according the criteria of retinal nerve fibre layer (RNFL) thinning, with structural defect that correlated in position visual field (i.e., reference standard). MF were graded by SDOCT en face images, defined presence...
Deep learning (DL) is promising to detect glaucoma. However, patients' privacy and data security are major concerns when pooling all for model development. We developed a privacy-preserving DL using the federated (FL) paradigm glaucoma from optical coherence tomography (OCT) images.
To investigate the correlation of intraocular pressure (IOP)-lowering effects selective laser trabeculoplasty (SLT) between 2 eyes treated with SLT in open-angle glaucoma (OAG).This prospective cohort study sequentially recruited subjects bilateral OAG. All received a single session 360-degree treatment. Success was defined as IOP reduction ≥20%. Spearman used to compare following parameters SLT: at day 1, 1 week, and month; percentage success; reduction.In 84 42 that treatment, both had...
Abstract Purpose To investigate the features of small‐to‐medium (choriocapillaris and Sattler’s layer) large (Haller’s sized vessel layers macular choroid in normal‐tension glaucoma (NTG) patients using swept‐source optical coherence tomography (SS‐OCT). Methods We conducted an observational cross‐sectional study 234 NTG eyes from 134 patients, 203 normal 109 non‐glaucomatous control subjects. used Image J to segment choroidal layer then a Python script measure average thickness (MCT)...
To prospectively determine the relationship between optical coherence tomography angiography (OCTA) metrics and visual field (VF) progression in eyes with normal tension glaucoma (NTG).Prospective, cohort study conducted from January 2017 to October 2021. OCTA at peripapillary region (circumpapillary vessel density (cpVD), diameter index (VDI) fractal dimension (FD) radial superficial capillary network), macular (macular density, foveal avascular zone (FAZ) area, FAZ circularity FD plexus...
To determine the demographic, ocular, and systemic factors associated with long-term intraocular pressure (IOP) fluctuation in primary angle closure disease (PACD).This prospective cohort study included 422 PACD eyes from 269 Chinese patients, including 274 glaucoma (PACG) 152 closure/primary suspect (PAC/PACS) eyes. Long-term IOP defined as SD of all measurements over 2 years (at least 5 total). patients were recruited followed up 3 monthly. Eyes IOP-lowering surgery or lens extraction...
To compare the intraocular pressure (IOP) lowering effect and safety profile between pattern scanning laser trabeculoplasty (PSLT) selective (SLT) in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT) over a 12-month follow-up.132 POAG OHT were consecutively enrolled randomised (1:1) to receive PSLT (n=65) SLT (n=67) single centre. IOP was measured before then on 1 day, week, 1, 3, 6, 9 12 months after PSLT/SLT. The outcome measure proportion of ≥20% reduction at...
Aim To compare the vertical cup to disc ratio (VCDR) measurements obtained with optical coherence tomography (OCT), Heidelberg retina (HRT) and stereophotography of optic nerve head (ONH) in patients ocular hypertension (OHT), their corresponding estimated 5-year risk for development glaucoma. Methods ONH images OHT were taken by fundus camera (stereoscopic images), OCT HRT. Optic stereophotographs evaluated a stereo-viewer two glaucoma specialists (SP1 SP2) VCDR was measured ImageJ...
While cytomegalovirus (CMV) anterior uveitis (AU) patients often require glaucoma surgery, the effectiveness of systemic anti-viral in long-term intraocular pressure (IOP) control is not well established. Our study aims to identify 2-year efficacy and safety oral valganciclovir CMV AU with uncontrolled IOP.In this retrospective case series, one eye from each 17 immunocompetent PCR-proven who received a single course for 20-148 days medically IOP during 2008-2018 were identified. They...
This case report illustrates the use of ExPRESS mini-shunt in a pediatric glaucoma patient. We describe management steroid-induced with 9-year-old boy allergic keratoconjunctivitis. The intraocular pressure both his eyes was uncontrolled medical and laser treatment. Both were treated mitomycin-C. Transient overfiltration postoperative hypotony occurred resolved after 2 weeks. One year postoperatively, maintained below 21 mm Hg without medication 1 eye. Bleb needling mitomycin-C done to...