A5026603049- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Ophthalmology and Eye Disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- IgG4-Related and Inflammatory Diseases
- Retinopathy of Prematurity Studies
- Retinal Imaging and Analysis
- Ophthalmology and Visual Impairment Studies
- Neonatal Respiratory Health Research
- Neuroendocrine Tumor Research Advances
- Ocular Surface and Contact Lens
- Retinal and Macular Surgery
- Corneal Surgery and Treatments
- Pituitary Gland Disorders and Treatments
- Preterm Birth and Chorioamnionitis
- Retinal and Optic Conditions
- Soft tissue tumor case studies
- Nasolacrimal Duct Obstruction Treatments
- Cerebral Venous Sinus Thrombosis
- Neonatal Health and Biochemistry
- Neonatal and fetal brain pathology
- Ocular Diseases and Behçet’s Syndrome
- Ocular Infections and Treatments
- Histiocytic Disorders and Treatments
Prince of Wales Hospital
2016-2025
Chinese University of Hong Kong
2008-2025
Hong Kong Eye Hospital
2003-2025
Alice Ho Miu Ling Nethersole Hospital
2021-2024
Weatherford College
2023
Hospital Authority
2003-2021
<h3>Importance</h3> Early onset of myopia is associated with high later in life, and irreversible once developed. <h3>Objective</h3> To evaluate the efficacy low-concentration atropine eyedrops at 0.05% 0.01% concentration for delaying myopia. <h3>Design, Setting, Participants</h3> This randomized, placebo-controlled, double-masked trial conducted Chinese University Hong Kong Eye Centre enrolled 474 nonmyopic children aged 4 through 9 years cycloplegic spherical equivalent between +1.00 D to...
Background To report the presenting clinical, serological and treatment profiles of 1439 patients with thyroid eye disease (TED) from a tertiary centre in Hong Kong. Study populations Consecutive TED presented to Thyroid Eye Clinic (TEC), Chinese University Kong between 2014 2023. Methods Prospective cohort masked review medical records orbital images. Results A total (70% female, 98% Han Chinese) (26% ex/current smoker), at 43±5.9 years old, were reviewed. The first symptoms TEC evaluation...
Diabetic macular edema (DME) is the primary cause of vision loss among individuals with diabetes mellitus (DM). We developed, validated, and tested a deep learning (DL) system for classifying DME using images from three common commercially available optical coherence tomography (OCT) devices.We trained validated two versions multitask convolution neural network (CNN) to classify (center-involved [CI-DME], non-CI-DME, or absence DME) three-dimensional (3D) volume scans 2D B-scans,...
The study aims to determine the prevalence of strabismus and its risk factors among school children in Hong Kong. This is a cross-sectional involving 6-8 year old from different districts 4273 received comprehensive ophthalmological examination, cycloplegic auto-refraction, best corrected visual acuity (BCVA), anterior segment cover/uncover test, ocular motility, fundus examination. Demographic information, pre- post- natal background, parental smoking status, family history were obtained...
To evaluate the cost-effectiveness of phacoemulsification simulation training in virtual reality simulator and wet laboratory on operating theater performance.Residents were randomized to a combination or phacoemulsification. A reference control group consisted trainees who had without All assessed performance 3 sequential cataract patients. International Council Ophthalmology Surgical Competency Assessment Rubric-phacoemulsification (ICO OSCAR phaco) scores by 2 masked independent graders...
Aims To investigate the associations of genetic variants previously linked to axial length (AL) and spherical equivalent refraction (SE) in adults with refractive error related endophenotypes children, at baseline 3-year follow-up. Methods 15 candidate single-nucleotide polymorphisms (SNPs), selected from previous Genome-Wide Association Studies meta-analyses, were genotyped 2819 Chinese who had undergone follow-up cycloplegic refraction, ocular biometry health examinations. Linear...
To report an explainable deep learning (XDL) system to automatically detect thyroid eye disease (TED) using facial images. Prospective study develop and evaluate a deep-learning diagnostic algorithm METHODS: A dataset consisting of 302 289 images newly diagnosed, treatment-naïve, TED patients healthy subjects was compiled, annotated applied train the XDL model. It consisted periocular landmarks localization network that identified on images, diagnosis (TDN) uses binary classification The...
We aim to develop a multi-task three-dimensional (3D) deep learning (DL) model detect glaucomatous optic neuropathy (GON) and myopic features (MF) simultaneously from spectral-domain optical coherence tomography (SDOCT) volumetric scans.Each scan was labelled as GON according the criteria of retinal nerve fibre layer (RNFL) thinning, with structural defect that correlated in position visual field (i.e., reference standard). MF were graded by SDOCT en face images, defined presence...
Deep learning (DL) is promising to detect glaucoma. However, patients' privacy and data security are major concerns when pooling all for model development. We developed a privacy-preserving DL using the federated (FL) paradigm glaucoma from optical coherence tomography (OCT) images.
BackgroundDiabetic macular edema (DME) is the primary cause of irreversible vision loss among people with diabetes and can be accurately detected by using optical coherence tomography (OCT). We developed validated a deep learning (DL) model to classify DME on OCT volumetric scans, enhanced federated advanced DL methods safeguard patient privacy improve generalizability in analyzing unseen scans. The performance effectiveness were then prospectively evaluated real-world diabetic retinopathy...
Objective To investigate the associations of multiple single-nucleotide polymorphisms (SNPs) with severities and endophenotypes myopia in children. Methods A total 3300 children aged 5–10 years were recruited: 137 moderate high (SE≤−3.0D), 670 mild (−3.0D<SE≤−0.5D) 2493 controls (SE>−0.5D). 13 SNPs genes/loci selected for genotyping all subjects using TaqMan assays. Associations between each SNP ocular traits (spherical equivalent (SE), axial length (AL) corneal radius (CR)) analysed....
Oral corticosteroid remains the first-line treatment of IgG4-related ophthalmic disease, but steroid-dependence is common and serious. Factors associated with steroid dependence relapse have to be further explored.A city-wide, biopsy-proven, Chinese cohort.Retrospective, masked review medical records, orbital images histopathology reports.There were 101 patients at least 24-month follow-up. Up 82% (82/101) received oral as treatments, 7 them also concomitant steroid-sparing agents...
To document the epidemiology, presentation, clinical interventions, and outcomes of paediatric glaucoma in Hong Kong.Methods: This multicentre territory-wide retrospective study was performed by reviewing charts patients with six clusters Kong Hospital Authority The Chinese University from 2006 to 2015.Results: included 150 eyes 98 (presenting age: 5.2±5.7 years).Of them, 35 (23.3%) had primary congenital glaucoma, 22 (14.7%) juvenile open-angle 93 (62.0%) secondary glaucoma.The most...
To describe a case of incontinentia pigmenti with proliferative retinopathy successfully treated by combination repeated retinal laser photocoagulation and intravitreal ranibizumab injection.Single interventional report 4-year-old girl, known incontientia pigmenti, first screened at the age two, presented retinopathy. Sole treatment panretinal failed to control progression neovascularization. Intravitreal injections were used as an adjunct therapy.The was brought under halted till this date...
Purpose Clinical phenotypes in Immunoglobulin G4-related disease (IgG4-RD) according to the patterns of affecting organs have different risks malignancies. We attempt determine association malignancies with IgG4-related ophthalmic (IgG4-ROD). Design Retrospective cohort study. Methods Review medical records, orbital images and histopathology reports a territory-wide biopsy proven IgG4-ROD patients from 2005–2019. Findings Among 122 who had biopsies taken adnexal lesions including lacrimal...
Purpose: To evaluate the presenting radiological features of immunoglobulin G4–related ophthalmic disease (IgG4-ROD) and their associations with IgG4-related optic neuropathy (IgG4-RON), ocular adnexal lymphoma (IgG4-ROL). Methods: A territory-wide, biopsy-proven, Chinese cohort. Masked review orbital images, medical records, histopathology reports. Results: total 115 (94%) 122 patients in our cohort had preoperative images (computed tomography=105, magnetic resonance imaging=40). Among...