A5100553501- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Cervical and Thoracic Myelopathy
- Medical Imaging and Analysis
- Bone Metabolism and Diseases
- Bone Tissue Engineering Materials
- Heterotopic Ossification and Related Conditions
- Mesenchymal stem cell research
- Musculoskeletal pain and rehabilitation
- Bone health and treatments
- Cancer, Lipids, and Metabolism
- TGF-β signaling in diseases
- Infectious Diseases and Tuberculosis
- Anesthesia and Pain Management
- Periodontal Regeneration and Treatments
- Pelvic and Acetabular Injuries
- Orthopaedic implants and arthroplasty
- Toxin Mechanisms and Immunotoxins
- Developmental Biology and Gene Regulation
- Connective tissue disorders research
- Orthopedic Infections and Treatments
- Tendon Structure and Treatment
- Nerve Injury and Rehabilitation
- Connective Tissue Growth Factor Research
Peking University
2015-2025
Peking University Third Hospital
2015-2025
Ministry of Education of the People's Republic of China
2022-2024
Peking University International Hospital
2020
Massachusetts General Hospital
2014
Retrospective review.To perform a single-institution analysis of incidence, treatment, and clinical outcome in patients with thoracic ossification the ligamentum flavum (OLF) who experienced dural tears cerebrospinal fluid (CSF) leakage.There is paucity reports focusing on CSF leakage after OLF surgery. Because adhesion are common features OLF, incidence high represents significant challenge.A total 266 were admitted to our hospital from 1995 2011. Each patient's medical records reviewed...
This was a retrospective review.The aim of this study to examine the epidemiological characteristics and causes spinal cord compression in thoracic stenosis (TSS).As canal is relatively narrow has poor blood supply, severe neurological symptoms may develop if TSS not treated promptly. However, as it rare, less often studied its clinical features are recognized.Between 2005 2012, 427 patients diagnosed with underwent surgery our department. The male female ratio 1.4:1. mean age 53 years. most...
In Brief Study Design. A case–control association study was conducted to investigate the genetic etiology for ossification of ligamentum flavum (OLF) and posterior longitudinal ligament spine (OPLL). Objective. To determine whether COL6A1 polymorphisms are associated with susceptibility OLF OPLL in Chinese Han population. Summary Background Data. The has been identified as a gene Japanese. may be different among various populations, so we investigated also similar epidemiology, etiology,...
Abstract Background To analyze the effect of different types bone cement distribution after percutaneous vertebroplasty (PVP) in patients with osteoporotic vertebral compression fracture (OVCF). Methods One hundred thirty seven single level OVCF who underwent PVP were retrospectively analyzed. The divided into two groups according to distribution. Group A: contacted both upper and lower endplates; B: missed at least one endplate. B was 3 subgroups. B1: only B2: B3: located middle body....
Abstract Ossification of the ligamentum flavum (OLF) is a pathology almost only reported in East Asian countries. The leading cause OLF thoracic spinal canal stenosis and myelopathy. In this study, role miR‐199b‐5p jagged 1 (JAG1) primary cell osteogenesis was examined. MiR‐199b‐5p found to be down‐regulated during osteogenic differentiation cells, while overexpression inhibited differentiation. addition, JAG1 up‐regulated knockdown via RNA interference caused an inhibition Notch signalling...
Autologous bone marrow mesenchymal stem cell (BMSC)–calcium phosphate ceramic composites were constructed in vitro and implanted as a graft substitute for lumbar anterior interbody fusion rhesus monkeys to determine the osteogenic capacity of composites. Nine adult underwent L3–L4 L5–L6 diskectomy via an retroperitoneal approach. Two sites each animal randomly assigned two three treatments: autogenous tricortical iliac crest (autograft group), cell-free (ceramic or BMSC–ceramic composite...
Mechanical stress is considered to be an important factor in the progression of thoracic ossification ligament flavum (TOLF). To elucidate mechanism underlying mechanical stress-induced TOLF, we investigated effect stretching on cultured cells derived from TOLF and non-TOLF patients. We found that mRNA expression alkaline phosphatase (ALP), osteocalcin, Runx2, osterix, but not Dlx5 Msx2, was significantly increased by cells. In addition, seems finely tuned stretching-triggered activation...
Object The object of this study was to compare the clinical and radiographic outcomes 36 patients with posttuberculosis kyphosis who underwent one two types osteotomy. Methods Each patient single-stage correction via a posterior surgical approach. A modified pedicle subtraction osteotomy (mPSO) performed when kyphotic deformity less than 70° (7 cases), whereas vertebral column resection (VCR) exceeded (29 cases). Full-length standing radiographs were obtained before surgery at follow-up...
ABSTRACT Objective High‐grade dysplastic spondylolisthesis (HGDS) is a relatively rare condition mainly involving the L5/S1 segment of spine and occurring in children adolescents. Whether surgical fixation should be L5–S1 monosegmental or extended up to L4 remains controversial. This study aimed compare clinical outcomes risk adjacent between L4–S1 double‐segmental for pediatric HGDS. Methods retrospective control Pediatric patients diagnosed with HGDS March 2007 October 2022 at our hospital...
ABSTRACT Purpose There are many causes of thoracic ossification the ligamentum flavum (TOLF), which mechanical stress factors have gained increasing attention. This study aimed to explore potential pathogenesis TOLF by comparing spinal sagittal alignment parameters between patients with and an asymptomatic population. Methods We retrospectively included who underwent surgical treatment for myelopathy caused OLF at Peking University Third Hospital from 2012 2022. Sagittal measured picture...
Lumbar disk herniation in adults is thought to be caused by repetitive overloading and age-rated degenerative changes. However, these causes are absent children adolescent patients. We assume that structural malformations the lumbar spine could predispose intervertebral disks early degeneration hence need surgically fused. This issue has never been raised before.To investigate assumption fused.Lumbar configurations, including height of intercrestal line, length L5 transverse processes,...
Abstract Background Pedicle screw and lamina hook (PSLH) technique is an effective popular method for direct pars repair of lumbar spondylolysis. There a lack studies to explore factors that may influence the healing spondylolysis after surgery. The present study aimed investigate associated with non-fusion PSLH technique. Methods A total 55 subjects (average age 21.1 ± 6.3 years, 120 defects) diagnosed symptomatic underwent surgery were followed up their clinical data analyzed. Subjects...
Patients undergoing lumbar spinal surgery may experience considerable pain in the early postoperative period, and poor control after multilevel fusion is frequently associated with multiple complications delayed discharge from hospital.The current study evaluated efficacy safety of preemptive analgesia intrathecal morphine (ITM) patients posterior surgery.Double-blinded, randomized, controlled trial.Ninety-two aged between 18 80 years who were scheduled to undergo elective laminectomy...
Abstract Background Thoracic spinal stenosis (TSS) is a rare but intractable disease that fails to respond conservative treatment. decompression, which traditionally performed using high-speed drills and Kerrison rongeurs, time-consuming technically challenging task. Unfavorable outcomes high incidence of complications are the major concerns. The development adaptation ultrasonic bone scalpel (UBS) have promoted its application in various operations, standard operating procedure thoracic...
Objectives: To analyze the clinical characteristics and surgical results of posttraumatic kyphosis thoracolumbar segment. Methods: Thirty-four patients with segment underwent posterior osteotomy, correction, fixation at our hospital. The apex was from T10 to L2. There were 15 male 19 female patients. mean age 48.9 years. Full-spine standing radiographs obtained before surgery, after follow-up. sagittal spine balance status evaluated, kyphotic angle, lumbar lordotic thoracic angle measured....
in this paper, the authors' goal was to evaluate feasibility, safety, and efficacy of apical segment resection osteotomy with dual axial rotation correction for severe focal kyphosis by examining outcomes.between May 2004 December 2006, authors treated 23 patients (average Cobb angle 86.9°, range 50°-130°) using segmental instrumented anterior column reconstruction fusion. Radiographic assessment sagittal plane balance kyphotic (including a scoliosis 9 cases) performed each patient before...
There have been several surgical approaches used in the treatment of thoracolumbar disc herniation (TLDH) from T10/11 to L1/2. However, central calcified TLDH cases are still challenging spine surgeons. The anterior transthoracic and lateral/posterolateral all essentially performed one side; thus, compressive lesion dura matter on other side spinal canal not clearly visualized, predisposing procedure incomplete decompression or inadvertent cord manipulation. Moreover, a number these...