A5021323814- Gut microbiota and health
- Inflammatory Bowel Disease
- Microscopic Colitis
- Tryptophan and brain disorders
- Cardiovascular Syncope and Autonomic Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience of respiration and sleep
APC Microbiome Institute
2021-2025
University College Cork
2020-2025
Abstract Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota with distribution inflammation. We report microbiota, host transcriptomics, epigenomics and genetics from matched inflamed non-inflamed colonic mucosa [50 Crohn’s (CD); 80 ulcerative colitis (UC); 31 controls]. Changes community-wide within-patient are linked inflammation, but we find no evidence for a distinct microbial diagnostic signature, probably due to heterogeneous host-microbe...
Crohn's disease (CD) and ulcerative colitis (UC) are chronic relapsing inflammatory bowel disorders (IBD), the pathogenesis of which is uncertain but includes genetic susceptibility factors, immune-mediated tissue injury environmental influences, most appear to act via gut microbiome. We hypothesized that host-microbe alterations could be used prognostically stratify patients experiencing relapses up four years after endoscopy. therefore examined multiple omics data, including published new...