A5019111621- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Global Cancer Incidence and Screening
- Ethics and Legal Issues in Pediatric Healthcare
- Hemoglobinopathies and Related Disorders
- Neutropenia and Cancer Infections
- Palliative Care and End-of-Life Issues
- Family Support in Illness
- Iron Metabolism and Disorders
- Acute Myeloid Leukemia Research
- Advances in Oncology and Radiotherapy
- Cancer Treatment and Pharmacology
- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
- Renal and related cancers
- Ocular Oncology and Treatments
- Pediatric Pain Management Techniques
- Global Maternal and Child Health
- Complementary and Alternative Medicine Studies
- Healthcare Systems and Reforms
- Hematological disorders and diagnostics
- Child Nutrition and Water Access
- Lymphoma Diagnosis and Treatment
- Pain Management and Opioid Use
- Health Systems, Economic Evaluations, Quality of Life
Moi University
2016-2025
AMPATH
2012-2025
Manipal Teaching Hospital
2021-2024
University of Michigan
2017-2018
Indiana University – Purdue University Indianapolis
2017
Indiana University School of Medicine
2017
St. Jude Children's Research Hospital
2017
Baptist Hospital
2017
McMaster Children's Hospital
2017
Quality of Life Research Center
2017
<h3>Background</h3> The most important reason for childhood cancer treatment failure in low-income countries is abandonment. <h3>Objective</h3> aim of this study was to explore reasons abandonment and assess the clinical condition these children. <h3>Design</h3> This a descriptive using semistructured questionnaires. Home visits were conducted interview families patients, diagnosed between January 2007 2009, who had abandoned at Moi Teaching Referral Hospital (MTRH). <h3>Results</h3> Between...
Abstract Background The principal reason for childhood cancer treatment failure in low‐income countries is abandonment, the most severe form of nonadherence. Two often neglected factors that may contribute to abandonment are as follows: (a) lack information and guidance by doctors, along with negative beliefs family friends advising parents, which contributes misconceptions regarding its treatment, (b) a widespread policy public hospitals children retained after doctor's discharge until...
Analysis of outcomes patients enrolled in the World Bleeding Disorders Registry (WBDR). 87 Hemophilia Treatment Centers around world participating WBDR. Data on 10,276 people with hemophilia demonstrate wide discrepancies care globally. Care provided low-income countries lags behind high-income by up to 40 years.
Early diagnosis and start of treatment are fundamental goals in cancer care. This study determines the time lag factors that influence to treatment. Study participants were parents childhood patients diagnosed between August 2013 July 2014 a hospital Kenya. Patient, physician, diagnosis, treatment, health care system, total delay explored using questionnaire. Demographic medical data collected from patients' records. Parents 99 interviewed (response rate: 80%). Median was 102 (9-1021) days....
Abstract Background Emphasizing timely diagnosis and treatment of cancer are important themes in pediatric management, as delays adversely impact survival. This study explores various delay types among children with determines factors that influence delays. Methods cross‐sectional was conducted at an Indonesian academic hospital. Parents newly diagnosed patients were interviewed between October 2013 September 2014 using semistructured questionnaires. Patient, physician, diagnosis, treatment,...
Vincristine (VCR) is a critical part of treatment in pediatric malignancies and associated with dose-dependent peripheral neuropathy (vincristine-induced [VIPN]). Our previous findings show VCR metabolism regulated by the CYP3A5 gene. Individuals who are low expressers metabolize slower experience more severe VIPN as compared to high expressers. Preliminary observations suggest that Caucasians nonCaucasians.Kenyan children cancer were undergoing including recruited for prospective cohort...
In low- and middle-income countries (LMICs), limited resources, suboptimal risk stratification, disproportionate patient-to-infrastructure ratio result in low survival of patients with acute myeloid leukemia (AML). A high incidence relapse, inherent to the biology, renders management arduous. The challenge treating AML LMICs is balancing intensity myelosuppressive chemotherapy, which appears necessary for cure, available supportive care, influences treatment-related mortality....
Increased awareness of cancer as a health crisis facing less developed healthcare systems has led to recent calls for increased investment in care infrastructure low resource settings. However, operational descriptions well-functioning resource-constrained settings are limited. AMPATH-Oncology is the result collaboration between North American, European, and Kenyan partners develop comprehensive model that supports screening services, treatment, palliative care. This article describes...
<h3>Setting</h3> Basic epidemiological information on childhood cancer in Western Kenya is lacking. This deficit obstructs efforts to improve the care and survival rates of children this part world. <h3>Objective</h3> Our study provides an overview patients presenting for treatment Kenya. <h3>Design</h3> A retrospective analysis was carried out using from three separate databases at Moi Teaching Referral Hospital Eldoret. All aged 0–19 years first between January 2006 2010 with a newly...
Background Survival from Wilms tumor (WT) in sub‐Saharan Africa remains dismal as a result of on‐therapy mortality and treatment abandonment. Review patients diagnosed 2008 to 2011 our Kenyan Tumor Registry showed loss follow up (LTFU) rate approaching 50%. The purpose this study was trace those LTFU, estimate the survival rate, identify risk factors for Procedure We administered comprehensive survey parents with WT at two largest referral hospitals Kenya barriers care. also telephoned...
Background Kenyan national policies for public hospitals dictate that patients are retained on hospital wards until their bills paid, but this payment process differs with or without access to National Hospital Insurance Fund (NHIF) at diagnosis. Whether these differences impact treatment outcomes has not been described. Our study explores whether childhood cancer in Kenya influenced by health‐insurance status and retention policies. Procedure This combined retrospective review of medical...
Wilms tumor is the commonest renal malignancy in childhood. Survival high-income countries approximately 90%, whereas low-income countries, it less than 50%. This study assessed treatment outcomes of patients with at a Kenyan academic hospital.We conducted retrospective medical record review all children diagnosed between 2010 and 2012. Data on various sociodemographic clinical characteristics were collected.Of 39 tumor, 41% had event-free survival, 31% abandoned treatment, 23% died, 5%...
Abstract Background ‘Treatmentabandonment’ is a common and preventable cause of childhood cancer treatment failure in low‐ middle‐income countries (LMIC). Risk factors effective interventions LMIC are reported. Poverty costs perceived as overriding causes sub‐Saharan Africa. The objective this study was to potential determinants abandonment, including aspects Africa, be better informed for planned future interventions. Methods A multicentre, prospective, observational, cohort conducted five...
Pain is often inadequately evaluated and treated in sub-Saharan Africa (SSA).We sought to assess pain levels treatment 400 hospitalized patients at a national referral hospital western Kenya, identify factors associated with treatment.Using face-validated Kiswahili versions of two single-item assessment tools, the Numerical Rating Scale (NRS) Faces Scale-Revised (FPS-R), we determined patients' levels. Additional data collected included patient demographics, prescribed analgesics,...
Abstract Introduction Western Kenya is home to approximately 24 million people, with 10 children under the age of 15 years. 1 Based on estimates cancer incidence in similar populations from around world, 1500 patients should be diagnosed pediatric each year. This article describes international collaboration that investigates potential barriers preventing effective diagnosis cancer. Methods Here, we describe a multidisciplinary and sequential approach better evaluate complex factors...
Pediatric brain tumors are understudied compared to other pediatric malignancies in low- and middle-income countries. Care delivery is inherently dependent on collaboration between multiple departments. This study aimed present baseline data of neuro-oncology care Western Kenya illustrate barriers facilitators multidisciplinary care. We performed a mixed-methods using medical records interviews. Children below age 19 years, managed for tumor at the neurosurgery or oncology departments 2015...
The WHO Global Initiative for Childhood Cancer will likely increase the number of childhood cancer survivors in resource-poor countries. This study explored survivorship care Kenya through parental reports on late effects and follow-up needs survivors. Parents Kenyan (under 18 years old) who completed treatment at least one year were interviewed using semi-structured questionnaires from 2021 to 2022. 54 interviewed. Survivors had solid tumors (52%) hematological (48%). Most received...