Adam Wright
A5066984535- Genomics and Phylogenetic Studies
- Biomedical Text Mining and Ontologies
- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- Scientific Computing and Data Management
- Research Data Management Practices
- Computational Drug Discovery Methods
- Genetics, Aging, and Longevity in Model Organisms
- Evolution and Genetic Dynamics
- Genetic diversity and population structure
- Microbial Natural Products and Biosynthesis
- CRISPR and Genetic Engineering
- Analytical Chemistry and Chromatography
- Genetics, Bioinformatics, and Biomedical Research
Ontario Institute for Cancer Research
2022-2025
Abstract WormBase has been the major repository and knowledgebase of information about genome genetics Caenorhabditis elegans other nematodes experimental interest for over 2 decades. We have 3 goals: to keep current with fast-paced C. research, provide better integration resources, be sustainable. Here, we discuss state as well progress plans moving core infrastructure Alliance Genome Resources (the Alliance). As an member, will continue interact community, develop new features needed,...
Abstract The Alliance of Genome Resources (Alliance) is an extensible coalition knowledgebases focused on the genetics and genomics intensively studied model organisms. organized as individual knowledge centers with strong connections to their research communities a centralized software infrastructure, discussed here. Model organisms currently represented in are budding yeast, Caenorhabditis elegans, Drosophila, zebrafish, frog, laboratory mouse, rat, Gene Ontology Consortium. project rapid...
Abstract The rapid increase in the number of reference-quality genome assemblies presents significant new opportunities for genomic research. However, absence standardized naming conventions and annotations across datasets creates substantial challenges. Inconsistent hinders identification correct assemblies, complicates integration bioinformatics pipelines, makes it difficult to link multiple resources. To address this, we developed a specification standardizing reference improve...
Germline and somatic mutations can give rise to proteins with altered activity, including both gain loss-of-function. The effects of these variants be captured in disease-specific reactions pathways that highlight the resulting changes normal biology. A disease reaction is defined as an aberrant which a variant protein participates. pathway contains reaction. Annotation participants provide standardized overview molecular phenotypes pathogenic amenable computational mining mathematical...
Abstract The lack of interoperable data standards among reference genome data-sharing platforms inhibits cross-platform analysis while increasing the risk provenance loss. Here, we describe FAIR bioHeaders Reference (FHR), a metadata standard guided by principles Findability, Accessibility, Interoperability and Reuse (FAIR) in addition to Transparency, Responsibility, User focus, Sustainability Technology. objective FHR is provide an extensive set serialisation methods minimum field...
Abstract Disease variant annotation in the context of biological reactions and pathways can provide a standardized overview molecular phenotypes pathogenic mutations that is amenable to computational mining mathematical modeling. Reactome, an open source, manually curated, peer-reviewed database human pathways, provides annotations for over 4000 disease variants close 400 genes ∼800 constituting ∼400 pathways. Functional proceeds from normal gene functions, through whose divergence behaviors...
The lack of interoperable data standards among reference genome data-sharing platforms inhibits cross-platform analysis while increasing the risk provenance loss. Here, we describe FAIR-bioHeaders Reference (FHR), a metadata standard guided by principles Findability, Accessibility, Interoperability, and Reuse (FAIR) in addition to Transparency, Responsibility, User focus, Sustainability, Technology (TRUST). objective FHR is provide an extensive set serialisation methods minimum field...