A5101868874- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Alkaline Phosphatase Research Studies
- Protein Kinase Regulation and GTPase Signaling
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Cardiovascular Function and Risk Factors
- Glutathione Transferases and Polymorphisms
- Cancer, Lipids, and Metabolism
- Protein Tyrosine Phosphatases
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Diseases and Immunity
- Cancer, Hypoxia, and Metabolism
- Liver Disease and Transplantation
- Ubiquitin and proteasome pathways
- Alcohol Consumption and Health Effects
- Cardiac Ischemia and Reperfusion
- Folate and B Vitamins Research
- Hepatitis C virus research
The Jikei University Hospital
2019-2020
Kumamoto Industrial Research Institute
2020
Jikei University School of Medicine
2018-2019
Hokkaido University
1992-1994
Hirosaki University
1993
Primary biliary cholangitis (PBC) patients who are refractory to ursodeoxycholic acid (UDCA) at risk for progression cirrhosis and liver failure. Bezafibrate could be an alternative second-line therapeutic option in these patients. This study aimed evaluate the long-term outcome(s) of combined UDCA bezafibrate therapy UDCA-refractory PBC identify prognostic factors.Among 445 treated with UDCA, 150 inadequately responded monotherapy received plus (median, 15 years). Data from were used this...
The mRNA levels of three phosphoseryl/phosphothreonyl protein phosphatases, PP1, PP2A and PP2C, in rat liver have been determined by Northern blot analysis various stages chemical hepatocarcinogenesis using a Solt‐Farber model. Five weeks after administration diethyl‐nitrosamine, the PPl α , PP2C were elevated 8, 29 11 times, respectively, as compared to those control livers. However, primary hepatoma induced according model, all phosphatases dramatically decreased normal or even much lower...
Opportunities to treat older patients with hepatitis C virus infection have increased. We investigated the efficacy and safety of glecaprevir/pibrentasvir in HCV aged ≥75 years.We retrospectively evaluated 131 treated at nine institutions Japan. The were divided into two groups according their age: elderly group (n = 43, years) younger 88, <75 years). compared clinical characteristics, virologic response adverse events between groups. predictive factors for also assessed.The presence...
We have examined the mRNA levels for catalytic subunits of three phosphoseryl/phosphothreonyl protein phosphatases PP1alpha, PP2Aalpha and PP2C by Northern blot analysis in primary hepatomas poorly differentiated ascites hepatomas. The were compared with those regenerating rat livers. In livers, at 24 h after partial hepatectomy elevated 5, 14 10 times as to control But induced 3'-methyl-4-dimethyl-aminoazobenzene(3'-Me-DAB), 2-acetylaminofluorene(2-AAF), Solt-Farber model, almost same On...
Objective We aimed to investigate the association between digit symbol test (DST) and clinical characteristics, including nutritional status of liver cirrhosis patients. Methods Fifty-nine cirrhotic patients without a history overt hepatic encephalopathy were retrospectively evaluated. examined neuropsychological abnormalities (NPAs) using DST. also estimated detailed Food Frequency Questionnaire (FFQ). The divided into two groups according their DST status: with normal scores (DST-Nor...
Nuclear type 1 protein phosphatase (PP1) activity in primary culture of EGF‐stimulated hepatocytes was significantly and transiently increased at the G /S transition, being about 2.5‐fold, while that non‐stimulated showed almost no change. On other hand, non‐nuclear PP1 gradually until but difference between hepatocytes. Under growth‐inhibited conditions presence TGFβ1, increase nuclear completely suppressed, whereas little affected. Such close correlation growth factor‐induced positive or...
Abstract Background Mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies toxic aldehydes including those generated during ischemia/reperfusion (I/R) injury in acute myocardial infarction. The deficient variant ALDH2 genotype (ALDH2*2) is prevalent among East Asians. We examined whether ALDH2*2 exacerbates I/R Japanese patients with ST-segment elevation infarction (STEMI) utilizing Mendelian randomization. Methods and results study subjects comprised 248 STEMI (187 men 61 women, mean age...