Christian Wrede
A5071924348- Emergency and Acute Care Studies
- Trauma and Emergency Care Studies
- COVID-19 and Mental Health
- Healthcare Technology and Patient Monitoring
- Dementia and Cognitive Impairment Research
- Sepsis Diagnosis and Treatment
- Psychological Well-being and Life Satisfaction
- Health and Medical Studies
- Non-Invasive Vital Sign Monitoring
- Medical and Health Sciences Research
- Digital Mental Health Interventions
- Pancreatic function and diabetes
- Quality and Safety in Healthcare
- Respiratory Support and Mechanisms
- Technology Use by Older Adults
- Geriatric Care and Nursing Homes
- Renal function and acid-base balance
- Hemodynamic Monitoring and Therapy
- Medical Practices and Rehabilitation
- Diabetes and associated disorders
- Context-Aware Activity Recognition Systems
- Gastrointestinal Bleeding Diagnosis and Treatment
- Health disparities and outcomes
- Adrenal Hormones and Disorders
- Cardiac Arrest and Resuscitation
University of Twente
2020-2025
Helios Hospital Berlin-Buch
2014-2024
German Society of Medical Intensive Care and Emergency Medicine
2011-2022
Oldenburger Institut für Informatik
2021
University Hospital Regensburg
2005-2012
Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin
2011
University of Regensburg
2004-2010
TU Dortmund University
2006-2010
Ruhr University Bochum
2006-2010
Deutsche Forschungsgemeinschaft
2010
Background: Public health recommendations and governmental measures during the COVID-19 pandemic have resulted in numerous restrictions on daily living including social distancing, isolation home confinement. While these are imperative to abate spreading of COVID-19, impact behaviours lifestyles at is undefined. Therefore, an international online survey was launched April 2020, seven languages, elucidate behavioural lifestyle consequences restrictions. This report presents results from first...
Public health recommendations and governmental measures during the new coronavirus disease (COVID-19) pandemic have enforced numerous restrictions on daily living including social distancing, isolation, home confinement. While these are imperative to mitigate spreading of COVID-19, impact psychosocial is undefined. Therefore, an international online survey was launched in April 2020 elucidate behavioral lifestyle consequences COVID-19 restrictions. This report presents preliminary results...
AMA Ammar A, Trabelsi K, Brach M, et al. Effects of home confinement on mental health and lifestyle behaviours during the COVID-19 outbreak: Insight from ECLB-COVID19 multicenter study. Biology Sport. 2021;38(1):9-21. doi:10.5114/biolsport.2020.96857. APA Ammar, A., Trabelsi, K., Brach, M., Chtourou, H., Boukhris, O., & Masmoudi, L. (2021). Sport, 38(1), 9-21. https://doi.org/10.5114/biolsport.2020.96857 Chicago Achraf, Khaled Michael Hamdi Omar Liwa Bassem Bouaziz 2021. "Effects study"....
Public health recommendations and government measures during the COVID-19 pandemic have enforced restrictions on daily-living. While these are imperative to abate spreading of COVID-19, impact mental emotional wellbeing is undefined. Therefore, an international online survey (ECLB-COVID19) was launched April 6, 2020 in seven languages elucidate wellbeing.
Symptoms of psychological distress and disorder have been widely reported in people under quarantine during the COVID-19 pandemic; addition to severe disruption peoples' daily activity sleep patterns. This study investigates association between physical-activity levels patterns quarantined individuals. An international Google online survey was launched April 6th, 2020 for 12-weeks. Forty-one research organizations from Europe, North-Africa, Western-Asia, Americas promoted through their...
The COVID-19 lockdown could engender disruption to lifestyle behaviors, thus impairing mental wellbeing in the general population. This study investigated whether sociodemographic variables, changes physical activity, and sleep quality from pre- during were predictors of change quarantined older adults.
Pancreatic β-cell mitogenesis is increased by insulin-like growth factor I (IGF-I) in a glucose-dependent manner. In this study it was found that alternative nutrient fuels to glucose, pyruvate, and glutamine/leucine independently induced provided platform for IGF-I induce INS-1 cell DNA synthesis the absence of serum. contrast, long chain FFA (≥C12) inhibited 15 mm glucose-induced [3H]thymidine incorporation (±10 nm IGF-I) 95% or more within 24 h above 0.2 complexed 1% BSA (K0.5...
Abstract Adiponectin (APM) is an adipocyte-derived adipokine with immunosuppressive, antidiabetic, and antiatherosclerotic properties. Low molecular weight (LMW)- higher (HMW)-APM circulate in the serum activate different signaling pathways. We were interested to see whether LMW-APM exerts effects on monocytic cells compared HMW isoform. Therefore, of recombinant produced insect APM from eukaryotic containing forms investigated respect apoptosis inflammation. LMW- HMW-APM induce...
Free fatty acids (FFA) have been reported to reduce pancreatic β-cell mitogenesis and increase apoptosis. Here we show that the FFA, oleic acid, increased apoptosis 16-fold in line, INS-1, over a 18-h period as assessed by Hoechst 33342/propidium iodide staining caspase-3 -9 activation, with negligible necrosis. A parallel analysis of phosphorylation activation protein kinase B (PKB) showed this was reduced presence FFA correlated incidence At stimulatory 15 mm glucose and/or added...
To validate cardiovascular alarms in critically ill patients an experimental setting by generating a database of physiologic data and clinical alarm annotations, report the current rate their validity. Currently, monitoring parameters is performed systems with high sensitivity, but low specificity. As consequence, multitude potentially negative impact on quality care generated.Prospective, observational, study.Medical intensive unit university hospital.Data from different medical were...
Unexplained hepatic iron overload with increased serum ferritin (SF) values has been associated the insulin resistance syndrome (IRS), defined by presence of one or more following criteria: body mass index (BMI), diabetes, hyperlipidemia hypertension. However, as yet association between IRS and SF in a representative population not investigated.The study subjects participated nationwide epidemiological survey on metabolic disorders adult German population. The 1200 probands included this are...
Glucose can activate the mitogen-activated kinases, Erk-1/2, and ribosomal-S6 kinase, p70S6K, in β-cells, contributing to an increase mitogenesis. However, signaling mechanism by which glucose induces Erk-1/2 p70S6K phosphorylation activation is undefined. Increased metabolism increases [Ca2+]i [cAMP], it was investigated if these secondary signals were linked glucose-induced pancreatic β-cells. Blocking Ca2+ influx with verapamil, or inhibiting protein kinase A (PKA) H89, prevented...
Abstract Background Public health recommendations and governmental measures during the COVID-19 pandemic have enforced numerous restrictions on daily living including social distancing, isolation home confinement. While these are imperative to abate spreading of COVID-19, impact behaviours lifestyle at is undefined. Therefore, an international online survey was launched in April 2020 seven languages elucidate behavioral consequences restrictions. This report presents preliminary results from...
Respiratory acidosis can become a serious problem during protective ventilation of severe lung failure. A pumpless arteriovenous interventional assist (iLA) for extracorporeal carbon dioxide removal has been used increasingly to control critical respiratory situations. The present study sought evaluate the factors determining efficacy iLA and calculate its contribution gas exchange. In cohort 96 patients with acute distress syndrome, haemodynamic parameters, oxygen consumption production as...
Online‐monitoring systems in intensive care are affected by a high rate of false threshold alarms. These caused irrelevant noise and outliers the measured time series data. The alarm rates can be lowered separating relevant signals from online, such way that signal estimations, instead raw measurements, compared to limits. This paper presents clinical validation study for two recently developed online filters. filters based on robust repeated median regression moving windows varying width....
Abstract Background Although recognised as effective measures to curb the spread of COVID-19 outbreak, social distancing and self-isolation, have been suggested generate burden throughout population. To provide scientific data help identify risk-factors for psychosocial strain during an international cross-disciplinary online survey was circulated in April 2020. This report outlines mental, emotional behavioural consequences home confinement. Method Thirty-five research organisations from...
Emergency care in Germany is transition. departments (EDs) treat their patients based on symptoms and acuity. However, this perspective not reflected claims data. The aim of the AKTIN project was to establish an Department Data Registry as a data privacy-compliant infrastructure for use routine medical
Abstract Background During the COVID-19 pandemic and associated public health social measures, decreasing patient numbers have been described in various healthcare settings Germany, including emergency care. This could be explained by changes disease burden, e.g. due to contact restrictions, but also a result of utilisation behaviour population. To better understand those dynamics, we analysed routine data from departments quantify consultation numbers, age distribution, acuity day hour...
Zusammenfassung Die Notaufnahmen deutscher Krankenhäuser sind ein zentraler Anlaufpunkt für über 20 Millionen Notfallpatienten pro Jahr. Um eine hochwertige Patientenversorgung sicherstellen zu können, personelle, apparative und infrastrukturelle Voraussetzungen erforderlich, die nur bedingt im Beschluss des Gemeinsamen Bundesausschusses (G-BA) einem gestuften System von Notfallstrukturen an Krankenhäusern 2018 festgeschrieben sind. Darüber hinaus gibt es bislang in Deutschland keine...
Background Due to a growing shortage in residential care, people with dementia will increasingly be encouraged live at home for longer. Although prefer extended independent living, this also puts more pressure on both their informal and formal care networks. To support (in)formal caregivers of dementia, there is interest unobtrusive contactless in-home monitoring technologies that allow remotely monitor the lifestyle, health, safety recipients. Despite potential, these solutions only viable...
(1) Background: The COVID-19 pandemic forced people from all around the globe to strongly modify their daily routines, putting a significant strain on social aspects of lives. While first wave was very challenging time in countries, it is still uncertain whether various lockdown intensities and infection rates differed regarding psychosocial impact. This work therefore aimed investigate (i) effects home confinement two European countries that underwent different intensities: Italy...