The current study aims to evaluate the geotechnical parameters required for engineering construction. For this purpose, four seismic refraction profiles were implemented at College of Science site (a building attached deanship) University Babylon, south Baghdad Governorate, describe soil. Both compressional (P) and shear (S) waves detected, processed, interpreted. Many important calculated depending on values wave velocities (Vp Vs.). These consist Poisson's ratio (σ), Material index (Im),...

The unique anatomy and flexibility of the cervical spine (C-spine) pose a risk injury. Trauma to C-spine encompasses diverse range injuries, ranging from minor muscular strains life-threatening fractures dislocations associated with spinal cord lesions. This case report concerns man in his seventies who presented emergency department immediately after road traffic collision only laceration on forehead. patient was discharged thorough evaluation returned next day, reporting left-hand...

Abstract Aims To compare early de-escalation of dual antiplatelet therapy (DAPT) (1–3 months) to monotherapy with either P2Y12 inhibitor or aspirin vs. 12 months DAPT after percutaneous coronary intervention (PCI) drug-eluting stent (DES). Methods and results Electronic databases Medline, Embase, Cochrane library were searched through February 2020 identify randomized controlled trials. A Bayesian network meta-analysis was conducted random effects model. The main endpoints interest...

Free radicals are particles that have an unpaired electron.If they produced in high level our bodies, can cause damage to lipids, proteins, and DNA.Antioxidants any compounds incorporate free a safe way, cease the reaction, switch them risk-free molecule by donating proton.The infectious diseases among chief causes of death worldwide, antimicrobial resistance has been regularly reported globally.Thus, these complications necessitate investigation for new therapies with potential antioxidant...

Reactive oxygen species (ROS) in the form of free radicals (superoxide, singlet oxygen, hydroxyl radical) and neutral molecules (hydrogen peroxide) play an significant role development many serious diseases. If they produced high level can produce damage to lipids, proteins, DNA. Antioxidants are defined as scaffolds that suspend, prevent or eliminate oxidative target vital when introduced low concentrations. Infectious diseases among chief causes death worldwide, antimicrobial resistance...

In the Beyond-5G (B5G) and sixth generation (6G), several advanced techniques are based on high-frequency millimeter-wave wireless communications. This paper proposes design of a novel B5G 6G radio access network (RAN) architecture. architecture aims to be key enabling factor for significantly increasing capacity, promoting deployment new services, integrating with evolution previous cellular Furthermore, proposed is adaptable various characteristics communication. It leverages allocation...

e15583 Background: Gallbladder cancer (GBC) is a rare tumor that often presents at an advanced stage and associated with poor prognosis. Little known about the incidence patterns factors influence outcomes in GBC. Methods: GBC cases diagnosed between 1973 2012 were identified using Surveillance, Epidemiology End Results (SEER) database annual percent change (APC) rates calculated for same time period. A retrospective cohort of 16547 patients from to 2008 was further analyzed Chi-square test...

Objective: The purpose of this study was to synthesize three new derivatives metoclopramide by diazotization and replacement reactions then quantify in vitro their protection effects on blood cholinesterases using chlorpyrifos as a potent inhibitor. methods: were synthesized via Sandmeyer reaction, the chemical structures these identified physico-chemical spectroscopic (U.V. FTIR) techniques. Results conclusion: results evaluation human inhibition against indicated that (OH) functional group...

In vitro inhibition of human plasma and erythrocyte cholinesterase activities by the strong inhibitor chlorpyriphos (organophosphate) weak inhibitors (donepezil, metoclopramide, diphenhydramine) in different concentrations was evaluated. The protective ability each one alone with a combination two them against inhibitory action also detected. results showed patterns depending on its concentration when used or within combination. When testing ability, differed for combinations, own to bind...

Objective:To evaluate the role of fluorine atom in modern drug synthesis. Methods: Different types fluorinated were prepared, antimicrobials, antivirals, F-NSAIDs, peptides and protein Results: Recent developments future prospects medicinal chemistry chemical biology. The extraordinary potential - containing biologically relevant molecules antimicrobial or antivirial agents, peptide chemistry, biology, pharmacology, discovery as well diagnostic therapeutic applications, was recognized by...

The inhibitory effect for human plasma and erythrocyte cholinesterase activity by six drugs already known as an enzyme inhibitors (Cimetidine, Ciprofloxacin, Donepezil, Sildenafil, Erythromycin, Chlorpheniramine) was tested in vitro. affinity toward the system evaluated using different concentrations of investigated drugs. activities were determined modified electrometric method. Each drug showed ability to inhibit depending on its concentration selectivity either or cholinesterase; only...

The beta-lactams are recognized as effective antibiotics for treating infections, yet bacterial production of β-lactamase, which hydrolyzes the beta-lactam ring, can render these drugs inactive. Combining with a β-lactamase inhibitor, such clavulanic acid, mitigates this resistance. In docking study involving Temoniera-1 (TEM-1), 1pzp, we induced synthesis eight amide compounds by reacting acid chloride derivatives sulphathiazol or oxadiazol amine, forming an bond. newly synthesized were...

Epigastric pain and vomiting are common presentations associated with various causes of acute abdomen. Acute abdomen encompasses a range different pathologies, epigastric narrowing the differential diagnosis to conditions such as pancreatitis, bowel obstruction, cholecystitis, gastritis, coronary syndrome (ACS), peptic ulcer disease, gastric ulcers duodenal with/without perforation. This is case male patient in his 80s who came emergency department symptoms generalized abdominal pain,...

The serious GIT side effects of NSAIDs, due to their carboxylic acid groups, aroused the attention researchers manipulate such drugs. Conjugates with NSAIDs are a strategic, way for both augmenting anti-inflammatory activities and reducing effects. Natural or synthetic coumarins interesting motifs activity. scope this work was conjugate (ibuprofen, diclofenac, mefenamic acid, ketorolac indomethacin) various substituted through an ester amide linkages using virtual screening molecular docking...

β-Lactams, such as penicillins and cephalosporins, have long been recognized the most effective antibiotics for treatment of infectious diseases. However, major limitation to their effectiveness is bacterial production β-lactamase enzymes, which hydrolyze β-lactam ring in these drugs, rendering them inactive. To overcome this resistance mechanism, inhibitors, clavulanic acid, are commonly used combination with β-lactams. By inhibiting action inhibitors restore efficacy antibiotics. In recent...

The ADME study was conducted to ensure their drug-likeness properties before testing biological activities. docking results represent 8 amide compounds were better than the standard antibacterial agents and after they synthesized chemical structures characterized, represents acceptable drug likeness outcome. These have no BBB penetration GI crossing ability. will give a good chance for tested be available in peripheral circulation not produce any unwanted central side effects, if accepted as...

Objectives: β-Lactams are the most successful antibiotics for management of infectious diseases. Unfortunately, bacterial production β-lactamase that hydrolyzes β-lactam ring can inactivate these drugs. The use inhibitors like (clavulanic acid) in combination with β-lactams may reduce this inactivation. prevalent phenotype is TEM-1 class A released by Gram-positive and Gram-negative bacteria.Methods: docking study lead to synthesize new 5 monobactam compounds as acid chloride derivatives...