BACKGROUND The efficacy and safety of transarterial chemoembolization (TACE) plus lenvatinib in patients with hepatocellular carcinoma (HCC) portal vein tumor thrombus (PVTT) have not been evaluated. METHODS In this open‐label, single‐center, randomized trial (ClinicalTrials.gov identifier: NCT04127396), participants previously untreated HCC type I‐IV PVTT were 1:1 to receive TACE (arm L; orally once daily, 12 mg for body weight ≥60 kg or 8 <60 kg) sorafenib S; 400 twice daily 28‐day...

Maternal nutrition is important for the risk of offspring to develop insulin resistance and adiposity later in life. The study was undertaken determine effects maternal butyrate supplementation on lipid metabolism sensitivity skeletal muscle. rats, fed a control diet or (1% sodium butyrate) throughout gestation lactation, studied at weaning 60 days age. dams had higher HOMA-insulin impaired glucose tolerance. This associated with elevated mRNA protein expressions lipogenic genes decreased...

Objective: We assessed the efficacy and safety of transarterial chemoembolization (TACE) in combination with lenvatinib plus programmed death receptor-1 (PD-1) signaling inhibitors (camrelizumab or sintilimab) unresectable hepatocellular carcinoma (uHCC). Methods: In this retrospective study, patients uHCC were pretreated for 1 to 2 weeks before TACE. Camrelizumab sintilimab initially administered intravenously week after TACE a 21-day cycle. Primary objectives objective response rate (ORR)...

Hepatocellular carcinoma (HCC) patients complicated with portal vein tumor thrombus (PVTT) exhibit poor prognoses and treatment responses.

The meat quality of different pig breeds is associated with their muscle tissue physiological processes, which involves a large variety genes related fat and energy metabolism. Understanding the differences biological processes after slaughter helpful to reveal development breeds. Therefore, eight native Large Black pigs (BP), high content in meat, seven cross-bred commercial (CP), had feed efficiency lean were used investigate RNA transcriptomes. average daily gain (ADG) hot carcass weight...

Abstract Background The C‐reactive protein (CRP)/albumin (Alb) ratio (CAR) is a basic inflammatory factor that has been related to poor survival of patients with various tumors. Our research retrospectively examined the relationship between CAR and prognosis hepatocellular carcinoma (HCC). Methods This study included 172 HCC who were treated transcatheter arterial chemoembolization (TACE) radiofrequency ablation (RFA). Results was weakly neutrophil/lymphocyte (NLR, r = .159, P .037)...

Sarcopenia has gained considerable attention in the context of hepatocellular carcinoma, as it been correlated with a poorer prognosis among patients undergoing sorafenib or lenvatinib treatment for carcinoma (HCC). The clinical significance sarcopenia first-line advanced HCC treated and programmed death-1 (PD-1) inhibitors needs to be clarified.

Hepatocellular carcinoma (HCC) ranks fifth among malignancies globally. Previous studies have shown that systemic inflammatory response, platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte (LMR) are associated with poor prognosis of various types cancer.Radiofrequency ablation (RFA) was performed using an internal cooling electrode a 2- or 3-cm exposed tip. The LMR calculated as the lymphocytes to monocytes. In order explore influence pretreatment PLR on survival HCC patients...

The CRAFITY score is mainly utilized for hepatocellular carcinoma (HCC) patients receiving atezolizumab and bevacizumab, with little investigation in its predictive capacity alternative regimens, such as lenvatinib programmed cell death protein 1 (PD-1) inhibitors, which are widely Chinese clinical practice. To look at the significance of HCC taking PD-1 inhibitors. retrospective consisted 192 incurable who received inhibitors between January 2018 2022. Patients were stratified according to...

Background and purpose: Patients with unresectable hepatocellular carcinoma (uHCC) Child-Pugh grade B face limited treatment options poor outcomes. This study aims to evaluate whether the effect safety of combining tyrosine kinase inhibitors (TKIs) progressive disease (PD)-1 in uHCC patients B7 (CP7) B8/9 (CP8/9) differ. Methods: multicenter retrospective included 179 (CP7 group: n = 106; CP8/9 73), receiving a combination lenvatinib/sorafenib/other TKIs PD-1 between December 2020 March...

This study attempted to comprehensively assess the clinical outcomes of cases with progressive HCC (pHCC) undergoing treatment TKI and ICI in conjunction TACE, as compared combination TACE alone. From March 2019 January 2022, this cohort comprised 82 who received 52 were treated plus The propensity scores was used mitigate selection bias. multivariate analysis further reinforced that liver cirrhosis (HR = 1.233, 95% CI: 1.024-1.484, P 0.027), tumor diameter 1.283, 1.086-1.515, 0.003),...

Patients with advanced intrahepatic cholangiocarcinoma (iCCA) have a poor prognosis and substantial unmet clinical need. The study was aimed to investigate the efficacy safety of sintilimab combined lenvatinib for iCCA in second-line setting.The patients at multiple centers, who progressed after first-line chemotherapy or could not tolerate chemotherapy, were treated combination plus lenvatinib. primary endpoint time progression (TTP), secondary endpoints included tumor objective response...

Hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) portends a worse prognosis. The objective of this study was to compare the efficacy percutaneous radiofrequency ablation (RFA) combined transarterial chemoembolization (TACE) plus sorafenib that most commonly utilized regimen TACE in large HCCs type I/II PVTT.An open-label, single-center, prospective, randomized trial participants tumors ≥5 cm and PVTT performed. Participants previously untreated were divided into two...

The combination of immune checkpoint inhibitors (ICIs) and anti-angiogenic agents has shown promising efficacy in unresectable hepatocellular carcinoma (HCC), but until now no clinical prognostic models or predictive biomarkers have been established.From 2016 to 2021, a total 258 HCCs treated with ICIs tyrosine kinase (TKIs) were retrospectively enrolled, as the study cohort. Patients' baseline data was extracted by least absolute shrinkage selection operator (LASSO) Cox regression. Finally,...

Purpose: Neutrophil-to-lymphocyte ratio (NLR) is considered as a prognostic factor in some patients with hepatocellular carcinoma (HCC). This has not been extensively examined young HCC patients. The objective of this study to assess whether pre-treatment NLR could predict the survival implemented minimally invasive treatment. Methods: Young treated by transarterial chemoembolization (TACE) combined radiofrequency ablation (RFA) at our institutes from 2008 2017 were retrospectively reviewed....

Currently, there are a few treatment options for unresectable hepatocellular carcinoma (HCC) after progression following sorafenib (SOR) therapy, but with limited benefit. The purpose of this study was to investigate the efficacy and safety tyrosine kinase inhibitors (TKIs) combined immune checkpoint (ICIs) as second-line treatment.From May 2018 2021, total 93 HCCs who failed SOR were included in divided into TKI group (n = 37) TKI-ICI 56). Overall survival (OS), progression-free (PFS),...

Abstract Background Serum alpha‐fetoprotein (AFP) level is normal in 30–40% of hepatocellular carcinoma (HCC) patients, and knowledge on its characteristics clinical outcome limited. The purpose this observational study was to determine the presentation, biological behavior HCC patients with AFP level. Methods Data 112 consecutive were analyzed retrospectively. Statistical analysis including survival factors associated serum performed by Kaplan‐Meier method t ‐test, respectively. Results...

<title>Abstract</title> <bold>Background: </bold>Unresectable hepatocellular carcinoma (uHCC) patients with Child-Pugh grade B have limited treatment options and poor outcomes. <bold>Methods: </bold>Patients uHCC Child-pugh who received lenvatinib plus PD-1 inhibitors or sorafenib at one of three centers were retrospectively reviewed. These divided into two subgroups: B7 (Group A, n =106) another B/9 B, = 73). Overall survival (OS) was defined as the primary endpoint. Secondary endpoints...

The combination therapy of transarterial chemoembolization and radiofrequency ablation (TACE-RFA) shows promising efficacy in large hepatocellular carcinoma (HCC). Data on the clinical safety TACE-RFA for HCC with barcelona clinic liver cancer (BCLC) stage C are lacking China.To determine large, advanced HCC.Patients BCLC who were treated or TACE alone at our institute from August 2008 to January 2017 retrospectively reviewed. complications observed. associations between overall survival...

Objective: To investigate the safety and efficacy of radiofrequency ablation (RFA) with percutaneous iohexol-ethanol injection (PIEI), compared RFA plus transcatheter arterial chemoembolization (TACE) for patients primary liver cancer(PLC)in high-risk locations. Methods: From January 2012 to December 2014, 54 PLC in locations were enrolled. They divided into Group A (RFA combined PIEI) B TACE). The adverse events assessed. Results: had 74 lesions There 26 cases 40 A, 28 34 B. complete rate...

Abstract Early piglet mortality due to chilling is a leading cause of economic loss in swine production. Non-shivering thermogenesis can be used by piglets increase survivability through the utilization brown adipose tissue (BAT). Recent studies suggest metformin hydrochloride induces “browning,” or transdifferentiation, white adipocytes into and increases BAT formation. Uncoupling proteins (UPC) are principal markers BAT. Sow treatment with may deposition neonatal piglets. The objective...