A5009562535- Neonatal Respiratory Health Research
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Nuclear Physics and Applications
- Reproductive Health and Contraception
- COVID-19 Impact on Reproduction
- Infant Development and Preterm Care
- Fungal and yeast genetics research
- Clinical Nutrition and Gastroenterology
- Global Maternal and Child Health
- Maternal and fetal healthcare
- Inorganic and Organometallic Chemistry
- Reproductive System and Pregnancy
- Parkinson's Disease Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Inorganic Fluorides and Related Compounds
- Neuroscience of respiration and sleep
- Climate Change and Health Impacts
- Maternal and Perinatal Health Interventions
- Infant Nutrition and Health
- Pharmaceutical Practices and Patient Outcomes
- Demographic Trends and Gender Preferences
- Quality of Life Measurement
- Biomedical Text Mining and Ontologies
University of California, San Francisco
2013-2025
W. M. Keck Foundation
2024
San Francisco Department of Public Health
2024
Universidad Católica de Santa Fe
2023
University of California System
2022
QB3
2020
Introduction: Our understanding of the association between coronavirus disease 19 (COVID-19) and preterm or early term birth among racially ethnically diverse populations people with chronic medical conditions is limited.Methods: We determined COVID-19 (PTB) live births documented by California Vital Statistics certificates July 2020 January 2021 (n=240,147). used best obstetric estimate gestational age to classify as very (VPTB, <32 weeks), PTB (< 37 (37 38 (39-44 each confer independent...
Abstract Background Preterm birth (PTB) is the leading cause of infant mortality. Risk for PTB influenced by multiple biological pathways, many which are poorly understood. Some PTBs result from medically indicated labor following complications hypertension and/or diabetes, while others spontaneous with unknown causes. Previously, investigation potential risk factors has been limited a lack data on maternal medical history and difficulty classifying as or spontaneous. Here, we leverage...
Importance Preterm birth (PTB) (gestational age &amp;lt;37 weeks) is a major cause of infant mortality and morbidity in the US marked by racial ethnic socioeconomic inequities. Further research needed to elucidate association risk protective factors with trends PTB rates related Objective To describe inequities as well over past decade population–based cohort. Design, Setting, Participants This retrospective cohort study singleton live births California from January 1, 2011, December 31,...
Background: Our understanding of the association coronavirus disease 19 (COVID-19) and preterm or early term birth among racially ethnically diverse populations those with chronic medical conditions is limited. Methods: We examined relationship between COVID-19 (PTB) live births documented by California Vital Statistics certificates July 2020 January 2021 (n=240,147). used best obstetric estimate gestational age to classify as very (VPTB, <32 weeks), PTB (< 37 (37 38 (39-44 each confer...
One in ten neonates are admitted to neonatal intensive care units, highlighting the need for precise interventions. However, application of artificial intelligence (AI) guiding remains underexplored. Total parenteral nutrition (TPN) is a life-saving treatment preterm neonates; however, implementation therapy its current form subjective, error-prone and resource-consuming. Here, we developed TPN2.0—a data-driven approach that optimizes standardizes TPN using information collected routinely...
Abstract Background On January 31st, 2023, the province of British Columbia (BC), Canada, was granted a federal exemption allowing adults (aged 18 +) to possess up 2.5 g select illicit drugs. The will be in place for three years (2023–2026), marking first formal decriminalization drug policy reform Canada. BC’s initiative is premised on several goals. This project seeks evaluate each these goals and their individual combined contributions determine overall success this policy. Methods...
Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, part due to challenge probing protein structures living cells. Here, we use deep mutational scanning investigate a toxic conformation α-synuclein, dynamic linked Parkinson's disease, responds perturbations proteostasis. In context course for graduate students UCSF Integrative Program Quantitative Biology,...
While pollution from vehicle sources is an established risk factor for preterm birth, it unclear whether distance of residence to the nearest major road or related measures like density represent useful characterising risk.To determine proximity (including road, and traffic volume) are more factors birth than other vehicle-related particulate matter <2.5 μm in diameter (PM2.5 ) diesel (diesel PM)).This retrospective cohort study included 2.7 million births across state California 2011-2017;...
Introduction There is limited literature on neonatal mortality in humanitarian emergencies. We estimated and stillbirth rates; determined whether an association exists between proximity to a secondary health facility or stillbirth; tested the correlation number of facilities camp rates Rohingya refugee camps Bangladesh. Methods conducted prospective community-based surveillance 29 out 34 September 2017 December 2018, covering approximately 811 543 refugees with 19 477 live births. linked...
<title>Abstract</title> Recurrent pregnancy loss (RPL), defined as 2 or more losses, affects 5-6% of ever-pregnant individuals. Approximately half these cases have no identifiable explanation. To generate hypotheses about RPL etiologies, we implemented a case-control study comparing the history over 1,600 diagnoses between and live-birth patients, leveraging University California San Francisco (UCSF) Stanford electronic health record databases. In total, our included 8,496 (UCSF: 3,840,...
Abstract Background Preterm infants suffer from respiratory morbidity especially during the first year of life. Objective To investigate association air quality and sociodemographic indicators on hospital admission rates for causes. Methods This is a retrospective cohort study. We identified all live‐born preterm in California 2007 to 2012 population‐based administrative data set linked them measuring several at census tract level. All predictors were divided into quartiles (first quartile...
The 2019 novel coronavirus disease (COVID-19) pandemic caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) continues to spread and worsen in many parts of world. As grows, it is especially important understand how virus are affecting pregnant women infants. While early data suggested that being infected with did not increase risk adverse pregnancy or infant outcomes, as more information has emerged, become clear risks for some outcomes increased (e.g., preterm birth, cesarean...
Abstract Recurrent pregnancy loss (RPL), defined as 2 or more losses, affects 5-6% of ever-pregnant individuals. Approximately half these cases have no identifiable explanation. To generate hypotheses about RPL etiologies, we implemented a case-control study comparing the history over 1,600 diagnoses between and live-birth patients, leveraging University California San Francisco (UCSF) Stanford electronic health record databases. In total, our included 8,496 (UCSF: 3,840, Stanford: 4,656)...
Abstract Background Major depressive disorder and exposure to antidepressants during pregnancy have been previously associated with preterm birth (PTB). However, the reported results are difficult interpret due inherent confounding by indication bias. We aimed estimate disentangled effects of maternal depression on risk PTB using data from electronic health records (EHRs). Methods This is a population-based retrospective cohort study, utilizing primary care EHR. The included 216,070...