A5075505160- Lung Cancer Treatments and Mutations
- Click Chemistry and Applications
- PI3K/AKT/mTOR signaling in cancer
- Colorectal Cancer Treatments and Studies
- Radical Photochemical Reactions
- Chronic Lymphocytic Leukemia Research
- Organic Chemistry Cycloaddition Reactions
- Nutrition and Health in Aging
- Pharmacological Effects of Natural Compounds
- Acne and Rosacea Treatments and Effects
- Luminescence and Fluorescent Materials
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Polydiacetylene-based materials and applications
- Microtubule and mitosis dynamics
- Supramolecular Self-Assembly in Materials
- Ubiquitin and proteasome pathways
- Chronic Myeloid Leukemia Treatments
- Advancements in Transdermal Drug Delivery
- GDF15 and Related Biomarkers
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Renal Diseases and Glomerulopathies
- Immune cells in cancer
University of Oklahoma Health Sciences Center
2020-2025
Shuguang Hospital
2020-2025
Shanghai University of Traditional Chinese Medicine
2018-2025
Beijing Hospital
2015-2024
Second Affiliated Hospital of Zhejiang University
2021-2024
Qingdao University
2018-2024
Beijing Technology and Business University
2021-2024
Xuzhou Medical College
2021-2024
Qingdao Municipal Hospital
2018-2024
Northwestern Polytechnical University
2024
Abstract Recently Food and Drug Administration (FDA)-approved pralsetinib (BLU-667) selpercatinib (LOXO-292) are RET-selective protein tyrosine kinase inhibitors for treating RET-altered cancers, but whether they have distinct activity was unknown. The L730V/I mutations at the roof of solvent-front site RET were identified as strongly resistant to not selpercatinib. Selpercatinib effectively inhibited these mutants KIF5B-RET(L730V/I) oncogene-driven tumors.
Abstract Background Alterations in the secretion and composition of skin surface lipids (SSL) are closely associated with development acne. Lipidomics is a useful tool to analyse SSL different types Our previous study found that phosphatidylserine triacylglycerols dominate changes male acne infantile acne, respectively. However, as well specific female patients remain be investigated. Objectives To compare profile women healthy discuss involvement differential development. Methods Systematic...
Summary The purpose of the present study was to evaluate effect Happy 10 programme on promotion physical activity, growth and development primary school students, obesity control prevention. Two similar schools from one district Beijing, China were selected, as an intervention other a school. A implemented at least once every day in for two semesters, whereas no adopted information energy expenditure duration activity collected by validated 7‐day questionnaire. Height weight measured trained...
Herein, we report an iridium-catalyzed asymmetric C–H activation combined with a desymmetrization strategy for synthesizing distal biaxial atropisomers excellent stereoselectivity, displaying promising photophysical and chiroptical properties.
Background: The anti-tumor effects of Traditional Chinese Medicine has been recognized in regulating the tumor microenvironment. Jianpi Jiedu Recipe (JPJDR) is clinically effective enhancing chemotherapy efficacy Colorectal Cancer (CRC) treatment and significantly improved quality life CRC patients. However, its therapeutic mechanism remains to be investigated Material Methods: active compounds each herb JPJDR were obtained from HIT2.0 HERB databases supported by evidence literature....
To investigate the effects of Aurora kinase A (AURKA) on tumor microenvironment colorectal cancer (CRC) and to predict active compounds in Chinese herbs that can target AURKA. Based transcriptomic data clinical information from 380 CRC tissues 51 paracancerous The Cancer Genome Atlas (TCGA) database, infiltration different cells was analyzed using xCell binding with AURKA predicted through molecular docking. expression significantly upregulated compared (P < 0.05), patients high had shorter...
Abstract The REarranged during Transfection (RET) kinase is an oncoprotein and a therapeutic target for RET alteration-positive cancer. Two RET-selective protein tyrosine inhibitors, selpercatinib (LOXO-292) pralsetinib (BLU-667), have been approved treating RET-alteration-positive However, achieving complete response with inhibitor remains challenge in most patients. In cell cultures, these inhibitors increase the expression of CCDC6-RET fusion protein, which may affect their effectiveness...
Abstract Lipopolysaccharide (LPS)‐induced sepsis‐associated acute kidney injury (SA‐AKI) is a model of clinical serious care syndrome, with high morbidity and mortality. Tacrolimus (TAC), novel immunosuppressant that inhibits inflammatory response, plays pivotal role in diseases. In this study, LPS treated mice cultured podocytes were used as the models SA‐AKI vivo vitro , respectively. Medium‐ high‐dose TAC administration significantly attenuated renal function pathological manifestations...
Tumor microenvironment (TME) is a complex and integrated system containing variety of tumor-infiltrating immune cells stromal cells.They are closely connected with cancer influence the development progression cancer.Traditional Chinese medicine (TCM) an important complementary therapy for treatment in China.It mainly eliminates by regulating TME.The aim this review to systematically summarize crosstalk between tumor TME, research progress TCM great significance revealing therapeutic...
Anorexia is a major cause of cancer cachexia and induced by growth differentiation factor-15 (GDF15), which activates the rearranged during transfection (RET) protein tyrosine kinase in hindbrain through GDF family receptor α-like (GFRAL), raising possibility targeting RET for treatment. RET-altered patients treated with RET-selective inhibitors gain weight, however, it unclear whether this results from tumor regression that improves overall health patients. Thus, potential using inhibitor...
Selpercatinib (LOXO292) and pralsetinib (BLU667) are RET protein tyrosine kinase inhibitors (TKIs) recently approved for treating RET-altered cancers. However, mutations that confer selpercatinib/pralsetinib resistance have been identified, necessitating development of next-generation TKIs. While acquired G810C/R/S/V were reported in selpercatinib-treated patients, it was unclear whether all these other potential G810 mutants resistant to selpercatinib pralsetinib. Here, we profiled on six...
Background: Colorectal cancer (CRC) with the Raf murine sarcoma viral oncogene homolog B (BRAF) V600E had a relatively poor prognosis. Anaplastic lymphoma kinase (ALK) fusion and mesenchymal-to-epithelial transition factor (MET) amplification have been recognized as potentially important therapeutic targets in non-small cell lung (NSCLC). However, both of them are extremely lower frequencies (<2%) metastatic CRC, few studies mentioned real application their inhibitors CRC treatment. Case...
Diabetic nephropathy (DN) is one of the most common microvascular complications associated with diabetes mellitus (DM); incidence has been predicted to reach 7.7% by 2030 on a global scale. Krüppel‑like factor 5 (KLF5) involved in numerous important biological processes; however, potential effects KLF5 podocytes patients diabetic nephrotic have not yet investigated. In present study, synaptopodin expression was investigated using an immunofluorescence assay. Following this, proliferation MTT...
This study investigated the factors influencing survival time of patients with lung-cancer-associated hypercalcemia.A total 64 pathologically confirmed Stage IV hypercalcemia were enrolled from Beijing Hospitals between August 2010 and July 2015. Clinical materials included patients' gender, age, pathological type, highest albumin-corrected calcium level, serum alkaline phosphatase creatinine clearance rate, organ (bone, liver, brain, adrenal gland) metastasis, number distal metastatic...
To investigate effects of mandibular advancement device (MAD) therapy for obstructive sleep apnoea hypopnea syndrome (OSAHS) on the genioglossus contractile properties and fibre-type distribution. Thirty 6-month old male New Zealand white rabbits were randomised into three groups: OSAHS, MAD, controls. Rabbits in Group OSAHS MAD established as models by injection, at a dose 2ml hydrophilic polyacrylamide gel, via submucous muscular layer soft palate. Spiral computed tomography (CT) showed...
Recently, a novel heterozygous missense mutation c.T1421G (p. L474R) in the PODXL gene encoding podocalyxin was identified an autosomal dominant focal segmental glomerulosclerosis (AD-FSGS) pedigree. However, this appeared not to impair function, and it is necessary identify new mutations determine their causative role for FSGS. In present study, we report identification of nonsense (c.C976T; p. Arg326X) Chinese pedigree featured by proteinuria renal insufficiency with AD inheritance whole...
A novel unsymmetrical 1,3,4-oxadiazole derivative (2-POXD-B8) was synthesized. 2-POXD-B8 can form organogel in methanol. The gelation and self-assembly behavior of were researched by SEM, XRD, UV–vis, temperature-dependent FT-IR, etc. π–π interaction van der Waals force are viewed as the main driving forces process. In addition, showed acid-responsive properties different states, including gel state film state. dual-channel acid response reversible solution–gel transition fluorescence...