Slobodan Klašnja

ORCID: 0000-0002-6040-0183
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About
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Research Areas
  • COVID-19 Clinical Research Studies
  • Long-Term Effects of COVID-19
  • Cardiovascular Disease and Adiposity
  • SARS-CoV-2 and COVID-19 Research
  • Cardiac Imaging and Diagnostics
  • Liver Disease Diagnosis and Treatment
  • Cardiovascular Function and Risk Factors
  • COVID-19 and healthcare impacts
  • Obstructive Sleep Apnea Research
  • Pericarditis and Cardiac Tamponade
  • Venous Thromboembolism Diagnosis and Management
  • Adipokines, Inflammation, and Metabolic Diseases
  • Advanced MRI Techniques and Applications
  • Ultrasound in Clinical Applications
  • Diet, Metabolism, and Disease
  • Alcohol Consumption and Health Effects
  • Regulation of Appetite and Obesity
  • Appendicitis Diagnosis and Management
  • Intensive Care Unit Cognitive Disorders
  • Apelin-related biomedical research
  • Trypanosoma species research and implications
  • Blood Pressure and Hypertension Studies
  • Healthcare Systems and Public Health
  • Fatty Acid Research and Health
  • Diamond and Carbon-based Materials Research

University Hospital Medical Center Bezanijska kosa
2015-2024

University of Belgrade
2015-2022

Kliničko Bolnički Centar Zvezdara
2021-2022

Society of Critical Care Medicine
2021

Introduction . Mortality among critically ill COVID‐19 patients remains relatively high despite different potential therapeutic modalities being introduced recently. The treatment of is a challenging task, without identified credible predictors mortality. Methods We performed an analysis 160 consecutive with confirmed infection admitted to the Respiratory Intensive Care Unit between June 23, 2020, and October 2, in University Hospital Center Bezanijska kosa, Belgrade, Serbia. Patients on...

10.1155/2021/6648199 article EN cc-by Oxidative Medicine and Cellular Longevity 2021-01-01

Introduction: Obstructive sleep apnea (OSA) is a serious condition linked with various metabolic disorders and associated increased all-cause cardiovascular mortality. Although the potential mechanisms of pathophysiological processes related to OSA are relatively well known, data regarding correlation between obstructive apnea, dyslipidemia, systemic inflammation still inconclusive. Methods: The study was conducted as retrospective cohort including 328 patients newly diagnosed during period...

10.3389/fphar.2022.897279 article EN cc-by Frontiers in Pharmacology 2022-05-25

Introduction: The present study aimed to establish the role of lipid abnormalities and inflammatory markers for developing cardiovascular risk, as well address importance obesity a common comorbidity in patients with obstructive sleep apnea (OSA). Methods: was conducted prospective cohort including 120 newly diagnosed OSA between 2019 2020, at University Clinical Hospital Center "Bezanijska kosa", Belgrade, Serbia. diagnosis established by polysomnography. In all patients, sociodemographic...

10.3389/fphar.2022.898072 article EN cc-by Frontiers in Pharmacology 2022-06-15

Coronary microvascular dysfunction (CMD) is a clinical entity linked with various risk factors that significantly affect cardiac morbidity and mortality. Hypertension, one of the most important, causes both functional structural alterations in microvasculature, promoting occurrence progression angina. Endothelial capillary rarefaction play significant role development CMD among patients hypertension. also related to several hypertension-induced morphological changes myocardium subclinical...

10.3390/medicina59122149 article EN cc-by Medicina 2023-12-11

Introduction . Risk stratification is an important aspect of COVID‐19 management, especially in patients admitted to ICU as it can provide more useful consumption health resources, well prioritize critical care services situations overwhelming number patients. Materials and Methods A multivariable predictive model for mortality was developed using data solely from a derivation cohort 160 with moderate severe ARDS ICU. The regression coefficients the final multivariate study were used assign...

10.1155/2021/6654388 article EN cc-by Oxidative Medicine and Cellular Longevity 2021-01-01

Acute coronary syndrome (ACS) in patients with COVID-19 is triggered by various mechanisms and can significantly affect the patient’s further treatment prognosis. The study aimed to investigate characteristics, major complications, predictors of mortality ACS. All consecutive hospitalized from 5 July 2020 May 2021 for ACS confirmed SARS-Co-2 were prospectively enrolled tracked until June 2021. Data electronic records age diagnosis, matched non-COVID-19 group, extracted compared. Overall, 83...

10.3390/jcm11071791 article EN Journal of Clinical Medicine 2022-03-24

This study aimed to calculate the frequency of elevated liver enzymes in hospitalized patients with coronavirus disease 2019 (COVID-19) infection and test if enzyme biochemistry levels on admission could predict computed tomography (CT) scan severity score bilateral interstitial pneumonia.This single-center comprised 323 including their demographic data, laboratory analyses, radiological findings. All information was taken from electronic health records, followed by statistical analysis.Out...

10.3390/medicina58070842 article EN cc-by Medicina 2022-06-23

Healthcare workers (HCWs) are at higher risk of developing COVID-19 due to their professional exposition the SARS-CoV-2 virus. This study assesses intention vaccination against before vaccines were approved, and rate vaccine uptake during first nine months immunization among HCWs. A cross-sectional seroprevalence was carried out July 2020 in University Clinical Hospital Center Bezanijska Kosa Belgrade, Serbia that included 62.8% all Besides serological testing for IgG antibodies, data about...

10.3390/vaccines10040500 article EN cc-by Vaccines 2022-03-24

Thrombotic complications, such as pulmonary embolism, are common in COVID-19 patients. Point-of-care ultrasound is a highly recommended tool for orientation critically ill patients with suspected or confirmed complications. An observational study was conducted on 32 consecutive embolism and infection treated the Intensive Care Unit of University Hospital Medical Center "Bežanijska kosa", Belgrade, Serbia, between April 2021 March 2022. Predictors need oxygen support were determined, while...

10.3390/diagnostics12102380 article EN cc-by Diagnostics 2022-09-30

Introduction. There are still no definite curative or preventive strategies for COVID-19 disease. It is crucial to fully comprehend the pathogenesis of infection so that we can develop expedient pharmacological protocols. While impact cytokine storm on severity has been one most tested hypotheses, role bradykinin and various other oxidative stress markers relatively under-researched. Their levels be determined immediately after a hospital admission they could used as early predictors further...

10.1155/2022/7920915 article EN Oxidative Medicine and Cellular Longevity 2022-10-27

Coronary microvascular dysfunction (CMD) is a clinical entity linked with various risk factors that significantly affect cardiac morbidity and mortality. Hypertension, one of the most important, causes both functional structural alterations in microvasculature, promoting occurrence progression angina. Endothelial capillary rarefaction play significant role development CMD among patients hypertension. also related to several hypertension-related morphological changes myocardium subclinical...

10.20944/preprints202311.1143.v1 preprint EN 2023-11-17

Objective: Left ventricular hypertrophy (LVH) is a structural remodeling of the heart developing as response to volume and/or pressure overload. Previous studies have shown that in patients with long duration hypertension, hypertension not an independent factor development LVH and occurrence does depend on length severity but role played by other comorbidities such triglycerides, age, gender, genetics, insulin resistance, obesity, physical inactivity, increased salt intake chronic stress. To...

10.1097/01.hjh.0000467824.01917.f5 article EN Journal of Hypertension 2015-06-01

Background: In the post-COVID-19 era, there is growing concern regarding its impact on cardiovascular health and following effects overall quality of life affected individuals. This research seeks to investigate cardiac magnetic resonance (CMR) findings COVID-19 their Methods: An observational, cross-sectional study was conducted in consecutive patients with persistent symptoms after who were referred CMR due suspected myocardial injury. addition, completed a questionnaire about during...

10.3390/diagnostics14171937 article EN cc-by Diagnostics 2024-09-02

The clinical efficacy of chemotherapy, as a recognized therapeutic approach for malignant diseases, usually has certain limitations due to its cardiotoxicity (CT) and consequent cardiomyopathy, or even heart failure. CT is defined any cardiac injury connected with oncology treatment, whether it chemo-, radio-, targeted immunotherapy, cancer by itself, represents great challenge clinicians in everyday practice. A wide spectrum factors related chemotherapy (type drug, dose during each cycle,...

10.5937/arhfarm73-40534 article EN cc-by-sa Arhiv za farmaciju 2023-01-01

It has been a year and half since the fight against COVID-19 pandemic started. In today's protocols for treatment of prevention its complications, corticosteroid therapy anticoagulant have crucial part. The goal this article is to show, based on available data, both benefits disadvantages in treating infection caused by Sars-CoV-2 virus. At very onset pandemic, an increased frequency thrombotic events negatively impacting course outcome disease, was registered. observed that values D-dimer...

10.5937/smclk3-35014 article EN Srpski medicinski casopis Lekarske komore 2022-01-01

At the end of December 2019, a certain number patients with pneumonia unknown etiology appeared in Chinese city Wuhan. The etiological agent corona virus disease (COVID-19) was identified as from Coronaviridae family called Novel Coronavirus, or SARS-CoV-2 (Severe Acute Respiratory Coronavirus 2). COVID-19 took on proportions pandemic. Therapeutic options for include antiviral, anticoagulant, corticosteroid, biological, antibiotic, multivitamin, symptomatic therapy, and oxygen support....

10.5937/sjait2106085m article EN cc-by Serbian Journal of Anesthesia and Intensive Therapy 2021-01-01

Abstract Still, there are no curative or preventive strategies for COVID-19, noting the importance of understanding pathogenesis COVID-19 infections rational development pharmacological protocols. Considering proinflammatory, oxidative and other roles BK Galectin-3, it is more than relevant to investigate clinical repercussion that molecules in patients who survived died after confirmed pneumonia. This was prospective cross-sectional study which included 47 adult with SARS-CoV-2 infection...

10.21203/rs.3.rs-1662049/v1 preprint EN cc-by Research Square (Research Square) 2022-05-19
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