A5023043258- Vitamin K Research Studies
- Amino Acid Enzymes and Metabolism
- Biochemical Acid Research Studies
- melanin and skin pigmentation
- Antimicrobial Peptides and Activities
- Sulfur Compounds in Biology
- 14-3-3 protein interactions
- Metabolism and Genetic Disorders
- Blood disorders and treatments
- RNA Interference and Gene Delivery
- Viral Infectious Diseases and Gene Expression in Insects
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Biomedical Ethics and Regulation
- Nitric Oxide and Endothelin Effects
- Lignin and Wood Chemistry
- Enzyme Production and Characterization
- Biofuel production and bioconversion
- Insect Resistance and Genetics
- Antibiotics Pharmacokinetics and Efficacy
- Polyamine Metabolism and Applications
- Neutropenia and Cancer Infections
- Protein Hydrolysis and Bioactive Peptides
- Research on Leishmaniasis Studies
- Chronic Lymphocytic Leukemia Research
Université catholique de lyon
2023-2024
UR CONFLUENCE: Sciences et Humanités
2023-2024
St. Jude Children's Research Hospital
2024
Université Claude Bernard Lyon 1
2024
University of California, Los Angeles
2021
Université Bourgogne Franche-Comté
2016-2020
Agents infectieux, résistance et chimiothérapie
2018-2019
Université de Picardie Jules Verne
2018-2019
Université de Limoges
2018
Université de franche-comté
2014
Polyphenols are plant secondary metabolites which possess many positive effects on human health. Although these beneficial could be mediated through an increase in nitric oxide synthase activity, little is known regarding the inhibitory effect of polyphenols mammal arginase, enzyme competes with for their common substrate, L-arginine. The aim present study was to determine potential a series as mammalian arginase inhibitors and identify some structure-activity relationships. For this...
Journal Article Trypsin and Elastase Inhibitors from Bitter Gourd (Momordica charantia LINN.) Seeds: Purification, Amino Acid Sequences, Inhibitory Activities of Four New Get access Nobuaki Hamato, Hamato *Department Chemistry Materials Technology, Faculty Engineering Design, Kyoto Institute TechnologyMatsugasaki, Sahyo-ku, 606 Search for other works by this author on: Oxford Academic PubMed Google Scholar Takashi Koshiba, Koshiba Thien-Ngoc Pham, Pham Yoko Tatsumi, Tatsumi Daisaku Nakamura,...
Arginases are enzymes that involved in many human diseases and have been targeted for new treatments. Here a series of cinnamides was designed, synthesized evaluated vitro silico their inhibitory activity against mammalian arginase. Using microassay on purified liver bovine arginase (b-ARG I), (
Caffeic acid and related natural compounds were previously described as Leishmania amazonensis arginase (L-ARG) inhibitors, against the whole parasite in vitro. In this study, we tested cinnamides that synthesized to target human arginase. The compound caffeic phenethyl amide (CAPA), a weak inhibitor of (IC50 = 60.3 ± 7.8 μM) was found have 9-fold more potency L-ARG 6.9 0.7 μM). other did not inhibit characterized L-ARG, showing an IC50 between 1.3–17.8 μM, where most active 15 1.3 0.1 All...
The positions of the reactive site and disulfide bridges in fungal protease inhibitor F (FPI-F) from silkworm (Bombyx mori), which has a unique amino acid sequence inhibitory specificity, were investigated. At pH 3.0, subtilisin BPN', is one target proteases this inhibitor, specifically cleaved peptide bond at Thr(29)-Val(30). was regenerated by BPN' 8.0. These results indicate that Thr(29)-Val(30) site. locations determined to be Cys(3)-Cys(35), Cys(14)-Cys(27), Cys(18)-Cys(55),...
Interest in arginase, metalloenzyme hydrolyzing L-arginine into L-ornithine and urea, was stimulated by the finding that arginases might compete with nitric oxide synthases for their common substrate, therefore regulate NO availability. Thus, emerged concept selective arginase inhibitors be a valuable strategy treatment of various diseases associated to decreased [1,2]. Therefore, research new candidates targeting on has been attracting scientists but methods used, terms models biochemical...
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease. Our medicinal chemistry strategy relied on the design new compounds using ring contraction/isosteric replacement constrained analogy DYRK1A inhibitors, thus resulting in inhibitory activity enhancement. Whereas good effect targeted observed 5-hydroxy 4i-k (IC
Abstract Corresponding author: Thanh Pham, 262 Danny Thomas Pl, Memphis, TN 38105, thanh.pham@stjude.org, 503-380-8576 Alternate corresponding Shane Cross, shane.cross@stjude.org, 901-595-3300 The authors have no conflicts of interest to declare. Background Children receiving chemotherapy or hematopoietic cell transplantation (HCT) are at high risk for life-threatening antibiotic-resistant bacterial infections. Patients who present with febrile neutropenia (FN) following a recent resistant...
The interest to consider arginase, a metalloenzyme hydrolysing L-arginine L-ornithine and urea, as therapeutic target has grown in the recent years use of arginase inhibitors been proved be beneficial cardiovascular nervous system diseases [1]. However, most potent commercial cannot used clinic due their pharmacokinetic toxicological properties [2]. Search for new is thus required such compounds may inspired by natural substances [3]. Further screening series polyphenols on an inhibitory...