A5011451182- Nitric Oxide and Endothelin Effects
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Nerve injury and regeneration
- Autoimmune and Inflammatory Disorders Research
- Renin-Angiotensin System Studies
- Exercise and Physiological Responses
- Receptor Mechanisms and Signaling
- Atherosclerosis and Cardiovascular Diseases
- Cytokine Signaling Pathways and Interactions
- Neuroscience and Neuropharmacology Research
- Amino Acid Enzymes and Metabolism
- Pharmacological Effects of Natural Compounds
- Apelin-related biomedical research
- Phytochemistry and Biological Activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone and Joint Diseases
- Metabolism and Genetic Disorders
- Fatty Acid Research and Health
- Neurogenesis and neuroplasticity mechanisms
- Vitamin K Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Inserm
2013-2024
Université de franche-comté
2014-2024
Centre Hospitalier Universitaire de Besançon
2024
Interactions Hôte-Greffon-Tumeur & Ingénierie Cellulaire et Génique
2024
Université Bourgogne Franche-Comté
2016-2022
Université de Bourgogne
2002-2021
Innovation Plasturgie Composites
2020
Pathophysiology, Diagnosis and Treatment of Bone Diseases
2012-2018
Hôpital Européen Georges-Pompidou
2017
Cognition, Action, and Sensorimotor Plasticity
2016
To evaluate the contribution of cellular dysfunction and neuronal loss to brain N‐ acetylaspartate (NAA) depletion, NAA was measured in tissue by HPLC UV detection rats subjected cerebral injury, associated or not with cell death. When lesion induced intracarotid injection microspheres, fall related degree embolization severity oedema. striatal local malonate, larger volume, higher depletion. However, reduction oedema treatment lipophilic iron chelator dipyridyl (20 mg/kg, 1 h before every 8...
A decrease in nitric oxide (NO) bioavailability has been proposed to contribute endothelial dysfunction and increased peripheral resistances during essential arterial hypertension. Given that arginine is a substrate for both arginase NO synthase, activity may be critical factor bioavailability. To test this hypothesis, we evaluated the effects of inhibitor alpha-difluoromethylornithine (DFMO) spontaneously hypertensive rats (SHR).Vascular reactivity experiments were performed on thoracic...
Growing evidence suggests that arginase misregulation plays a key role in the pathophysiology of essential hypertension. In present study, we investigated potential cardiovascular therapeutic effects long-term treatment with an inhibitor adult spontaneously hypertensive rats (SHR) fully developed Treatment 25-week-old SHR Nω-hydroxy-nor-l-arginine (nor-NOHA, 40 mg/day for 10 weeks) sustainably reduced systolic blood pressure (−30 mmHg, P < 0.05). The antihypertensive effect nor-NOHA was...
Changes in circulating brain-derived neurotrophic factor (BDNF) levels were reported patients with or at risk for cardiovascular diseases associated endothelial dysfunction, suggesting a link between BDNF and functionality. However, little is known on BDNF. Our aim was to investigate levels/localization, function, relevance of (western blotting) localization (immunostaining) assessed the heart aorta from rats impaired (spontaneously hypertensive [SHR]), normal (Wistar Kyoto [WKY]), improved...
The anti-atherogenic effects of omega 3 fatty acids, namely eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) are well recognized but the impact dietary intake on bioactive lipid mediator profiles remains unclear. Such a profiling effort may offer novel targets for future studies into mechanism action acids. present study aimed to determine DHA supplementation polyunsaturated (PUFA) oxygenated metabolites investigate their contribution atherosclerosis prevention. A special emphasis was...
High vascular arginase activity and subsequent reduction in nitric oxide production were recently reported animal models of hypertension. The present study investigated the effects in-vivo inhibition on blood pressure function adult spontaneously hypertensive rats.Ten-week-old rats normotensive age-matched Wistar-Kyoto treated with or without selective inhibitor N-hydroxy-nor-L-arginine for 3 weeks (10 40 mg/kg per day, intraperitoneally). Systolic cardiac rate measured before during...
Effects of different inulin-type fructan fractions were studied on atherosclerotic plaque formation in male apo E-deficient mice. Thirty-two mice randomly divided into four groups and received either a semi-purified sucrose-based diet (control group), or diets which sucrose was replaced part by various fructans (10 g/100 g): long-chain inulin, oligofructose, an oligofructose-enriched inulin for 16 weeks. The presence plaques assessed histomorphometry the aortic sinus. fed had about 35 % 25...
Physical exercise constitutes an innovative strategy to treat deficits associated with stroke through the promotion of BDNF-dependent neuroplasticity. However, there is no consensus on optimal intensity/duration exercise. In addition, whether previous changes effect brain not known. Therefore, present study compared effects a clinically-relevant form cerebral BDNF levels and localization in control versus rats. For this purpose, treadmill (0.3 m/s, 30 min/day, for 7 consecutive days) was...
Because arginase and nitric oxide (NO) synthases (NOS) compete to degrade l-arginine, plays a crucial role in the modulation of NO production. Moreover, 1 isoform is marker M2 phenotype macrophages that play key tissue remodeling resolution inflammation. While has been extensively investigated ischemic stroke, effect stroke on pathway unknown. The present study focuses expression/activity localization before after (1, 8, 15 30 days) photothrombotic model. This model results cortical lesion...
Evidence that brain-derived neurotrophic factor (BDNF), a neurotrophin largely involved in cognition, is expressed by cerebral endothelial cells led us to explore rats the contribution of microvasculature BDNF found brain tissue and link between cerebrovascular nitric oxide (NO) production.Brain protein levels were measured before after situ removal endothelium was achieved perfusion with 0.2% CHAPS (3-[(3-cholamidopropyl) dimethylammonio]-1-propane sulphonate) solution. mRNA as well NO...
Polyphenols are plant secondary metabolites which possess many positive effects on human health. Although these beneficial could be mediated through an increase in nitric oxide synthase activity, little is known regarding the inhibitory effect of polyphenols mammal arginase, enzyme competes with for their common substrate, L-arginine. The aim present study was to determine potential a series as mammalian arginase inhibitors and identify some structure-activity relationships. For this...
Objectives To determine mechanisms involved in endothelial dysfunction (ED) during the course of arthritis and to investigate link between cytokines, chemokines osteoprotegerin. Approach Results Experiments were conducted on aortic rings at day 4 (preclinical), 11 (onset disease), 33 (acute disease) 90 (chronic after adjuvant-induced (AIA) Lewis rats. At 4, unique vascular abnormality was a reduced norepinephrine-induced constriction. 11, function assessed by relaxation acetylcholine normal...
New tritarget small molecules combining Ca2+ channels blockade, cholinesterase, and H3 receptor inhibition were obtained by multicomponent synthesis. Compound 3p has been identified as a very promising lead, showing good blockade activity (IC50 = 21 ± 1 μM), potent affinity against hH3R (Ki 565 62 nM), moderate but selective hBuChE 7.83 0.10 strong antioxidant power (3.6 TE), ability to restore cognitive impairment induced lipopolysaccharide.