A5053615453- Malaria Research and Control
- RNA regulation and disease
- RNA modifications and cancer
- Invertebrate Immune Response Mechanisms
- Mosquito-borne diseases and control
- Complement system in diseases
- Amyotrophic Lateral Sclerosis Research
- Aquaculture disease management and microbiota
- Prion Diseases and Protein Misfolding
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Glycosylation and Glycoproteins Research
- RNA and protein synthesis mechanisms
- HIV Research and Treatment
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Animal Genetics and Reproduction
- Biochemical Analysis and Sensing Techniques
- MicroRNA in disease regulation
- Neurogenetic and Muscular Disorders Research
- Connective tissue disorders research
- Monoclonal and Polyclonal Antibodies Research
- Craniofacial Disorders and Treatments
- Cholinesterase and Neurodegenerative Diseases
Amsterdam UMC Location Vrije Universiteit Amsterdam
2011-2021
University of Groningen
2015
Amsterdam Neuroscience
2015
Biomedical Primate Research Centre
2000-2003
Leiden University
1993-1997
Short stature caused by point mutations or deletions of the short homeobox (SHOX) gene (SHOX haploinsufficiency (SHI)) is a registered indication for GH treatment. Patients with SHOX enhancer deletion (SED) have similar phenotype, but their response to unknown. It uncertain if duplications its (SDUP) cause stature. This study aimed describe clinical characteristics and growth treatment in patients aberrations enhancers.In this retrospective multi-center (2002-March 2014) information was...
Malaria parasites (Plasmodium spp.) differentially express structurally distinct sets of rRNA genes in a stage-specific manner. The four the rodent malaria parasite, P. berghei, form two classes 2 units that are genetically unlinked and termed A-type S-type. Through Northern analysis situ hybridization, expression was demonstrated synchronized parasite preparations covering developmental pathway from initiation blood-stage asexual cycle to production mature ookinetes. were transcribed direct...
Abstract Carpenter syndrome (acrocephalopolysyndactyly type II) is a rare autosomal recessive disorder. It was clinically diagnosed in female baby with polysyndactyly and craniosynostosis referral clinic Northern Tanzania. In the RAB23 gene, previously described homozygous variant c.82C>T p.(Arg28*) detected that results premature stop codon. Both parents were demonstrated to be heterozygous carriers of this variant. Herewith, its pathogenicity proved. A literature search suggests first...
Transgenic pathogenic microorganisms expressing host cytokines such as gamma interferon (IFN-gamma) have been shown to manipulate host-pathogen interaction, leading immunomodulation and enhanced protection. Expression of in malaria parasites offers the opportunity investigate potential an immunomodulatory approach by generating immunopotentiated parasites. Using primate parasite Plasmodium knowlesi, we explored conditions for P. knowlesi transfected with DNA constructs rhesus monkey (Macaca...
We demonstrate that the 1C10 monoclonal antibody (mAb) directed against N-terminal domain of colicin A recognizes a 13 residue-region (13Thr-Gly-Trp-Ser-Ser-Glu-Arg-Gly-Ser-Gly-Pro-Asp-Pro25). When this peptide is inserted into protein in amino-terminal or an internal position, tagged efficiently detected by 1C11 mAb either immunoblotting immunoprecipitation. In vitro, minimal structure required for detection using pepscan system 19Arg-Gly-Ser-Gly-Pro-Glu-Pro25, indicating vivo proper...
Aotus monkeys offer one of the few models that can be used for evaluation immunogenicity and efficacy new vaccine candidates against human malarias, Plasmodium falciparum vivax . However, tools available immune responses in these New World primates are still limited. In present study, a previously selected set monoclonal antibodies were raised T cell determinants reactive with at least other primate species was investigated its reactivity lymphocytes using FACS analysis, indirect...
CSF N-acetylaspartylglutamate (NAAG) has been found to be elevated in some hypomyelinating disorders. This study addressed the question whether it could used as a marker for hypomyelination and means distinguish between disorders biochemically. We have measured NAAG cohort of 28 patients with known unknown aetiology. was 7 patients, but normal majority, including defined is not universal hypomyelination, mechanism its elevation remains poorly understood.