A5100681761- Cancer therapeutics and mechanisms
- DNA Repair Mechanisms
- Bioactive Compounds and Antitumor Agents
- Lung Cancer Research Studies
- DNA and Nucleic Acid Chemistry
- Genetic Neurodegenerative Diseases
- Neutropenia and Cancer Infections
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- HIV/AIDS drug development and treatment
- Neurological disorders and treatments
- Insect Pest Control Strategies
- Animal Nutrition and Physiology
- Plant Genetic and Mutation Studies
- Adipose Tissue and Metabolism
- 14-3-3 protein interactions
- Cancer Genomics and Diagnostics
- Insect-Plant Interactions and Control
- PARP inhibition in cancer therapy
- Plant tissue culture and regeneration
- Forest Insect Ecology and Management
- CRISPR and Genetic Engineering
- Silkworms and Sericulture Research
- Muscle metabolism and nutrition
- Microtubule and mitosis dynamics
Jinan University
2024-2025
Beijing Jiaotong University
2024
Jiujiang University
2024
Shanghai Xuhui Central Hospital
2016-2020
East Carolina University
2016-2020
Shanghai Institute of Nutrition and Health
2020
Shanghai Clinical Research Center
2020
Roswell Park Comprehensive Cancer Center
2000-2002
National Cancer Institute
1999
National Institutes of Health
1999
Topoisomerase I (TOP1)-mediated DNA damage induced by camptothecin (CPT) in the presence of active transcription has been studied using purified calf thymus TOP1 and T7 RNA polymerase. CPT-stabilized cleavable complexes located on template strand within transcribed region were found to be converted into irreversible breaks elongating By contrast, non-template was unaffected Previous studies have demonstrated that polymerase is arrested but not [Bendixen et al ., (1990) Biochemistry , 29,...
Camptothecins demonstrate a broad spectrum of antitumor activity. Although they are known to trap DNA topoisomerase I on DNA, form cleavable complexes, and generate breaks upon collision with or RNA polymerases, the precise mechanisms predictive for activity remain be identified. Recent studies using panels colorectal breast cancer cell lines indicate that events downstream complexes more relevant. In this study, we chose SN-38, an active metabolite irinotecan, characterize double strand...
We have proposed that the low-fidelity compensatory backup alternative DNA repair pathways drive multistep carcinogenesis. Here, we apply it to interpret clinical features of cancer, such as mutator phenotype, tissue specificity, age diverse types cancers originated from same type tissue, cancer susceptibility patients with repair-defective syndromes, development only for a selected number individuals among those share genetic defect, invasion and metastasis. Clinically, theory predicts...
Human head and neck squamous carcinoma cell lines, A253 FaDu, were utilized to identify mediators associated with response topoisomerase I poison, SN-38, a metabolite of irinotecan. The drug sensitivity FaDu cells SN-38 was significantly higher than that the cells. In cells, G2/M arrest following treatment (0.35 microM 2-h exposure) accompanied by DNA fragmentation in 50-300 kb range, but accumulated S-phase concurrently induction smaller 4-80 range. Because critical regulatory step...
The Camellia weevil,
Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by motor dysfunction and cognitive decline. While retinal abnormalities have been documented in some HD patients animal models, the nature of these abnormalities—specifically whether they originate inner or outer retina—remains unclear, particularly regarding their progression with age. This study investigates structure function transgenic mice (R6/1) compared to C57BL/6 J control at 2, 4, 6 months age,...
Abstract TOP2-poisoning bioflavonoids and pesticides are linked to the copy number variation-related autism chromosome translocation-related leukemia. On other hand, poisoned DNA topoisomerase II (TOP2) can lead aberration. However, except a limited of genes such as MLL fusion, TOP2-targeted genes, well their relationships with any specific diseases, not defined. We applied γH2A.X antibodies genome-widely immunoprecipitate chromatins that were associated repair TOP2 poison etoposide-induced...