A5087985727- Mass Spectrometry Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Medical Imaging Techniques and Applications
- Drug Transport and Resistance Mechanisms
- Epilepsy research and treatment
- Analytical chemistry methods development
- Peroxisome Proliferator-Activated Receptors
- Nuclear Physics and Applications
- Lung Cancer Treatments and Mutations
- Pharmacological Effects and Toxicity Studies
- Analytical Chemistry and Chromatography
- X-ray Spectroscopy and Fluorescence Analysis
- Radiopharmaceutical Chemistry and Applications
- Ion-surface interactions and analysis
- Glioma Diagnosis and Treatment
- Advanced Chemical Physics Studies
- Advanced Proteomics Techniques and Applications
- Photopolymerization techniques and applications
- interferon and immune responses
- Adsorption, diffusion, and thermodynamic properties of materials
- Neurotransmitter Receptor Influence on Behavior
- Molecular Biology Techniques and Applications
- Diet and metabolism studies
University of Manchester
2012-2024
Université de Tours
2024
Manchester Academic Health Science Centre
2009-2020
Engineering and Physical Sciences Research Council
2016-2018
Cancer Research UK Manchester Institute
2013
Manchester Metropolitan University
1997-2011
Eli Lilly (United States)
2009
The Christie NHS Foundation Trust
2009
Ricardo AEA (United Kingdom)
1991-1994
Wolfson Foundation
1990
An extremely well-preserved dinosaur ( Cf. Edmontosaurus sp.) found in the Hell Creek Formation (Upper Cretaceous, North Dakota) retains soft-tissue replacement structures and associated organic compounds. Mineral cements precipitated skin apparently follow original cell boundaries, partially preserving epidermis microstructure. Infrared electron microprobe images of ossified tendon clearly show preserved mineral zonation, with silica trapped carbon dioxide forming thin linings on Haversian...
In Brief The experience of pain in humans is modulated by endogenous opioids, but it largely unknown how the opioid system adapts to chronic states. Animal models point upregulation receptors (OpR) brain, with functional significance. We sought evidence for a similar relationship between and OpR availability humans. Using positron emission tomography radiotracer 11C-diprenorphine, patients arthritis (n = 17) healthy controls 9) underwent whole-brain scanning calculate parametric maps...
Mixed leukocyte (white blood cells [WBCs]) trafficking using positron emission tomography (PET) is receiving growing interest to diagnose and monitor inflammatory conditions. PET, a high sensitivity molecular imaging technique, allows precise quantification of the signal produced from radiolabelled moieties. We have evaluated new method for radiolabelling WBCs with either zirconium‐89 ( 89 Zr) or copper‐64 64 Cu) PET imaging. Chitosan nanoparticles (CNs) were by process ionotropic gelation...
Abstract Alterations in lipid metabolism cancer cells impact cell structure, signaling, and energy metabolism, making a potential diagnostic marker therapeutic target. In this study, we combined PET, desorption electrospray ionization-mass spectrometry (DESI-MS), nonimaging MS, transcriptomic analyses to interrogate changes transgenic zebrafish model of oncogenic RAS-driven melanocyte neoplasia progression. Exogenous fatty acid uptake was detected melanoma tumor nodules by PET using the...
Metastasis is the leading cause of cancer-related death. This multistage process involves contribution from both tumour cells and stroma to release metastatic into circulation. Circulating (CTCs) survive circulatory cytotoxicity, extravasate colonise secondary sites effecting outcome. Reprogramming transcriptomic landscape a hallmark, but detecting underlying master regulators that drive pathological gene expression key challenge, especially in childhood cancer. Here we used whole plus...
Abstract Desorption electrospray ionisation mass spectrometry (DESI-MS) can image hundreds of molecules in a 2D tissue section, making it an ideal tool for mapping tumour heterogeneity. Tumour lipid metabolism has gained increasing attention over the past decade; and here, heterogeneity been visualised glioblastoma xenograft using 3D DESI-MS imaging. The use automatic slide loader automates imaging high sample-throughput. Glioblastomas are highly aggressive primary brain tumours, which...
Abstract Objective Overexpression of the drug transporter P‐glycoprotein (P‐gp) is thought to be involved in drug‐resistance epilepsy by extrusion antiepileptic drugs (AEDs). We used positron emission tomography (PET) and P‐gp substrate radiotracer (R)‐[ 11 C]verapamil (VPM) together with third‐generation inhibitor tariquidar (TQD) evaluate function individuals drug‐resistant epileptogenic developmental lesions. Methods Twelve healthy controls (7 male, median age 45, range 35‐55 years), two...
Abstract There are four neutralization‐reionization processes which can be studied. In the first two, gaseous cations collisionally reduced and resulting fast neutrals either oxidized by collisional electron removal (NR) or further attachment (NR − ). third fourth processes, anions ( NR) NR These illustrated briefly using interrelated species [SF 5 ] + . Negative‐ion‐negative‐ion ) for [CH 3 O] , [C 2 H [CO [HCO compared with processes. addition, ionization of formed in unimolecular...
Positron emission tomography (PET) and fluorescence labelling have been used to assess the pharmacokinetics, biodistribution eventual fate of a hydrogel‐forming nonapeptide, FEFKFEFKK (F9), in healthy mice, using 18 F‐labelled fluorescein isothiocyanate (FITC)‐labelled F9 analogues. was site‐specifically radiolabelled with 2‐[ F]fluoro‐3‐pyridinecarboxaldehyde ([ F]FPCA) via oxime bond formation. [ F]FPCA‐F9 vivo evaluated both as solution, following intravenous administration, hydrogel when...
Sputter-initiated resonance ionization spectroscopy (SIRIS) is an analytical technique with extremely high sensitivity, selectivity, dynamic range, and quantitation accuracy. SIRIS also provides good spatial resolution, freedom from matrix effects on surfaces at interfaces. In this paper we report the capability of to quantitate, accuracy depth dopant impurity concentrations in semiconductor devices 1013–1020 atoms/cm3 level. By utilizing layered GaAs/AlGaAs/GaAs samples grown by molecular...
Abstract The phosphoinositide 3-kinase (PI3K) pathway is deregulated in a range of cancers, and several targeted inhibitors are entering the clinic. This study aimed to investigate whether positron emission tomography tracer 3′-deoxy-3′-[18F]fluorothymidine ([18F]-FLT) suitable mark effect novel PI3K inhibitor GDC-0941, which has entered phase II clinical trial. CBA nude mice bearing U87 glioma HCT116 colorectal xenografts were imaged at baseline with [18F]-FLT acute (18 hours) chronic (186...
Antisense oligonucleotides (ASOs) have potential as anti-cancer agents by specifically modulating genes involved in tumorigenesis. However, little is known about ASO biodistribution and tissue pharmacokinetics (PKs) humans, including whether sufficient delivery to target tumor may be achieved. In this preliminary study human subjects, we used combined positron emission computed tomography (PET-CT) imaging subsequent modeling analysis of acquired dynamic data, examine the vivo PK properties...