A5078065682- Influenza Virus Research Studies
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Nosocomial Infections in ICU
- Surgical site infection prevention
- Streptococcal Infections and Treatments
- Infection Control in Healthcare
- Sepsis Diagnosis and Treatment
- Poxvirus research and outbreaks
- Urinary Tract Infections Management
- Infection Control and Ventilation
- Emergency and Acute Care Studies
- COVID-19 epidemiological studies
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Patient Safety and Medication Errors
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infections and Outbreaks Research
- Bacillus and Francisella bacterial research
- Clostridium difficile and Clostridium perfringens research
- Patient Satisfaction in Healthcare
- Bacterial Infections and Vaccines
Vanderbilt University Medical Center
2016-2025
University Hospital Southampton NHS Foundation Trust
2024-2025
Imperial College London
2022-2025
Southampton General Hospital
2024
Vanderbilt University
2014-2023
St John of God Hospital
2023
St John of God Subiaco Hospital
2023
Institut de Virologie
2021-2022
Fryderyk Chopin University of Music
2022
London Cancer
2022
Streptococcus pneumoniae is a serious infection in young infants. A heptavalent pneumococcal conjugate vaccine (PCV7) was licensed 2000 and recommended for all children aged 2 to 23 months.To determine the rates of invasive disease (IPD) infants before after PCV7 incorporated into childhood immunization schedule June 2000.A prospective, population-based study 0 90 days who resided areas 8 US states with active laboratory surveillance S infections from July 1, 1997, 30, 2004.Rates...
Syringomyelia causes progressive myelopathy. Most patients with syringomyelia have a Chiari I malformation of the cerebellar tonsils. Determination pathophysiological mechanisms underlying progression associated should improve strategies to halt myelopathy.The authors prospectively studied 20 adult both and symptomatic syringomyelia. Testing before surgery included following: clinical examination; evaluation anatomy by using T1-weighted magnetic resonance (MR) imaging; syrinx cerebrospinal...
We conducted a nested case–control study to examine the association between asthma and invasive pneumococcal disease. The population included persons 2 49 years of age who were enrolled in Tennessee's Medicaid program (TennCare) for more than one year during period (1995 through 2002) resided counties participating prospective laboratory-based surveillance For each subject with disease, 10 age-matched controls without disease randomly selected from same population. TennCare files queried...
Daily bathing of critically ill patients with the broad-spectrum, topical antimicrobial agent chlorhexidine is widely performed and may reduce health care-associated infections.To determine if daily decreases incidence infections.A pragmatic cluster randomized, crossover study 9340 admitted to 5 adult intensive care units a tertiary medical center in Nashville, Tennessee, from July 2012 through 2013.Units once-daily all disposable cloths impregnated 2% or nonantimicrobial as control. Bathing...
Background. We sought to determine the incidence of invasive pneumococcal disease (IPD) among individuals with sickle cell (SCD) before and after introduction conjugate vaccine (PCV).
Executive Summary This document serves as an update and companion piece to the 2005 Society for Healthcare Epidemiology of America (SHEA) Position Paper entitled “Influenza Vaccination Workers Vaccine Allocation During Shortages.” In large part, discussion about rationale influenza vaccination healthcare personnel (HCP), strategies designed improve rates in this population, recommendations made paper still stand. position notes new evidence released since publication strengthens SHEA's on...
To determine whether increases in contact isolation precautions are associated with decreased adherence to practices among healthcare workers (HCWs).Prospective cohort study from February 2009 October 2009.Eleven teaching hospitals.HCWs.One thousand thirteen observations conducted on HCWs. Additional data included the number of persons isolation, types HCWs, and hospital-specific precaution practices. Main outcome measures compliance individual components (hand hygiene before after patient...
Background. Invasive pneumococcal disease (IPD) is a burgeoning problem, with rates of antibiotic-nonsusceptible IPD, in particular, increasing during the past decade. One measure to combat IPD vaccination recently introduced 7-valent conjugate vaccine (PCV).
Influenza causes substantial morbidity and mortality annually, particularly in high-risk groups such as the elderly, young children, immunosuppressed individuals, individuals with chronic illnesses. Healthcare-associated transmission of influenza contributes to this burden but is often under-recognized except setting large outbreaks. The Centers for Disease Control Prevention has recommended annual vaccination healthcare workers (HCWs) direct patient contact since 1984 all HCWs 1993....
<h3>Context</h3> Bureaucratic organisational culture is less favourable to quality improvement, whereas organisations with group (teamwork) are better aligned for improvement. <h3>Objective</h3> To determine if an shows alignment patient safety climate. <h3>Design</h3> Cross-sectional administration of questionnaires. <h3>Setting</h3> 40 Hospital Corporation America hospitals. <h3>Participants</h3> 1406 nurses, ancillary staff, allied staff and physicians. <h3>Main outcome measures</h3>...
Abstract Objectives Blood culture contamination is a common problem in the emergency department ( ED ) that leads to unnecessary patient morbidity and health care costs. The study objective was develop evaluate effectiveness of quality improvement QI intervention for reducing blood an . Methods authors developed reduce then evaluated its prospective interrupted times series study. involved changing technique specimen collection from traditional clean procedure new sterile procedure, with...
To evaluate the impact of an institutional hand hygiene accountability program on healthcare personnel adherence.Time-series design with correlation analysis.Tertiary care academic medical center, including outpatient clinics and procedural areas.Medical center personnel.A comprehensive initiative was implemented in 2 major phases starting July 2009. Key facets included extensive project planning, leadership buy-in goal setting, financial incentives linked to performance, use a system-wide...
Abstract Objective: To characterize associations between exposures within and outside the medical workplace with healthcare personnel (HCP) SARS-CoV-2 infection, including effect of various forms respiratory protection. Design: Case–control study. Setting: We collected data from international participants via an online survey. Participants: In total, 1,130 HCP (244 cases laboratory-confirmed COVID-19, 886 controls healthy throughout pandemic) 67 countries not meeting prespecified exclusion...
The use of declination statements was associated with a mean increase 11.6% in influenza vaccination rates among healthcare workers at 22 hospitals. In most hospitals, there were no negative consequences for who refused to sign the forms, and policies implemented along other interventions designed rates.
Resistance to broad-spectrum antibiotics by gram-negative organisms is increasing. demands more resource utilization and associated with patient morbidity death. We describe the implementation of infection reduction protocols, including antibiotic stewardship, assess their impact on multi-drug-resistant (MDR) healthcare-acquired infections.Combined stewardship protocols were implemented in surgical trauma intensive care units at Vanderbilt University Hospital beginning 2002. The components...
Health care–associated infection (HAI) rates are used as measures of a health care facility's quality patient care. Recently, these outcomes have been to publicly rank efforts and determine facility reimbursement. The value comparing HAI among facilities is limited by many factors inherent surveillance, incentives that reward low can lead unintended consequences compromise medical surveillance efforts, such the use clinical adjudication panels veto events meet definitions. Healthcare...
Daptomycin-associated myopathy has been identified in 2%-14% of patients, and rhabdomyolysis is a known adverse effect. Although risk factors for daptomycin-associated are poorly defined, creatine phosphokinase (CPK) monitoring temporary discontinuation 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or "statins," recommended.
Abstract Objectives Blood culture contamination is a common and preventable problem in the emergency department ( ED ). In previous single‐center study, changing process of blood collection from traditional “clean,” nonsterile procedure to fully sterile with standardized use gloves, large‐volume chlorhexidine skin antisepsis, fenestrated drapes resulted substantial reduction contamination. The objective current study was evaluate effectiveness this for reducing two community hospital s....
Blood culture collection practices that reduce contamination, such as sterile blood kits and phlebotomy teams, increase up-front costs for collecting cultures but may lead to net savings by eliminating downstream associated with contamination. The study objective was compare overall hospital 3 strategies: usual care, kits, teams.Cost analysis.This analysis conducted from the perspective of a leadership team selecting strategy an adult emergency department (ED) 8,000 drawn annually.Total...
Managing acute asthma exacerbations in critical care can be challenging and may lead to adverse outcomes. While standard management of an exacerbation is well established outpatient emergency department settings, the pathway for patients with life-threatening near-fatal still needs fully defined. The use specific interventions such as intravenous ketamine, salbutamol, methylxanthines, which are often used combination improve bronchodilation, remains a contentious issue. Additionally,...