A5012998559- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Dietary Effects on Health
- Biochemical effects in animals
- Regulation of Appetite and Obesity
- Neurogenesis and neuroplasticity mechanisms
- PARP inhibition in cancer therapy
- Parkinson's Disease Mechanisms and Treatments
- Birth, Development, and Health
- Extracellular vesicles in disease
- Oral and gingival health research
- Calcium signaling and nucleotide metabolism
- Tuberous Sclerosis Complex Research
- Inflammatory Myopathies and Dermatomyositis
- Sleep and related disorders
- Bone Tumor Diagnosis and Treatments
- Alzheimer's disease research and treatments
- Radioactive Decay and Measurement Techniques
- Eicosanoids and Hypertension Pharmacology
- Myasthenia Gravis and Thymoma
- Nerve injury and regeneration
National Center for Geriatrics and Gerontology
2017-2025
Tohoku University
2022-2025
Washington University in St. Louis
2007-2018
Japan Agency for Medical Research and Development
2018
St. Luke's Clinic
2007
Taisho Pharmaceutical (Japan)
1999
Niigata University
1999
The Sir2 (silent information regulator 2) family of NAD-dependent deacetylases regulates aging and longevity across a wide variety organisms, including yeast, worms, flies. In mammals, the ortholog Sirt1 promotes fat mobilization, fatty acid oxidation, glucose production, insulin secretion in response to nutrient availability. We previously reported that an increased dosage pancreatic beta cells enhances glucose-stimulated (GSIS) improves tolerance cell-specific Sirt1-overexpressing (BESTO)...
<b><i>Article abstract</i></b> Heart tissues of patients with PD or incidental Lewy body (LB) disease (ILBD) were examined by light and electron microscopy. LBs α-synuclein–positive neurites identified in the hearts from 9 11 7 ILBD. present both tyrosine hydroxylase-positive -negative nerve processes, which are nerves extrinsic sympathetic intrinsic origin, respectively. These findings provide histologic evidence that postganglionic neurons heart involved process.
Diet restriction retards aging and extends lifespan by triggering adaptive mechanisms that alter behavioral, physiological, biochemical responses in mammals. Little is known about the molecular pathways evoking corresponding central response. One factor mediates effects of diet mammalian nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1. Here we demonstrate significantly increases SIRT1 protein levels induces neural activation dorsomedial lateral hypothalamic nuclei....
Summary Neuromuscular decline occurs with aging. The neuromuscular junction (NMJ), the interface between motor nerve and muscle, also undergoes age‐related changes. Aging effects on NMJ components—motor terminal, acetylcholine receptors (AChRs), nonmyelinating terminal Schwann cells (tSCs)—have not been comprehensively evaluated. Sirtuins delay mammalian aging increase longevity. Increased hypothalamic Sirt1 expression results in more youthful physiology, but relationship morphology was...
The dorsomedial hypothalamus (DMH) controls a number of essential physiological responses. We have demonstrated that the DMH plays an important role in regulation mammalian aging and longevity. To further dissect molecular basis function, we conducted microarray-based gene expression profiling with total RNA from laser-microdissected hypothalamic nuclei tried to find genes highly selectively expressed DMH. found neuropeptide VF precursor (Npvf), PR domain containing 13 (Prdm13), SK1 family...
Tuberous sclerosis complex (TSC) is a genetic disease related to hyperactivation of the mechanistic target rapamycin (mTOR) pathway and manifested by neurological symptoms, such as epilepsy sleep disorders. The pathophysiology dysfunction poorly understood likely multifactorial, but may involve intrinsic biological regulators in brain. Here, we characterized mouse model disorders TSC investigated mechanisms this conditional knockout involving inactivation Tsc1 gene neurons astrocytes...
Nicotinamide adenine dinucleotide (NAD
Old animals display significant alterations in sleep–wake patterns such as increases sleep fragmentation and propensity. Here, we demonstrated that PR-domain containing protein 13 (Prdm13)+ neurons the dorsomedial hypothalamus (DMH) are activated during deprivation (SD) young mice but not old mice. Chemogenetic inhibition of Prdm13+ DMH promotes increase attempts SD, suggesting its involvement control. Furthermore, DMH-specific Prdm13 -knockout (DMH- -KO) recapitulated age-associated...
Abstract Age-related tooth loss impedes mastication. Epidemiological and physiological studies have reported that poor oral hygiene occlusion are associated with cognitive decline. In the present study, we analyzed mechanism by which decreased occlusal support following bilateral extraction of maxillary first molars affects functions in young aged mice examined expression brain-function-related genes hippocampus hypothalamus. We observed working memory, enhanced restlessness, increased...
Sirtuins (SIRT1-7 in mammals) are evolutionarily conserved nicotinamide adenine dinucleotide-dependent lysine deacetylases/deacylases that regulate fundamental biological processes including aging. In this study, we reveal male Sirt7 knockout (KO) mice exhibited an extension of mean and maximum lifespan a delay the age-associated mortality rate. addition, aged KO displayed better glucose tolerance with improved insulin sensitivity compared wild-type (WT) mice. Fibroblast growth factor 21...
Sleep deprivation (SD) causes several adverse functional outcomes, and understanding the associated processes can improve quality of life. Although effects SD on neuronal activity in brain regions have been identified, a comprehensive evaluation whole is still lacking. Hence, we performed using two different methods, gentle handling dedicated chamber, targeted recombination active populations 2 (TRAP2) mice crossed with Rosa-ZsGreen reporter visualized cellular brain. Using semi-automated...