A5080019376- Glioma Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Genetic and Kidney Cyst Diseases
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Sleep and Wakefulness Research
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Genetic Syndromes and Imprinting
- Renal Diseases and Glomerulopathies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytokine Signaling Pathways and Interactions
- Muscle Physiology and Disorders
- Amyotrophic Lateral Sclerosis Research
- Phytochemistry Medicinal Plant Applications
- Pluripotent Stem Cells Research
- Renal and related cancers
- Electromagnetic Fields and Biological Effects
- Bone Metabolism and Diseases
- Neurofibromatosis and Schwannoma Cases
- Dietary Effects on Health
National Center for Geriatrics and Gerontology
2019-2024
Aichi Shukutoku University
2024
National Institute for Physiological Sciences
2001
University of Kansas Medical Center
2000
University Medical Center
2000
Fujita Health University
1995-2000
Muscle denervation at the neuromuscular junction (NMJ), essential synapse between motor neuron and skeletal muscle, is associated with age-related impairment. Therefore, improving muscle innervation aged NMJs may be an effective therapeutic strategy for treating We previously demonstrated that protein Dok-7 plays role in NMJ formation, and, indeed, its forced expression enlarges NMJs. Moreover, administration of adeno-associated virus vector encoding human (DOK7 gene therapy) suppressed...
Nicotinamide adenine dinucleotide (NAD
Aging progresses through the interaction of metabolic processes, including changes in immune and endocrine systems. Glucocorticoids (GCs), which are regulated by hypothalamic-pituitary-adrenal (HPA) axis, play an important role regulating metabolism responses. However, age-related secretion mechanisms GCs remain elusive. Here, we found that corticosterone (CORT) follows a circadian rhythm young mice, whereas it oversecreted throughout day aged mice >18 months old, resulting disappearance...
Abstract Age-related tooth loss impedes mastication. Epidemiological and physiological studies have reported that poor oral hygiene occlusion are associated with cognitive decline. In the present study, we analyzed mechanism by which decreased occlusal support following bilateral extraction of maxillary first molars affects functions in young aged mice examined expression brain-function-related genes hippocampus hypothalamus. We observed working memory, enhanced restlessness, increased...
Old animals display significant alterations in sleep–wake patterns such as increases sleep fragmentation and propensity. Here, we demonstrated that PR-domain containing protein 13 (Prdm13)+ neurons the dorsomedial hypothalamus (DMH) are activated during deprivation (SD) young mice but not old mice. Chemogenetic inhibition of Prdm13+ DMH promotes increase attempts SD, suggesting its involvement control. Furthermore, DMH-specific Prdm13 -knockout (DMH- -KO) recapitulated age-associated...
Abstract Background Regeneration of injured tissue is dependent on stem/progenitor cells, which can undergo proliferation and maturation processes to replace the lost cells extracellular matrix (ECM). Bone has a higher regenerative capacity than other tissues, with abundant mesenchymal progenitor in bone marrow, periosteum, surrounding muscle. However, treatment fractures not always successful; marked number clinical case reports have described nonunion or delayed healing for various...
Tooth bleaching has become one of the most frequently requested esthetic procedures in dental practice. A side effect is gingival irritation. This study examined efficacy propolis to treat irritation caused by vivo and vitro.Gingival was mimicked a mild burn injury oral mucosa young (10 week old) aged (18 month mice. Propolis ointment immediately applied area. After 24 h, gingiva collected determine hematoxylin eosin staining real-time polymerase chain reaction (PCR).Topical application...
Aging is an extremely complex biological process, and various models, from unicellular organisms to mammals, have been used in its research. The mouse the most widely model for studying human aging diseases due high homology well-established strategies genetic manipulation. Despite these advantages, maximum lifespan of laboratory mice nearly three years, which makes it time-consuming obtain animals desired age. To avoid this issue efficiently conduct research, National Center Geriatrics...
Abstract Gliomas are classified by combining histopathologic and molecular features, including isocitrate dehydrogenase (IDH) status. Although IDH-wild-type diffuse astrocytic glioma (DAG) shows a more aggressive phenotype than IDH-mutant type, lack of knowledge regarding relevant drivers for this type tumor has hindered the development therapeutic agents. Here, we examined human DAGs mouse model with mosaic analysis double markers (MADM) system, which concurrently lacks p53 NF1...
IL-6 is a cytokine that involved in various physiological and pathological conditions, approaches using gain-of-function transgenic animals have contributed elucidating function. However, studies of the multiple functions vivo are very time consuming because they require generation mice harbor gene encoding under control specific promoters to mimic different pathologies. Here, we report establishment conditional human mouse, LGL-IL6, which conditionally expresses by taking advantage...
Laboratory rats, like mice, are a type of animal commonly used in scientific investigations as well basic aging and geriatric research. The selection rat strain is an important first step the planning design experiment due to physiological, anatomical, ethological variations each strain, which may significantly modify expected results. In present study, we characterized age-related changes, from 3 months old (mo) 24 mo, three male strains medical research: RccHan®️:WIST (RccHan:WIST),...
Aging is a complex biological process. Several animal models, including nematodes, Drosophila, and rodents, have been used in research on aging mechanisms the extension of healthy life expectancy. The present study investigated physiological anatomical changes associated with two sub-strains aged C57BL/6 mice research: C57Bl/6NCrSlc (B6N) C57BL/6J (B6J). survival rate before 24 mo was higher B6J than B6N mice; however, after mo, it markedly lower former latter. Body weight increased male...
Abstract Background Dementia with Lewy bodies (DLB) is the second most common form of degenerative dementia in older people. The clinical feature DLB includes cognitive impairment, visual hallucinations, parkinsonism, and fluctuating attention. Three genes, SNCA (‐synuclein), APOE (apolipoprotein E), GBA (glucosylceramidase), have been convincingly demonstrated to be associated DLB. Our previous studies reported that a variant MFSD3 (rs143475431, c.888T>A:p.C296*) Japanese population...
<div>Abstract<p>Gliomas are classified by combining histopathologic and molecular features, including isocitrate dehydrogenase (<i>IDH</i>) status. Although <i>IDH</i>-wild-type diffuse astrocytic glioma (DAG) shows a more aggressive phenotype than <i>IDH</i>-mutant type, lack of knowledge regarding relevant drivers for this type tumor has hindered the development therapeutic agents. Here, we examined human DAGs mouse model with mosaic analysis...
<p>SF1: Loss of p53 and NF1 expression in MADM GFP-positive precancerous cells tumor cells; SF2: Clustering analysis gene status human gliomas; SF3: Expression levels epigenetic genes tumors, IDH-wild-type DAGs-MF DAGs-nonMF; SF4: Histone modifications Ezh2 wild-type tumors; SF5: Copy number located on chromosomes 7 10 the TM31 cell line; SF6: Relationship between RAS signaling pathway; SF7: Inhibition EZH2/PRC2 as a specific treatment strategy for DAGs-nonMF.</p>
<p>This file is the legends of Supplementary FigureS1-S7</p>
<p>This file explains the additional details of Materials and Methods</p>
<p>This file is the legends of Supplementary FigureS1-S7</p>