A5055178541- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Thyroid Cancer Diagnosis and Treatment
- Blood donation and transfusion practices
- Hepatitis B Virus Studies
- Blood disorders and treatments
- Cancer Cells and Metastasis
- Blood transfusion and management
- Cancer-related Molecular Pathways
- Genomics and Rare Diseases
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Parvovirus B19 Infection Studies
- Platelet Disorders and Treatments
- Viral Infections and Outbreaks Research
- Bone Tumor Diagnosis and Treatments
- Cholesterol and Lipid Metabolism
- Neutropenia and Cancer Infections
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Kruppel-like factors research
- Hematopoietic Stem Cell Transplantation
- T-cell and Retrovirus Studies
- Neurofibromatosis and Schwannoma Cases
- Wnt/β-catenin signaling in development and cancer
Canadian Blood Services
2020-2024
McMaster University
2023
University of Toronto
2023
National Institutes of Health Clinical Center
2016-2021
Barcelona Provincial Council
2021
University of Wisconsin–Madison
2012-2017
Medical College and Hospital, Kolkata
2017
Mission Hospital Durgapur
2017
UW Health University Hospital
2015
Baylor College of Medicine
2006-2010
Thyroid carcinoma is the most common endocrine malignancy, and papillary thyroid represents cancer. Papillary carcinomas that invade locally or metastasize are associated with a poor prognosis. We found that, during epithelial-mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1), cells acquired increased cancer stem cell-like features transcription factor paired-related homeobox protein 1 (PRRX1; alias PRX-1), newly identified EMT inducer, was markedly up-regulated....
Low- and middle-income countries (LMICs) remain neglected in the Coronavirus 19 (COVID-19) pandemic. COVID-19 convalescent plasma (CCP) (i.e. collected from individuals after their recovery COVID-19) has emerged as a leading medical treatment for COVID-19. Studies to date support safety-and increasingly efficacy-of CCP treat This motivated large-scale procurement transfusion of CCP, notably United States (US), where inventories have been attained, government-supported stockpiling is...
Identification of bona fide direct nuclear receptor gene targets has been challenging but essential for understanding regulation organismal physiological processes.We describe a methodology to identify transcription factor binding sites and target genes in vivo by intersecting microarray data, computational site queries, evolutionary conservation. We provide detailed experimental validation each step and, as proof principle, utilize the novel orphan NR2F1 (COUP-TFI). The first involved...
Blood transfusions save millions of lives worldwide each year, yet formation antibodies against non-self antigens remains a significant problem, particularly in frequently transfused patients. We designed and tested the Universal Donor Typing (UBDT_PC1) array for automated high-throughput simultaneous typing human erythroid, platelet, leukocyte, neutrophil (HEA, HPA, HLA, HNA, respectively) to support selection blood products matched beyond ABO/Rh. samples from 6946 donors European, African,...
Few studies have documented the blood group antigens in population of eastern India. Frequencies some common alleles and haplotypes were unknown. We describe phenotype, allele, haplotype frequencies state West Bengal, India.We tested 1,528 donors at Medical College Hospital, Kolkata. The ABO, Rhesus, Kell systems determined by standard serologic methods tubes. Allele calculated with an iterative method that yielded maximum-likelihood estimates under assumption a Hardy-Weinberg...
The 1000 Genomes Project provides a database of genomic variants from whole genome sequencing 2504 individuals across five continental superpopulations. This can enrich our background knowledge worldwide blood group variant geographic distribution and identify novel potential clinical significance.The was analyzed to 1) expand about distributions known variants, 2) with antigenic their association, 3) establish baseline scaffold chromosomal coordinates translate next-generation output files...
Abstract Background and Objectives The distribution of rare specific red cell phenotypes varies between races ethnicities. Therefore, the most compatible units for patients with haemoglobinopathies other blood requirements are likely to be found in donors from similar genetic backgrounds. Our service introduced a voluntary question asking provide their racial background/ethnicity. Results triggered additional phenotyping and/or genotyping. Materials Methods We analysed results testing...
Disseminated Fusarium infection is associated with high mortality in immunocompromised patients. Patients acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation and hematopoietic stem cell transplantation (SCT). There no consensus regarding management invasive disseminated infections the setting prolonged (Tortorano et al., 2014) [1]. We report a case patient relapsed AML who underwent successful chemotherapy...
Abstract Background and objectives Next generation sequencing (NGS) has promising applications in transfusion medicine. Exome (ES) is increasingly used the clinical setting, blood group interpretation an additional value that could be extracted from existing data sets. We provide first release of open‐source software tailored for this purpose describe its validation with three systems. Materials methods The DTM‐Tools algorithm was designed to analyse 1018 ES NGS files ClinSeq ® cohort....