A5053682255- Blood groups and transfusion
- Blood disorders and treatments
- Erythrocyte Function and Pathophysiology
- Neutropenia and Cancer Infections
- Hemoglobinopathies and Related Disorders
Blood transfusions save millions of lives worldwide each year, yet formation antibodies against non-self antigens remains a significant problem, particularly in frequently transfused patients. We designed and tested the Universal Donor Typing (UBDT_PC1) array for automated high-throughput simultaneous typing human erythroid, platelet, leukocyte, neutrophil (HEA, HPA, HLA, HNA, respectively) to support selection blood products matched beyond ABO/Rh. samples from 6946 donors European, African,...
Antigranulocyte antibodies are involved in the pathophysiology of a number clinical disorders, which include: febrile transfusion reactions, severe pulmonary reactions to transfusion, auto-immune neutropenia, drug-induced and iso-immune neonatal neutropenia. Owing inherent difficulties manipulating granulocytes vitro, many serological techniques described for detection antigranulocyte complex sometimes difficult reproduce. We describe alloreactive granulocyte using flow cytometric analysis...