A5015848013- Respiratory Support and Mechanisms
- RNA modifications and cancer
- RNA Research and Splicing
- Intensive Care Unit Cognitive Disorders
- Neurogenetic and Muscular Disorders Research
- Proteoglycans and glycosaminoglycans research
- Cancer-related molecular mechanisms research
- Cardiac Arrest and Resuscitation
- Photoacoustic and Ultrasonic Imaging
- Plant Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Software-Defined Networks and 5G
- Digital Media and Visual Art
- Long-Term Effects of COVID-19
- Mechanical Circulatory Support Devices
- Airway Management and Intubation Techniques
- Advancements in Photolithography Techniques
- Robotic Path Planning Algorithms
- Data Management and Algorithms
- Image Enhancement Techniques
- Network Traffic and Congestion Control
- Hearing, Cochlea, Tinnitus, Genetics
- Sparse and Compressive Sensing Techniques
- Organic Light-Emitting Diodes Research
- Children's Physical and Motor Development
Changchun University of Science and Technology
2010-2025
Nanjing University of Information Science and Technology
2021-2025
State Key Laboratory of Biotherapy
2018-2024
Sichuan University
2018-2024
Shanxi Agricultural University
2023-2024
State Key Laboratory of Respiratory Disease
2020-2023
Guangzhou Medical University
2020-2023
First Affiliated Hospital of Guangzhou Medical University
2020-2023
Harbin Institute of Technology
2023
H.S. Skovoroda Kharkiv National Pedagogical University
2021-2022
Speech self-supervised models such as wav2vec 2.0 and HuBERT are making revolutionary progress in Automatic Recognition (ASR). However, they have not been totally proven to produce better performance on tasks other than ASR. In this work, we explored partial fine-tuning entire pre-trained for three non-ASR speech tasks: Emotion Recognition, Speaker Verification Spoken Language Understanding. With simple proposed downstream frameworks, the best scores reached 79.58% weighted accuracy...
Imitating the behavioral traits or structures of biological organisms can provide new ideas and operating principles for designing microactuators. Inspired by locomotion koalas, a lightweight self-locomotion piezoelectric actuator (SLPA) is developed. Based on hybrid longitudinal bending vibration modes, proposed SLPA able to obtain linear locomotion. The configuration designed based thin metal plate with miniature size 19.5 × 1.1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
F1Fo-ATP synthase was originally thought to exclusively locate in the inner membrane of mitochondria. However, recent studies prove existence ectopic on outside cell membrane. Ectopic ATP proposed as a marker for tumor target therapy. Nevertheless, protein transport mechanism is still unclear. The specificity synthase, with regard tumors, questioned because its widespread expression. In current study, we constructed green fluorescent protein-ATP5B fusion and introduced it into HepG2 cells...
With the rapid development of mobile data acquisition technology, volume available spatial is growing at an increasingly fast pace. The real-time processing big has become a research frontier in field Geographic Information Systems (GIS). To cope with these highly dynamic data, we aim to reduce time complexity updating by modifying traditional index. However, existing algorithms and structures are based on single work nodes, which incapable handling required high numbers update rates moving...
The limited thermostability and storage-induced inactivation of Moloney murine leukemia virus reverse transcriptase (MMLV RT) have constrained its applications. In this study, a high-stability mutant, MMLV RT-SV, was generated through multi-site mutagenesis strategy targeting the nucleic acid-binding pocket. Through de novo protein design, three highly negatively charged binders with affinities 45 nM, 362 829 nM were developed to specifically target positively region on surface RT-SV....
Abstract Eukaryotes harbor both Sm-type and Lsm-type heteroheptameric rings, which are essential in RNA metabolism. Despite their similar subunits evolutionary ties, they interact with distinct ways, functioning as scaffolds chaperones, respectively. However, the mechanistic basis of divergence remains unclear. Using Sm ring (D1-D2-F-E-G-D3-B) Lsm2-8 ring, form cores spliceosomal snRNPs, model systems, we investigated feasibility mechanisms interconversion. We found that interactions among...
Abstract Objective: The present study aimed to investigate circular RNA (circRNA) expression in uveal melanoma (UM). Methods: First, we used microarray compare the profiles of circRNA five UM samples and normal uvea tissues. Next, bioinformatics analyses, including gene ontology (GO) analysis pathway analysis, were applied these differentially expressed circRNAs predict pathogenic pathways that may be involved. Quantitative real-time polymerase chain reaction (qRT-PCR) 20 was confirm...
It has been established that hyaluronic acid (HA) glycans (nHA) and oligosaccharide (oHA) exert different effects on the biological function of vascular endothelial cell (EC), resulting in altered regulation angiogenesis. However, specific mechanism is still unclear. Our study focused nHA oHA ezrin merlin proteins EC. The expression was silenced by siRNA, EC growth as well mRNA activation (phosphorylation) stimulated investigated. results revealed when treated with nHA, there no significant...
Hearing defects can significantly influence quality of life for those who experience them.At this time, 177 deafness genes have been cloned, including 134 non-syndromic hearing-loss genes.The methionine sulfoxide reductase B3 (Ahmed et al., 2011) gene (also called DFNB74) is one such newly discovered gene.Within c.265 T>G andc.55T>C mutations are associated with autosomal recessive hearing loss.However, the biological role and mechanism underlying how it contributes to unclear.Thus, better...
DNA methylation plays an important role for mammalian development. However, it is unclear whether the pattern evolutionarily conserved. The Y chromosome serves as a powerful tool study of human evolution because transferred between males. In this study, based on deep-rooted pedigrees and latest phylogenetic tree, we performed epigenetic analysis from 72 donors. By comparing their respective level, found that was stable among family members haplogroups. Interestingly, two haplogroup-specific...
Purpose: Lymphatic vessel endothelial hyaluronan receptor (LYVE-1), a specific molecular marker for lymph systems, has only one known ligand, (HA). Many studies have reported that HA, on the surface of tumor cells, is associated with metastatic behavior cancer cells. The interaction LYVE-1 HA may facilitate cell attachment and enhance dissemination cells to nodes. aim this study was explore biological function determine whether between directly involved in adhesion lymphatic vessels....
Abstract The assembly of snRNP cores, in which seven Sm proteins, D1/D2/F/E/G/D3/B, form a ring around the nonameric site snRNAs, is early step spliceosome formation and essential to eukaryotes. It mediated by PMRT5 SMN complexes sequentially vivo. deficiency causes neurodegenerative disease spinal muscular atrophy (SMA). How complex assembles cores largely unknown, especially how achieves high RNA specificity it released. Here we show, using crystallographic biochemical approaches, that...
At present, researchers have made great progress in the research of object detection, however, these studies mainly focus on detection images under normal lighting, ignoring target low light. And fields automatic driving at night and surveillance are usually obtained low-light environments. These problems such as poor brightness, contrast, obvious noise, which lead to a large amount information loss image. performance light is reduced. In this paper, we propose image enhancement method based...
The efficiency of single-junction solar cells is limited to about 30% (the Shockley-Queisser limit). Spectral mismatch losses (transparency low-energy photons, thermalization high-energy photons) strongly contribute lowering the maximum efficiency. To reduce losses, photon splitting proposed and observed for a variety lanthanide-doped materials. For ${\mathrm{Er}}^{3+}$, even one-to-three photon-splitting process has been reported, yielding three IR photons at around 1530 nm following...
Abstract China is the world’s largest producer of sweet potato ( Ipomoea batatas (L.) Lam.). Considering that there are numerous potato-producing regions in and a vegetatively propagated crop, genetic diversity viruses could be high country. However, studies on species variabilities limited, making it difficult to prevent control viral diseases this crop. During 2014–2019, samples with disease-like symptoms were randomly collected from fields 25 provinces China. Twenty-one virus species,...
The spliceosomal snRNP cores, each comprised of a snRNA and seven-membered Sm ring (D1/D2/F/E/G/D3/B), are assembled by twelve chaperoning proteins in human. However, only six assembly-assisting proteins, ICln the SMN complex (SMN/Gemin2/Gemin6-8), have been found Schizosaccharomyces pombe (Sp). Here, we used recombinant to reconstitute chaperone machinery investigated roles these systematically. We that, like human system, assembly S. requires sequentially. there several significant...