A5078934093- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Pregnancy and preeclampsia studies
- Spinal Dysraphism and Malformations
- Congenital Anomalies and Fetal Surgery
- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Birth, Development, and Health
- Parvovirus B19 Infection Studies
- COVID-19 Impact on Reproduction
- Teratomas and Epidermoid Cysts
- Family and Disability Support Research
- Pediatric Hepatobiliary Diseases and Treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Hemoglobinopathies and Related Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Fungal Infections and Studies
- Maternal and fetal healthcare
- Emergency and Acute Care Studies
- Abdominal Trauma and Injuries
- Connective tissue disorders research
- COVID-19 epidemiological studies
- Organ Transplantation Techniques and Outcomes
- Esophageal and GI Pathology
Nationwide Children's Hospital
2023-2025
Hospital Universitario Austral
2011-2022
Austral University
2021
Hudson Institute
2019
John Wiley & Sons (United Kingdom)
2019
University of Cambridge
2009
Weatherford College
2009
Harris Birthright Research Centre for Fetal Medicine
2009
King's College Hospital
2009
University of Plymouth
2009
Abstract Objective To examine the performance of new algorithm in screening for trisomy 21 by a combination maternal age, fetal nuchal translucency (NT) and serum free β‐human chorionic gonadotropin (β‐hCG) pregnancy‐associated plasma protein‐A (PAPP‐A). Methods This was prospective study singleton pregnancies at 11 + 0 to 13 6 weeks gestation using an combining NT thickness based on mixture model assessment NT, β‐hCG PAPP‐A multiple regression biochemistry. The measurements were performed...
Abstract Objectives To examine the effect of deviations in median nuchal translucency thickness (NT) and spread measurements on performance screening for trisomy 21 by maternal age fetal NT, age, NT serum biochemistry. Methods We simulated multiples values pregnancy‐associated plasma protein‐A (PAPP‐A) free β‐human chorionic gonadotropin (β‐hCG) 500 000 euploid pregnancies at 12 weeks gestation. Detection rates false‐positive were calculated without adjustments adding or subtracting ranging...
To describe the contribution of 3-dimensional computed tomography (3D-CT) in prenatal diagnosis skeletal dysplasias (SD) a cohort patients with inconclusive by ultrasound (US).Between May 2007 and February 2010, six pregnant women suspected fetal SD on US examination but no specific were studied 3D-CT. The images evaluated multidisciplinary team who proposed likely diagnosis. Further postnatal workup included clinical radiological evaluation all cases. Prenatal diagnoses compared.The use...
<i>Objectives:</i> To investigate whether the maternal serum concentration of activin A at 11–13 weeks gestation in pregnancies that subsequently develop hypertensive disorders is different from those with a normal outcome and to examine any possible differences are related uterine artery pulsatility index (PI), pregnancy-associated plasma protein (PAPP-A) tumor necrosis factor-α receptor-1 (TNF-R1). <i>Material Methods:</i> Serum A, TNF-R1, PAPP-A PI were determined...
Abstract Objective To evaluate natural history of fetuses congenital diaphragmatic hernia (CDH) prenatally diagnosed in countries where termination pregnancy is not legally allowed and to predict neonatal survival according lung area liver herniation. Methods Prospective study including antenatally CDH cases managed expectantly during six tertiary Latin American centres. The contribution the observed/expected lung‐to‐head ratio (O/E‐LHR) herniation predicting was assessed. Results From total...
Introduction: Molybdenum cofactor deficiency (MoCD) is a rare, lethal disorder characterized by early-onset encephalopathy and seizures. In 2021, fosdenopterin (NulibryTM) became the first FDA-approved treatment for MoCD type A (MoCD-A). Case Presentation: G3P2 woman with prior affected child underwent prenatal diagnosis of MoCD-A at 16 weeks via amniocentesis. Fetal Magnetic Resonance Imaging (MRI) 22 was normal but showed mega cisterna magna 28 weeks. Concerns ongoing brain damage led to...
To determine the historical aspects, current availability, and clinical outcomes of open intrauterine repair spina bifida aperta (IRSBA) in Spanish-speaking Latin American countries.Cases were collected from centers with at least 2 years experience a minimum 10 IRSBA interventions by December 2020. Clinical variables compared to results Management Myelomeningocele Study (MOMS) trial.Clinical 314 cases seven was reviewed. Most (n = 189, 60.2%) performed between 24 25.9 weeks' gestation....
The single most effective marker for all major chromosomal defects including trisomy 21 (T-21) is the first trimester fetal nuchal translucency thickness (NT). Accurate measurement of NT to screen abnormalities requires appropriate training, adherence a standard ultrasound technique, and regular audits performance. investigators theorized that an underestimate in by individual sonographers would reduce estimated risk Down syndrome thus overall screen-positive rate; overestimate increase both...
A 30-year-old gravida 2, para 1 pregnant woman underwent fetal ultrasonography at 33 5/7 weeks, which was suggestive of duodenal atresia (DA). Her initial pregnancy course uncomplicated, and routine anatomy 20 weeks' gestation did not reveal any signs DA. She had a normal cell-free DNA screening. Follow-up growth revealed the typical sonographic dyad classic "double-bubble" sign found in DA along with polyhydramnios an amniotic fluid index (AFI) 31 cm (Fig 1). The patient then referred to...
Abstract Objective To evaluate survival outcomes of fetuses with right sided congenital diaphragmatic hernia (CDH) treated in Latin American centres and to assess the utility left lung area predict neonatal survival. Methods A retrospective cohort including isolated CDH cases managed expectantly during pregnancy six tertiary centers from five countries. The observed/expected lung‐to‐head ratio (O/E‐LHR) predicting was assessed, best cut‐off prognosis automatically selected by decision tree...
Abstract Objective To evaluate maternal and perinatal outcomes of late open fetal repair for spina bifida (OSB) between 26 +0 –27 +6 weeks. Methods A cohort fetuses with OSB who underwent surgery in two centers (Argentina Mexico). Two groups were defined based on the gestational age (GA) at intervention: Management Myelomeningocele Study (MOMS) time window group: GA 19 –25 , intervention . Results Intrauterine was successfully performed 140 cases, either before ( n = 57) or after 83) weeks,...
The aim of this study is to describe the surgical technique, obstetrical evolution, and perinatal outcomes a cohort fetuses undergoing intrauterine surgery repair open spina bifida (OSB).We performed prospective analysis 21 consecutive with OSB at our institution between 2015 2017. technique was similar that described in management myelomeningocele (MOMS) (Funded by National Institutes Health; ClinicalTrials.gov number, NCT00060606) trial, except hysterotomy using bipolar dissector....
We report a case of newborn with two synchronous tumors—sialoblastoma and hepatoblastoma—diagnosed at 20 weeks gestation by magnetic resonance imaging (MRI) ultrasonography (US). The aim this study was to describe the management together review literature. Our patient had large facial tumor associated extremely high alpha-fetoprotein levels. Diagnosis tumors made surgical biopsy, showing typical features in both. Sialoblastoma is potentially aggressive tumor. In our case, Ki67 index...
Background: Spina bifida (SB) is a relatively common birth defect with the highest prevalence among Hispanics. A randomized controlled trial (MOMS) demonstrated that prenatal repair yielded improved outcomes compared to postnatal repair. However, social determinants of health can significantly impact overall well-being affected individuals or their eligibility for some these evidenced-based interventions. Methods: We conducted retrospective observational study describe and compare mean Child...
Objective This study was aimed to explore the attitude of Argentinean neonatologists in delivery room on resuscitating infants with trisomies. Study Design An anonymous questionnaire completed by staffing level-III neonatal intensive care units (NICUs) resuscitation children trisomies 21, 18, and 13. Potential sociocultural factors influencing decision resuscitate were included. Results Overall, 314 34 Buenos Aires region participated (response rate 54%). The position regarding that 98%...
Background: Emerging pandemic viruses may have multiple deleterious effects on maternal health. This study examines of a influenza virus cause-specific mortality time series, using Argentinian vital statistics.Methods: We conducted population-based natural experiment from national records deaths between 1980 and 2017. Joinpoint regression models were used to model series the ratio (MMR). The sensitivity registry detect H1N1 2009 MMR was analysed panel parallel interrupted (ITS).Findings:...
Emerging pandemic viruses may have multiple deleterious effects on maternal health. This study examines the of a influenza virus cause-specific mortality time series, using Argentinian vital statistics.We conducted population-based natural experiment from national records deaths between 1980 and 2017. Joinpoint regression models were used to model series ratio (MMR). The sensitivity registry detect H1N1 2009 MMR was analysed panel parallel interrupted (ITS).Over this 38-year study, decreased...
To evaluate the value of cerebroplacental ratio (CPR) at term as a marker antepartum placental reserve. This was retrospective cohort study patients with singleton pregnancy who had Doppler evaluation within 2 weeks delivery in single tertiary centre between November 2011 and September 2015. Out 559 initial pregnancies, we excluded 28 (5%) fetal anomalies, 23 incomplete perinatal data (4.1%) 12 an elective Caesarean section (2.1%). We defined Intrapartum for distress (ICFD) to those...
To evaluate natural history of fetuses congenital diaphragmatic hernia (CDH) prenatally diagnosed in countries where termination pregnancy is not legally allowed and to predict neonatal survival according lung area liver herniation. Prospective study including antenatally CDH cases managed expectantly during six tertiary Latin American centres. The contribution the observed/expected lung-to-head ratio (O/E-LHR) herniation predicting was assessed. From total population 380 cases, 144 isolated...