A5054315174- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Research Data Management Practices
- Acute Ischemic Stroke Management
- Advanced X-ray and CT Imaging
- Scientific Computing and Data Management
- Sarcoidosis and Beryllium Toxicity Research
- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Cloud Computing and Remote Desktop Technologies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
- Distributed and Parallel Computing Systems
- Multimedia Communication and Technology
- Cardiovascular Disease and Adiposity
- Open Source Software Innovations
- Molecular Biology Techniques and Applications
- Biomedical and Engineering Education
- vaccines and immunoinformatics approaches
- Lung Cancer Diagnosis and Treatment
- Peer-to-Peer Network Technologies
- Biomedical Text Mining and Ontologies
- Immunotherapy and Immune Responses
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
GE Global Research (United States)
2003-2024
General Electric (United States)
1991-2003
Limitations on the number of unique protein and DNA molecules that can be characterized microscopically in a single tissue specimen impede advances understanding biological basis health disease. Here we present multiplexed fluorescence microscopy method (MxIF) for quantitative, single-cell, subcellular characterization multiple analytes formalin-fixed paraffin-embedded tissue. Chemical inactivation fluorescent dyes after each image acquisition round allows reuse common iterative staining...
Pulmonary sarcoidosis is a multisystem granulomatous interstitial lung disease (ILD) with variable presentation and prognosis. The early accurate detection of pulmonary may prevent progression to fibrosis, serious potentially life-threatening form the disease. However, lack gold-standard diagnostic test specific radiographic findings poses challenges in diagnosing sarcoidosis. Chest computed tomography (CT) imaging commonly used but requires expert, chest-trained radiologists differentiate...
article Free Access Share on Implementing shared manufacturing services the World-Wide Web Authors: J. W. Erkes GE Corporate Research & Development, P.O. Box 8, KW-C276A, Schenectady, NY NYView Profile , K. B. Kenny KW-C273, Lewis KW-C277, D. Sarachan M. Sobolewski KW-C276B, R. N. Sum KW-C279, Authors Info Claims Communications of ACMVolume 39Issue 2Feb. 1996pp 34–45https://doi.org/10.1145/230798.230802Published:01 February 1996Publication History 45citation1,018DownloadsMetricsTotal...
Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy. Spatial relationships among cells including stromal in the tumor microenvironment (TME) key contributors heterogeneity.We demonstrate how quantify from immunofluorescence pathology samples, using a set 3 basic breast as test case. We learn dominant biomarker intensity patterns map distribution with network. then describe pairwise...
Pulmonary sarcoidosis (PS) is an inflammatory interstitial lung disease, causing clusters of inflamed tissue called 'granulomas' within the lung. However, PS may mimic other conditions such as malignancy or infection, which often leads to a delayed diagnosis, leading worsening respiratory function. Chest computed tomography (CT) used diagnose but with varying specificities, appearance and diffuse diseases on chest CT are myriad considered difficult by many radiologists. In this work we...
We introduce THRIVE (Tumor Heterogeneity Research Interactive Visualization Environment), an open-source tool developed to assist cancer researchers in interactive hypothesis testing. The focus of this is quantify spatial intratumoral heterogeneity (ITH), and the interactions between different cell phenotypes noncellular constituents. Specifically, we foresee applications phenotyping cells within tumor microenvironments, recognizing boundaries, identifying degrees immune infiltration...
Pulmonary sarcoidosis is a multisystem granulomatous interstitial lung disease (ILD) with variable presentation and prognosis. Early accurate detection of pulmonary may prevent progression to fibrosis, serious potentially life-threatening form the disease. However, lack gold-standard diagnostic test specific radiographic findings pose challenges in diagnosing sarcoidosis. Chest computed tomography (CT) imaging commonly used but requires expert, chest-trained radiologists differentiate from...
Key bioinformatics and medical informatics research areas need to be identified advance knowledge understanding of disease risk factors molecular pathology in the 21 st century toward new diagnoses, prognoses, treatments.Three high-impact are identified: predictive medicine (to identify significant correlations within clinical data using statistical artificial intelligence methods), along with pathway cellular simulations (that combine biological advanced elucidate pathology).Initial models...
<div>Abstract<p>We introduce THRIVE (Tumor Heterogeneity Research Interactive Visualization Environment), an open-source tool developed to assist cancer researchers in interactive hypothesis testing. The focus of this is quantify spatial intratumoral heterogeneity (ITH), and the interactions between different cell phenotypes noncellular constituents. Specifically, we foresee applications phenotyping cells within tumor microenvironments, recognizing boundaries, identifying degrees...
<div>Abstract<p>We introduce THRIVE (Tumor Heterogeneity Research Interactive Visualization Environment), an open-source tool developed to assist cancer researchers in interactive hypothesis testing. The focus of this is quantify spatial intratumoral heterogeneity (ITH), and the interactions between different cell phenotypes noncellular constituents. Specifically, we foresee applications phenotyping cells within tumor microenvironments, recognizing boundaries, identifying degrees...
<p>THRIVE computer resource.</p>
<p>THRIVE computer resource.</p>
The Sustainability and Industry Partnership Work Group (SIP-WG) is a part of the National Cancer Institute Informatics Technology for Research (ITCR) program. charter SIP-WG to investigate options long-term sustainability open source software (OSS) developed by ITCR, in developing collection business model archetypes that can serve as plans ITCR OSS development initiatives. workgroup assembled models from program, other studies, via engagement its extensive network relationships with...
Focusing multi-pinhole (MP) collimators are increasingly being used for small animal as well targeted VOI imaging. We use focused MP to improve the resolution and sensitivity of photons detected from striatal region brain. Simulations were based on activity distributions derived clinical SPECT images normal Parkinson's Disease patients injected with 99mTc-Trodat. Radioactive counts extracted mapped onto regions Zubal brain phantom input into simulator. Simulated then generated modeling...
Abstract Numerous engineering application systems have been developed over the past twenty years, and many of these applications will continue to be used for years come. Examples such include CAD Systems, finite‐element analysis packages inspection systems. Because were before graphical workstations became available, they often simple command‐line user interfaces. Thus, there is a need interface management system (UIMS) that can build point‐and‐click style interfaces existing applications....
The ability to predict antigenic sites on proteins is crucial for the production of synthetic peptide vaccines and probes antibody structure. Large number amino acid propensity scales based various properties like hydrophilicity, flexibility/mobility, turns bends have been proposed tested previously. However these methods are not very accurate in predicting epitopes non-epitope regions. We propose algorithms that combine 14 best performing individual give better prediction accuracy as...
<sec> <title>BACKGROUND</title> The National Cancer Institute Informatics Technology for Research (ITCR) program provides a series of funding mechanisms to create an ecosystem open-source software (OSS) that serves the needs cancer research. As ITCR substantially grows, it faces challenge long-term sustainability being developed by grantees. To address this challenge, and industry partnership working group (SIP-WG) was convened in 2019. </sec> <title>OBJECTIVE</title> charter SIP-WG is...