A5023553402- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Dialysis and Renal Disease Management
- Bioactive Compounds and Antitumor Agents
- Marine Sponges and Natural Products
- Nitric Oxide and Endothelin Effects
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Renin-Angiotensin System Studies
- Fermentation and Sensory Analysis
- Phytochemical compounds biological activities
- Geochemistry and Geologic Mapping
- Geological and Geochemical Analysis
- Neurological and metabolic disorders
- Peptidase Inhibition and Analysis
- Antifungal resistance and susceptibility
- Enzyme Production and Characterization
- Chronic Kidney Disease and Diabetes
- Microbial Metabolism and Applications
- Radioactive element chemistry and processing
- Food Quality and Safety Studies
- Advanced Radiotherapy Techniques
- Plant biochemistry and biosynthesis
- Renal Diseases and Glomerulopathies
Kinan Hospital
2018-2024
Shibuya (Japan)
2023
Tokyo Metropolitan Geriatric Hospital
2020-2021
Kyoto University Hospital
2008-2021
Suita Tokushukai Hospital
2020-2021
British Heart Foundation
2018
Medical Research Council
2018
Cancer Research UK
2018
University of Oxford
2018
Wakayama Medical University
2018
A nationwide statistical survey of 4255 dialysis facilities was conducted at the end 2011. Responses were submitted by 4213 (99.0%). The number new patients started on 38,613 in Although decreased 2009 and 2010, it increased who died each year has been increasing; 30,743 2011, which exceeded 30,000 for first time. undergoing also increasing every year; 304,856 300,000 per million 2011 2385.4. crude death rate 10.2%, 10% time last 20 years. mean age 67.84 years entire patient population 66.55...
Adenosine coordinates organ metabolism and blood supply, it modulates immune responses. In the kidney mediates vascular response elicited by changes in NaCl concentration macula densa region of nephron, thereby serving as an important regulator GFR. To determine whether adenosine formation depends on extracellular nucleotide hydrolysis, we studied NaCl-dependent GFR regulation (tubuloglomerular feedback) mice with targeted deletion ecto-5'-nucleotidase/CD73 (e-5'NT/CD73), enzyme responsible...
A nationwide statistical survey of 4124 dialysis facilities was conducted at the end 2008 and 4081 (99.0%) responded. The number patients undergoing determined to be 283,421, an increase 8179 (3.0%) compared with that 2007. per million 2220. crude death rate from 2007 9.8%. mean age new begun on 67.2 years entire patient population 65.3 years. For primary diseases dialysis, percentages diabetic nephropathy chronic glomerulonephritis were 43.3% 22.8%, respectively. Among measured bacterial...
Abstract A nationwide statistical survey of 4226 dialysis facilities was conducted at the end 2010, and 4166 (98.6%) responded. The number new patients introduced into 37 512 in 2010. This has decreased for two consecutive years since it peaked 2008. who died 2010 28 882, which been increasing every year. undergoing 298 252, is an increase 7591 (2.6%) compared with that 2009. per million 2329.1. crude death rate 9.8%, gradually increasing. mean age 67.8 entire patient population 66.2 years....
Abstract A nationwide statistical survey of 4098 dialysis facilities was conducted at the end 2007, and 4052 (98.88%) participated. The number patients undergoing 2007 determined to be 275 242, an increase 10 769 (4.1%) compared with that 2006.The per million 2154. crude death rate from 2006 9.4%. mean age new begun on 66.8 years entire patient population 64.9 years. For primary diseases dialysis, percentages diabetic nephropathy chronic glomerulonephritis were 43.4% 23.8%, respectively....
Abstract A nationwide statistical survey of 4196 dialysis facilities was conducted at the end 2009, and 4133 (98.5%) responded. The number patients undergoing 2009 determined to be 290 661, an increase 7240 (2.6%) compared with that 2008. per million 2279.5. crude death rate from 2008 9.6%. mean age new introduced into 67.3 years old entire patient population 65.8 old. Primary diseases such as diabetic nephropathy chronic glomerulonephritis for patients, showed a percentage 44.5% 21.9%,...
The present experiments in mice were performed to determine the steady-state effects of exogenous adenosine on vascular resistance whole kidney, superficial blood vessels, and afferent arterioles. effect an intravenous infusion (5, 10, 20 μg/min) wild-type was vasodilatation as evidenced by significant reductions renal resistance. Resistance decreases augmented 1 receptor (A1AR) –/– mice. Renal A2aAR agonist CGS 21680A...
In the present experiments we examined renovascular constrictor effects of ANG II in chronic and complete absence A1 adenosine receptors (A1AR) using mice with targeted deletion A1AR gene. Glomerular filtration rate (GFR) was not different between +/+ -/- under control conditions (450.5 ± 60 vs. 475.2 62.5 μl/min) but fell significantly less during infusion at 1.5 ng/min (A1AR +/+: 242 32.5 μl/min, -/-: 371 42 μl/min; P = 0.03). Bolus injection 1, 10, 100 ng reduced renal blood flow...
To determine the role of local renin-angiotensin system in renal function, micropuncture was performed on two lines mice which genetic changes to angiotensin-converting enzyme (ACE) gene markedly reduced or eliminated expression tissue ACE. Whereas blood pressure is low one line (ACE 2/2), it normal other 1/3) due ectopic hepatic ACE expression. When normalized for size, levels glomerular filtration rate [GFR; microl x min(-1) g kidney wt(-1) (KW)] and single-nephron GFR (SNGFR; nl KW(-1))...
Adjustments of renal vascular resistance in response to changes blood pressure are mediated by an interplay between the myocyte-inherent myogenic and kidney-specific tubuloglomerular feedback (TGF) mechanisms. Using mice with deletion A(1) adenosine receptor (A1AR) gene, we tested prediction that absence TGF, previously established result from A1AR deficiency, is associated a reduction efficiency autoregulation. In anesthetized wild-type (A1AR+/+) A1AR-deficient (A1AR-/-), glomerular...
This study evaluated the oncologic outcomes and complications of cervical cancer patients in terms CT-based image-guided brachytherapy (IGBT) parameters. Of 68 treated with definitive radiotherapy/concurrent chemoradiotherapy, most received whole-pelvis external beam RT (EBRT) 40 Gy 20 fractions, pelvic EBRT central shield 10 5 IGBT 18 3 fractions prescribed to point A. Cumulative doses were calculated as total equivalent dose 2 (EQD2). The median follow-up was 31 (3-52) months. 2-year...