A5100377095- Botulinum Toxin and Related Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Parkinson's Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Neurological disorders and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Nerve Disorders
- Myofascial pain diagnosis and treatment
- Dementia and Cognitive Impairment Research
- Genetic Neurodegenerative Diseases
- Neurosurgical Procedures and Complications
- Alzheimer's disease research and treatments
- Cancer, Lipids, and Metabolism
- Biomarkers in Disease Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Autoimmune Neurological Disorders and Treatments
- Signaling Pathways in Disease
- Metabolism and Genetic Disorders
- Ophthalmology and Visual Impairment Studies
- Facial Nerve Paralysis Treatment and Research
- Neurofibromatosis and Schwannoma Cases
- Cancer Mechanisms and Therapy
Soochow University
2025
First Affiliated Hospital of Soochow University
2025
Zunyi Medical University
2022-2024
Beijing Tian Tan Hospital
2024
Capital Medical University
2024
National Clinical Research Center for Digestive Diseases
2024
First Affiliated Hospital of Zhengzhou University
2020-2024
Shanxi Medical University
2024
Hebei Medical University
2022-2023
Qingdao University
2021-2023
Background and Purpose: Aneurysmal wall enhancement (AWE) on vessel magnetic resonance imaging (VW-MRI) has been described as a new biomarker of unstable unruptured intracranial aneurysms (UIAs). Previous studies symptomatic UIAs are limited due to small sample sizes lack AWE quantification. Our study aims investigate whether qualitative quantitative assessment can differentiate asymptomatic UIAs. Methods: Consecutive patients with were prospectively recruited for at 3T from October 2014...
The development of castration-resistant prostate cancer (CRPC) remains a major obstacle in the treatment (PCa). Dysregulated mitochondrial function has been linked to initiation and progression diverse human cancers. Deciphering novel molecular mechanisms underlying may provide important insights for developing therapeutics CRPC.We investigate expression protein tyrosine phosphatase receptor type F polypeptide interacting alpha 4 (PPFIA4) using public datasets tumor specimens from PCa cases...
Background Cerebral amyloid angiopathy (CAA) causes cognitive decline, but it is not known whether associated with neuropsychiatric symptoms (NPS). Methods and Results Participants CAA, mild impairment, dementia due to Alzheimer's disease, normal cognition were recruited from stroke clinics community advertising. NPS captured using the Neuropsychiatric Inventory Questionnaire short form. The number total severity (number multiplied by of each symptom [mild, moderate, or severe]) analyzed...
The aim of this study was to explore the effects rosiglitazone (RSG) in combination with all-trans retinoic acid (ATRA) on proliferation and apoptosis HCT-15 human colorectal cancer cell line. cells were divided into a blank control group, vehicle group experimental groups (RSG only or ATRA RSG plus ATRA). Growth inhibition examined using MTT assay. Apoptosis cycle progression by flow cytometry. expression COX-2, MMP-7 TIMP-1 immunocytochemistry. alone inhibited concentration- time-dependent...
The overall distribution pattern of intramuscular nerves and the regions with highest spindle abundance in deep cervical muscles have not been revealed. This study aimed to reveal neuromuscular compartmentalization localize body surface position depth center region muscle (CRHMSA) muscles. included 36 adult cadavers (57.7 ± 11.5 years). curved line joining lowest point jugular notch chin tip was designated as longitudinal reference (line L), connecting acromion horizontal H). Modified...
Abstract Introduction Parkinson's (PD) is a common degenerative disease of the central nervous system. It affects more than 6 million individuals worldwide. The typical clinical manifestations include static tremor, slow movement, and unstable posture. However, correlation between head tremor severity PD remains unclear. Methods In current study, 18 patients healthy subjects were recruited to undergo phonation test. Noldus facereader 7.0 software was used analyze range trembling two groups....
Abstract The innervation of the pelvic wall muscles is not very clear. This study aimed to reveal division neuromuscular compartments and localize surface position depth center intramuscular nerve-dense region (CINDR) based on Sihler's staining. Twenty-four adult cadavers were used. To CINDR muscles, horizontal (H) longitudinal (L) reference lines drawn, Sihler’s staining was used nerve distribution. projection points (P P′ points) behind in front body surface, positions P projected onto H L...
Abstract The centre of the highest region muscle spindle abundance (CHRMSA) in intramuscular nerve‐dense has been suggested as optimal target location for injecting botulinum toxin A to block spasms. anterior forearm muscles have a high incidence spasticity. However, CHRMSA group not defined. This study aimed accurately define body surface position and depth an muscles. Twenty‐four adult cadavers (57.7 ± 11.5 years) were included this study. curved line close skin connecting medial lateral...
Purpose This study aimed to determine the body surface puncture position and depth of center intramuscular nerve dense region in suboccipital muscle provide morphological guidance for accurate botulinum toxin A injection treat headaches caused by increased tension. Methods Twenty-four cadavers aged 66.5 ± 5.3 years were studied. The curve line connecting occipital eminence or mastoid process spinous 7th cervical vertebrae was considered longitudinal reference (L) horizontal (H),...
The aim of this study was to evaluate the validity model that could produce reproducible and persistent motor weakness define accurate tasks testing parameters for longitudinal assessment neurological deficits after traumatic brain injury (TBI). We compared effects two rat models suffered different controlled cortical impact (CCI) injury, as well extensive cortex resection model, on behavior recovery morphology. Behavioral tests including skilled reaching task, limb-use asymmetry test...
Cervical dystonia (CD) is a hypertonic condition caused by damage to the central nervous system. Very few studies have assessed overall economic burden of disease. The objective this study was describe utilization health care resources patients with CD in UK primary setting, using large population-based database.Adults first diagnosis between January 1, 2007 and 31, 2011, who were registered general practitioner (GP) practice contributing Health Improvement Network (THIN), included....
Several clinical and demographic factors relate to anatomic spread of adult-onset isolated dystonia, but a predictive model is still lacking. The aims this study were: (i) develop validate dystonia; (ii) evaluate whether presence tremor associated with dystonia influences predictions spread.Adult-onset participants focal onset from the Dystonia Coalition Natural History Project database were included. We developed two prediction models, one as sole disease manifestation ("dystonia-only")...
The interaction between inflammatory biomarkers (high-sensitivity C-reactive protein, hsCRP) and antioxidants (uric acid, UA) regarding prognosis after ischemic stroke or transient attack (TIA) remains inadequately explored. This study aimed to assess (1) the individual joint effects of hsCRP UA, (2) neuroprotective role UA in patients with elevated levels concerning poor functional outcomes at 90 days. A prospective cohort was conducted involving 2140 consecutive TIA levels. primary outcome...
Objective: To explore the effects of surgical treatment for myasthenia gravis as well its influencing factors. Methods: A total 180 patients with who underwent thymectomy from August 2012 to September 2018 were enrolled. Clinical data such age, gender, disease classification, preoperative AChR-Ab, course, operation time, intraoperative blood loss, and pathological type was retrospectively reviewed. Univariate analysis Cox regression model used analyze possible factors effects. Results: 145...