A5042260276- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Innovations in Medical Education
- Intensive Care Unit Cognitive Disorders
- Noise Effects and Management
- Education and Critical Thinking Development
- Cardiac Arrest and Resuscitation
- Ultrasound in Clinical Applications
- Pulmonary Hypertension Research and Treatments
- Tracheal and airway disorders
- Empathy and Medical Education
- Lung Cancer Diagnosis and Treatment
- Engineering Education and Curriculum Development
- Chemical and Physical Studies
- Respiratory and Cough-Related Research
- Family and Patient Care in Intensive Care Units
- Problem and Project Based Learning
- Erythrocyte Function and Pathophysiology
- Advanced MRI Techniques and Applications
- Asthma and respiratory diseases
- Clinical Reasoning and Diagnostic Skills
- Reflective Practices in Education
- High Altitude and Hypoxia
- Thermal Regulation in Medicine
Carilion Clinic
2018-2023
Virginia Tech
2018-2023
Harvard University
2001-2022
University of South Carolina
2013-2017
Prisma Health
2015
At Bristol
2011
University of New England
2007
VA Boston Healthcare System
2003
Beth Israel Deaconess Medical Center
2002
Newcastle University
1998
Issue: Calls to change medical education have been frequent, persistent, and generally limited alterations in content or structural re-organization. Self-imposed barriers prevented adoption of more radical pedagogical approaches, so recent predictions the 'inevitability' transitioning online delivery seemed unlikely. Then March 2020 COVID-19 pandemic forced schools overcome established overnight make most rapid curricular shift education's history. We share collated reports nine postulate...
Anecdotal observations suggest that hypoxia does not elicit dyspnea. An opposing view is any stimulus to medullary respiratory centers generates dyspnea via “corollary discharge” higher centers; absence of during low inspired Po 2 may result from increased ventilation and hypocapnia. We hypothesized that, with fixed ventilation, hypercapnia generate equal when matched by ventilatory drive. Steady-state levels hypoxic normocapnia (end-tidal = 60–40 Torr) hypercapnic hyperoxia Pco 40–50 were...
Hypoxia increases cerebral blood flow (CBF), but it is unknown whether this increase uniform across all brain regions. We used H(2)(15)O positron emission tomography imaging to measure absolute in 50 regions of interest the human (n = 5) during normoxia and moderate hypoxia. Pco(2) was kept constant ( approximately 44 Torr) throughout study avoid decreases CBF associated with hypocapnia that normally occurs Breathing controlled by mechanical ventilation. During hypoxia (inspired Po(2) 70...
The sensation that develops as a long breath hold continues is what this article about. We term of an urge to breathe “air hunger.” Air hunger, primal sensation, alerts us failure meet urgent homeostatic need maintaining gas exchange. Anxiety, frustration, and fear evoked by air hunger motivate behavioral actions address the failure. unpleasantness emotional consequences make it most debilitating component clinical dyspnea, symptom associated with respiratory, cardiovascular, metabolic...
Asthma evokes several uncomfortable sensations including increased "effort to breathe" and chest "tightness." We have tested the hypotheses that "effort" "tightness" are due perception of work performed by respiratory muscles. Bronchoconstriction was induced inhaled methacholine in 15 subjects with mild asthma (FEV1/FVC baseline = 81.9% ± 5.8; bronchoconstriction 64.0% 8.6). To relieve breathing, thereby minimize activation muscle afferents motor command, were mechanically ventilated....
Breathing discomfort (dyspnea) during mechanical ventilation in the ICU may contribute to patient distress and complicate care. Assessment of nonverbal cues allow caregivers estimate breathing discomfort. This study assesses accuracy those caregiver estimates.Thirty subjects were identified from ventilated, hemodynamically stable patients special care unit Maine Medical Center. Those with impaired neurological function or too unstable waken excluded. Subjects provided a subjective score...
Mouthpieces and masks change breathing, distract the subject. Accepted non-invasive methods avoid this problem, inductive plethysmographs respiratory magnetometers, but are expensive unusable in magnetic resonance imaging (MRI) scanners. Because changes ventilation affect arterial gases, thus cerebral blood flow, measurement of breathing is desirable during many functional MRI studies. Using an old principle, we constructed inexpensive, device unaffected by fields. We adapted a simple...
Abstract Idiopathic pulmonary fibrosis ( IPF ) involves collagen deposition that results in a progressive decline lung function. This process activation of Smad2/3 by transforming growth factor TGF )‐ β and Wnt signaling pathways. Collagen Triple Helix Repeat‐Containing‐1 (Cthrc1) protein inhibits activation. To test the hypothesis Cthrc1 limits function, knockout (Cthrc1 −/− wild‐type mice WT received intratracheal injections 2.5 U/kg bleomycin or saline. Lungs were harvested after 14 days...
Air hunger is an unpleasant urge to breathe and a distressing respiratory symptom of cardiopulmonary patients. An increase in tidal volume relieves air hunger, possibly by increasing pulmonary stretch receptor cycle amplitude. The purpose this study was determine whether end-expiratory (EEV) also hunger. Six healthy volunteers (3 women, 31 +/- 4 yr old) were mechanically ventilated via mouthpiece (12 breaths/min, constant end-tidal Pco(2)) at high minute ventilation (Ve; 12 2 l/min, control)...
Introduction: Cystic fibrosis (CF) is a high-yield undergraduate medical education topic that lends itself to adaptability of content.We used CF case paired with activities deliver content in near-peer teaching session.First-year (M1) and second-year (M2) students contributed acquired knowledge protein structure obstructive lung disease, respectively, generate concept map address discussion questions.Methods: Combined groups M1 M2 reviewed prompt.For 30 minutes, they created describing...
<ns4:p>This article was migrated. The marked as recommended. Engaging medical students in pre-class preparation continues to be a challenge for integrated and student-centered curricular models. If assigned readings are too lengthy, complex or poorly aligned with the in-class expectations then student engagement is diminished, consequently so ability of engage active classroom. Although much has been published on rationale necessity materials (Parmelee Michaelsen, 2010; Ewell Rodgers, 2014;...
It is important to deliver acid-base balance concepts in the context of multiple physiological systems and metabolic processes that influence homeostasis. This activity combines interactions respiratory, gastrointestinal, renal conjunction with basic metabolism generate an integrated for first-year medical students.We developed four concise case scenarios around various presentations disturbance along five sets arterial blood gases (ABGs) different lab panels. M1 students were given class...