A5105308953- Chronic Kidney Disease and Diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Pediatric Pain Management Techniques
- Blood Pressure and Hypertension Studies
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Diabetes Management and Education
- Chronic Disease Management Strategies
- Dental Anxiety and Anesthesia Techniques
- Liver Disease and Transplantation
- Renal and Vascular Pathologies
- Nanoplatforms for cancer theranostics
- Cholesterol and Lipid Metabolism
- Cardiovascular Function and Risk Factors
- Particle Detector Development and Performance
- Renal function and acid-base balance
- Dialysis and Renal Disease Management
- Hepatitis B Virus Studies
- Renal Diseases and Glomerulopathies
- Cancer therapeutics and mechanisms
- Intensive Care Unit Cognitive Disorders
Southern Medical University
2021-2025
Nanfang Hospital
2021-2025
National Clinical Research
2024-2025
Huzhou Central Hospital
2024
Zhejiang Chinese Medical University
2024
Nanjing Medical University
2022-2024
Huzhou University
2024
Zunyi Medical University
2022-2024
Tsinghua University
2024
Kunming Medical University
2024
Abstract Background Fluid therapy is a cornerstone in the treatment of sepsis . Recently, guidelines have recommended combined administration that using crystalloids plus albumin for septic patients, but optimal timing still unclear. The objective this study was to investigate association with 28-day mortality patients sepsis. Methods We involved from Medical Information Mart Intensive Care (MIMIC)-IV database, and these were categorized into group (crystalloids alone) early combination at...
The role of statin therapy in the development kidney disease patients with type 2 diabetes mellitus (DM) remains uncertain. We aimed to determine relationships between initiation and outcomes DM.
Significance Statement Serum creatinine is not a sensitive biomarker for neonatal AKI because it confounded by maternal level, gestational age, and muscle mass. In this multicenter cohort study of 52,333 hospitalized Chinese neonates, the authors proposed serum cystatin C–related criteria (CyNA) AKI. They found that C (Cys-C) robust identifying in neonates who are at an elevated risk in-hospital mortality CyNA detects 6.5 times as many cases modified Kidney Disease Improving Global Outcomes...
The effects of acute kidney injury (AKI) on liver-related outcomes in patients with hepatitis B virus (HBV) infection remain unclear. study aimed to evaluate the association between AKI mortality and complications HBV infection. multicenter, retrospective cohort included Chinese adults from 24 regional central hospitals January 2000 December 2022. was defined as a ≥ 26.5 μmol/l increase serum creatinine concentration within 48 h, or 50% over baseline 7 days. primary outcome post-discharge...
Metabolic syndrome (MS) is an increasing public health concern because of rapid lifestyle changes. Although there have been previous studies on the prevalence MS in China, may changed with changes over last decade. To update this prevalence, we performed a cross-sectional survey among adults 18 years old across China from May 2013 to July 2014. Participants underwent questionnaires and provided blood urine samples for analysis. was defined according criteria Diabetes Society. A total 12570...
Abstract Introduction Behavior management of children during dental treatment is an important but challenging issue. As a new technique, VR has been applied in pediatric anxiety. But there no final conclusion whether reduces children's Methods The aim the study to assess effectiveness digital intervention using virtual reality (VR) helmets on anxiety, pain perception, and behavior triggered for children, as well occurrence simulator sickness local anesthesia primary teeth extraction. A total...
The efficacy of immunosuppression in the management immunoglobulin A (IgA) nephropathy remains highly controversial. study was conducted to assess effect immunosuppression, compared with supportive care, real-world setting IgA nephropathy.
Rosuvastatin and atorvastatin are the most widely prescribed moderate- to high-intensity statins. However, evidence on their efficacy safety during actual use is limited.
Abstract B7-H4, a member of B7 family, is transmembrane protein that inhibits T cell immunity. It overexpressed in various malignancies, including breast, ovarian, and endometrial cancers, as well cholangiocarcinoma, where it has been associated with tumor progression poor patient outcomes. Antibody-drug conjugates (ADC) targeting B7-H4 have demonstrated promising clinical activity. Here, we present the development preclinical characterization MHB009C, novel ADC. MHB009C comprises human IgG1...
Abstract Prostate-specific membrane antigen (PSMA), a type II transmembrane glycoprotein, is highly and specifically expressed in prostate cancer while showing limited expression normal tissues. The FDA’s approval of (177) Lu-PSMA-617 has validated PSMA as therapeutic target for treating metastatic castration-resistant (mCRPC). Here, we present the development preclinical characterization MHB048C, novel specific antibody-drug conjugate (ADC). MHB048C comprises human IgG1 antibody against...
Cardiovascular-kidney-metabolic (CKM) syndrome affects a significant portion of the general population. Urinary albumin-to-creatinine ratio (UACR) is an important indicator kidney injury. While some studies have indicated associations between UACR within normal range and mortality outcomes, it remains uncertain whether traditionally could help to distinguish prognosis CKM patients. This cohort study included patients with at stages 2 3 from China Renal Data System (CRDS) UK Biobank (UKB)...
5051 Background: MHB088C is a novel B7-H3-targeted antibody-drug conjugate (ADC) incorporating the potent SuperTopoi payload, which 5 to 10 times more than Dxd. Early data from an ongoing phase 1/2 study have shown that generally well tolerated, with early signs of clinical activity (ASCO 2024, abstract #3012). Here, we present preliminary findings subset pts mCRPC. Methods: This consisted 2 parts: dose-escalation (part 1) and expansion 2). Part 1 evaluated safety tolerability at doses...
Metabolic syndrome(MetS) and depression are independently associated with type 2 diabetes (T2DM) risk. However, little is known about the combined effect of MetS on risk T2DM. The present study aims to prospectively explore impact T2DM susceptibility among Chinese general population. 6489 population without adults in Southwest China were recruited from 2010 2012. Depression assessed using a 9-item Patient Health Questionnaire(PHQ-9) Guideline for prevention treatment mellitus (2020 edition)...
Hepatitis B virus (HBV) infection is a common cause of liver-related morbidity and mortality. Evidence suggests that angiotensin-converting enzyme inhibitors (ACEIs) angiotensin II receptor blockers (ARBs) decrease liver fibrosis, an intermediate step between injury hepatocellular carcinoma (HCC). Our aim was to investigate the association use ACEIs ARBs on incident HCC mortality among patients with HBV infection.
The diagnosis of acute myocardial infarction (AMI) using high-sensitivity cardiac troponin T (hs-cTnT) remains challenging in patients with kidney dysfunction. In this large, multicenter cohort study, a total 20 912 adults who underwent coronary angiography were included. Kidney function-specific cut-off values hs-cTnT determined to improve the specificity without sacrificing sensitivity, as compared that traditional value (14 ng/L) normal function group. diagnostic accuracy novel was...
Cardiorenal syndrome highlights the bidirectional relationship between kidney and heart dysfunction. N-terminal pro-B-type natriuretic peptide (NT-proBNP), which is gold standard biomarker in failure (HF), may be an important for chronic disease (CKD) progression. However, NT-proBNP negatively related with estimated glomerular filtration rate (eGFR). In this study, we investigated association of NT-proBNP, eGFR, progression CKD patients without HF.
Acute kidney injury (AKI) has been associated with increased risks of new-onset and worsening proteinuria. However, epidemiologic data for post-AKI proteinuria was still lacking. This study aimed to determine the incidence, risk factors clinical correlations among hospitalized patients. conducted in a multicenter cohort including patients aged 18-100 years hospital-acquired AKI (HA-AKI) at 19 medical centers throughout China. The primary outcome incidence Secondary outcomes included recovery...