A5029947945- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Treatment of Major Depression
- Optical Imaging and Spectroscopy Techniques
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pain Management and Placebo Effect
- Psychosomatic Disorders and Their Treatments
- Retinal Development and Disorders
- Bipolar Disorder and Treatment
- Attention Deficit Hyperactivity Disorder
- Visual perception and processing mechanisms
- Pain Mechanisms and Treatments
- Face Recognition and Perception
- Spatial Cognition and Navigation
- Neuroscience and Neural Engineering
- Spaceflight effects on biology
- Ultrasound Imaging and Elastography
- Pain Management and Treatment
Medical University of Vienna
2016-2024
Stanford University
2021-2024
California University of Pennsylvania
2024
University of Edinburgh
2024
Maastricht University
2024
Max Planck Institute for Human Cognitive and Brain Sciences
2024
Technical University of Denmark
2024
Materialise (Germany)
2024
Williams (United States)
2023
Thomas College
2023
Transcranial magnetic stimulation (TMS) applied to a left dorsolateral prefrontal cortex (DLPFC) area with specific connectivity profile the subgenual anterior cingulate (sgACC) has emerged as highly effective non-invasive treatment option for depression. However, antidepressant outcomes demonstrate significant variability among therapy plans and individuals. One overlooked contributing factor is individual brain state at time of treatment. In this study we used interleaved TMS-fMRI...
Finding creative solutions to difficult problems is a fundamental aspect of human culture and skill highly needed. However, the exact neural processes underlying problem solving remain unclear. Insightful tasks were shown be valid method for investigating one subcomponent creativity: Aha!-moment. insightful during remote associates task (RAT) was found elicit specific cortical activity changes. Considering strong affective components Aha!-moments, as manifested in subjectively experienced...
Abstract: Repetitive transcranial magnetic stimulation (rTMS) is an effective and evidence-based therapy for treatment-resistant major depressive disorder. A conventional course of rTMS applies 20–30 daily sessions over 4–6 weeks. The schedule delivery can be accelerated by applying multiple per day, which reduces the duration a treatment with predefined number sessions. Accelerated time demands, improves clinical efficiency, potentially induces faster onset antidepressant effects. However,...
Abstract Several previous functional magnetic resonance imaging (fMRI) studies have demonstrated the predictive value of brain activity during emotion processing for antidepressant response, with a focus on clinical outcome after 6–8 weeks. However, longitudinal emphasize paramount importance early symptom improvement course disease in major depressive disorder (MDD). We therefore aimed to assess whether neural discrimination task (EDT) predicts effects, and how these measures relate more...
Transcranial magnetic stimulation (TMS) is an FDA-approved therapeutic option for treatment resistant depression. However, exact mechanisms-of-action are not fully understood and individual responses variable. Moreover, although previously suggested, the network effects underlying TMS' efficacy poorly as of today. Although, it supposed that DLPFC indirectly modulates sgACC, recent evidence sparse.
TMS is a valuable tool in both research and clinical settings, playing crucial role understanding brain-behavior relationships providing treatment for various neurological psychiatric conditions. Importantly, over left DLPFC an FDA approved MDD. Despite its potential, response variability to remains challenge, with stimulation parameters, particularly the intensity, being primary contributor these differences.The objective of this study was establish dose-response by means concurrent...
Left prefrontal intermittent theta-burst stimulation (iTBS) has emerged as a safe and effective transcranial magnetic (TMS) treatment protocol in depression. Though network effects after iTBS have been widely studied, the deeper mechanistic understanding of target engagement is still at its beginning. Here, we investigate feasibility novel integrated TMS-fMRI setup accelerated echo planar imaging to directly observe immediate full sessions. In our effort explore interleaved iTBS-fMRI...
Despite its importance as the prime method for non-invasive assessment of human brain function, functional MRI (fMRI) was repeatedly challenged with regards to validity fMRI-derived activation maps. Amygdala fMRI particularly targeted, amygdala's anatomical position in ventral combined strong magnetic field inhomogeneities and proximity large vessels pose considerable obstacles robust mapping. In this high-resolution study performed at ultra-high (7T) fMRI, we aimed (1) investigating...
Intermittent theta burst stimulation (iTBS) of the dorsolateral prefrontal cortex (DLPFC) is widely applied as a therapeutic intervention in mental health; however, understanding its mechanisms still incomplete. Prior magnetic resonance imaging (MRI) studies have mainly used offline iTBS or short sequences concurrent transcranial (TMS)-functional MRI (fMRI). This study investigated full 600-stimuli protocol using interleaved TMS-fMRI comparison with 2 control conditions healthy subjects. In...
Abstract Major depressive disorder (MDD) has been hypothesized to lead impairments in empathy. Previous cross-sectional studies did not disentangle effects of MDD itself and antidepressant treatment. In this first longitudinal neuroimaging study on empathy depression, 29 patients with participated two functional magnetic resonance imaging (fMRI) sessions before after 3 months therapy. We compared their responses an for pain task a group healthy controls ( N = 35). All participants provided...
Diffusion-weighted imaging (DWI) is used to measure gray matter tissue density and white fiber organization/directionality. Recent studies show that DWI also allows for assessing neuroplastic adaptations in the human hypothalamus. To this end, we investigated a potential influence of testosterone replacement therapy on hypothalamic microstructure female-to-male (FtM) transgender individuals. 25 FtMs were measured at baseline, 4 weeks, months past treatment start compared female male...
Functional magnetic resonance imaging (fMRI) successfully disentangled neuronal pathophysiology of major depression (MD), but only a few fMRI studies have investigated correlates and predictors remission. Moreover, most used clinical outcome parameters from two time points, which do not optimally depict differential response times. Therefore, we aimed to detect remission in an antidepressant treatment study with 7 T fMRI, potentially harnessing advances detection power spatial specificity....
Abstract Background Studies investigating hippocampal volume changes after treatment with serotonergic antidepressants in patients major depressive disorder yielded inconsistent results, and effects on subfields are unclear. Methods To detail total subfield volumes, we conducted an open-label study escitalopram followed by venlafaxine upon nonresponse 20 unmedicated disorder. Before 12 weeks treatment, measured formation volumes ultra-high field (7 Tesla), T1-weighted, structural magnetic...
"Wernicke's area" is most often used to describe the posterior superior temporal gyrus (STG) and refers a region traditionally thought support language comprehension. However, STG additionally plays critical role in production. The purpose of current study was determine what extent regions within are selectively recruited during production.23 healthy right-handed participants completed an auditory fMRI localizer task, resting-state underwent neuronavigated TMS mapping. We applied repetitive...