A5062412347- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Biochemical effects in animals
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Antioxidants, Aging, Portulaca oleracea
- Anesthesia and Neurotoxicity Research
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
- Nerve injury and regeneration
- Circadian rhythm and melatonin
- RNA Interference and Gene Delivery
- Acupuncture Treatment Research Studies
- Medicinal Plant Extracts Effects
- Pancreatic function and diabetes
- Medicinal Plants and Neuroprotection
- MicroRNA in disease regulation
- Neuroendocrine regulation and behavior
- Genetics and Neurodevelopmental Disorders
- Heat shock proteins research
Seoul National University
2015-2024
Konkuk University Medical Center
2021
Hallym University Medical Center
2021
Chungnam National University
2021
New Generation University College
2021
Hallym University
2003-2021
Gangneung–Wonju National University
2021
National University College
2021
Seoul Institute
2018-2019
Government of the Republic of Korea
2019
Abstract: Melatonin ( N ‐acetyl‐5‐methoxytryptamine) has multiple functions. In this study, we investigated the effects of melatonin on memory, cell proliferation, and neuroblast differentiation in dentate gyrus a mouse model d ‐galactose‐induced aging. ‐galactose was subcutaneously administered to 7‐wk‐old mice for 10 wk, age‐matched were used as controls. Seven weeks after administration, vehicle (water) or (6 mg/L water) ad libitum 3 wk. The administration significantly increased escape...
Aging is a progressive process, and it may lead to the initiation of neurological diseases. In this study, we investigated effects wild Indian Curcuma longa using Morris water maze paradigm on learning spatial memory in adult D-galactose-induced aged mice. addition, cell proliferation neuroblast differentiation were assessed by immunohistochemistry for Ki67 doublecortin (DCX) respectively. The aging model mice was induced through subcutaneous administration D-galactose (100 mg/kg) 10 weeks....
The majority of immune cells in the brain are comprised microglia, which undergo morphological changes when activated to remove damaged neurons and infectious agents from tissue. In this study, we investigated effects type 2 diabetes on microglial activation subsequent secretion pro-inflammatory cytokines, such as interferon-gamma (IFN-gamma) interleukin-1beta (IL-1beta), hippocampus using Zucker diabetic fatty (ZDF) rats lean control (ZLC) at various stages.Zucker were sacrificed 12 (early...
In the present study, we investigated effects of type 2 diabetes-induced hyperglycemia on integrity blood–brain barrier and tight junction markers in rat hippocampus. Forty-week-old diabetic (Zucker fatty, ZDF) rats littermate control lean control, ZLC) were used this study. We evaluated by measuring sodium fluorescein extravasation blood vessel ultrastructure. addition, markers, such as zona occludens-1, occludin claudin-5, quantified western blot analysis. ZDF showed significantly...
Objectives: Luteolin, a common flavonoid from many plants, has various pharmacological activities, including memory-improving effect. In this study, we investigated the effects of luteolin on spatial memory, cell proliferation, and neuroblast differentiation in hippocampal dentate gyrus rat model scopolamine (SCO)-induced amnesia.Methods: Scopolamine was subcutaneously administered for 28 days via an Alzet minipump (44 mg/ml delivered at 2·5 μl/h) along with daily intraperitoneal...
Dendropanax morbifera Léveille has been employed for the treatment of infectious diseases using folk medicine. In this study, we evaluated antioxidant effects a leaf extract in hippocampus mercury-exposed rats. Seven-week-old Sprague–Dawley rats received daily intraperitoneal injection 5 μg/kg dimethylmercury and/or oral (100 mg/kg) 4 weeks. Animals were sacrificed 2 h after last treatment. Mercury levels measured homogenates hippocampal tissue, brain region that is vulnerable to mercury...
Abstract The transmembrane nerve injury-induced protein 1 (Ninjurin1 or Ninj1) is involved in progressing inflammatory diseases. In this study, we aimed to investigate a novel function of Ninj1 pulmonary fibrosis. We found that the expression patient cohort was upregulated lung specimens idiopathic fibrosis patients as well mice with bleomycin-induced addition, BLM-injected KO exhibited mild fibrotic phenotype, compared WT mice. Therefore, hypothesized would play an important role...
Dendropanax morbifera Léveille is used in herbal medicine as a cancer treatment. In this study, we investigated the effects of stem extract (DMS) on cadmium (Cd) excretion from blood and kidney brain tissues rats exposed to cadmium, well DMS oxidative stress antioxidant levels hippocampus after Cd exposure. Seven-week-old Sprague-Dawley were 2 mg/kg by intragastric gavage orally administered 100 for 4 weeks. Animals sacrificed determination was performed using inductively coupled plasma mass...
Intrathecal injection of neostigmine enhances antinociception from clonidine while it counteracts clonidine-induced hypotension. This study further examined the pharmacology neostigmine-clonidine interactions in spinal cord and focused on roles muscarinic receptor subtypes local nitric oxide synthesis. Spinal counteracted decreases blood pressure heart rate conscious sheep this effect was blocked by M2 antagonist, AFDX-116, but not M1 pirenzepine. Carbamylcholine injected spinally alone...
Previously, we observed that electroacupuncture (EA) at ST36 (Zusanli) and GV20 (Baihui) enhanced cell proliferation neuroblast differentiation in the rat dentate gyrus. In this study, investigated possible mechanisms of EA effect. For this, applied Wistar rats (13-week-old) once a day for 3 weeks. Application these acupoints significantly increased number phosphorylated cyclic AMP response element-binding protein (pCREB)-immunoreactive cells addition, levels brain-derived neurotrophic...
We compared the effects of acupuncture and electroacupuncture on cell proliferation neuroblast differentiation using specific markers, Ki67 doublecortin (DCX), in subgranular zone dentate gyrus (SZDG) 13-week old Wistar rats. Acupuncture were applied simultaneously acu-points, ST36 (Zusanli) GV20 (Baihui), once a day for 3 weeks. at these acu-points significantly increased number Ki67-positive cells DCX-immunoreactive neuroblasts to control or sham group. Electroacupuncture treatment...
Objectives:Histone deacetylases (HDACs) play a key role in synaptic plasticity and learning memory. Sirtuin 2 (SIRT2), class III HDAC, is abundantly expressed neurons functions as mitotic exit regulator dividing cells. In this study, we investigated the of SIRT2 cell proliferation neuroblast differentiation mouse dentate gyrus.Methods:To facilitate delivery into neurons, constructed PEP-1-SIRT2 fusion protein. Mice were divided three groups: vehicle (PEP-1), SIRT2, with sodium butyrate (an...
Inflammatory bowel disease (IBD) is characterized by chronic or recurrent inflammation of the gastrointestinal tract. Even though current strategies to treat IBD include anti-inflammatory drugs and immune modulators, these treatments have side-effects. New are, therefore, required overcome limitations therapies. In this study, we investigated anti-colitic effects allyl isothiocyanate (AITC), which an active ingredient present in Wasabia japonica. The DSS-induced colitis model mouse was used...