Nicholas M. Carducci

ORCID: 0000-0002-6827-9664
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About
Contact & Profiles
Research Areas
  • Retinal and Macular Surgery
  • Genetics and Neurodevelopmental Disorders
  • Ubiquitin and proteasome pathways
  • Glaucoma and retinal disorders
  • Intraocular Surgery and Lenses
  • Retinal and Optic Conditions
  • Mitochondrial Function and Pathology
  • Orthopedic Surgery and Rehabilitation
  • Surgical Sutures and Adhesives
  • Pregnancy and preeclampsia studies
  • Cellular transport and secretion
  • Neurological Complications and Syndromes
  • Shoulder Injury and Treatment
  • Blood disorders and treatments
  • Intraoperative Neuromonitoring and Anesthetic Effects
  • Orthopedic Infections and Treatments
  • Surgical site infection prevention
  • Birth, Development, and Health
  • Autism Spectrum Disorder Research
  • Autoimmune Neurological Disorders and Treatments
  • Elbow and Forearm Trauma Treatment

University of Michigan
2014-2023

University of Pennsylvania
2016-2018

Penn Presbyterian Medical Center
2018

The FMR1 protein product, FMRP, is an mRNA binding associated with translational inhibition of target transcripts. One FMRP the amyloid precursor (APP) mRNA, and APP levels are elevated in Fmr1 KO mice. Given that expression can elicit Alzheimer's disease (AD) patients model systems, we evaluated whether might be altered autopsy brain samples mouse models compared to controls. In a double transgenic AD (APP/PS1), found no difference aged mice littermate was also similar control patient...

10.3389/fgene.2014.00360 article EN cc-by Frontiers in Genetics 2014-10-21

Purpose: To describe early structural and functional retinal changes in a patient with Cohen syndrome.Methods: A 13-month-old Caucasian girl of Irish Spanish ancestry was noted to have micrognathia laryngomalacia at birth, which prompted genetic evaluation that revealed biallelic deletions COH1 (VPS13B) (a maternally inherited 60-kb deletion involving exons 26–32 paternally 3.5-kb within exon 17) consistent syndrome. She underwent complete ophthalmic examination, full-field flash...

10.1080/13816810.2018.1459735 article EN Ophthalmic Genetics 2018-04-10

To investigate the clinical features and surgical outcomes of rhegmatogenous retinal detachment (RRD) associated with giant tears (GRTs) at a tertiary referral center.A retrospective, non-consecutive interventional case series GRT-associated RRDs that underwent primary repair University Michigan W.K. Kellogg Eye Center between January 1, 2011 July 2020. Clinical characteristics preoperative, perioperative, postoperative data were collected.Forty-eight eyes 47 patients met inclusion criteria,...

10.2147/opth.s299762 article EN cc-by-nc Clinical ophthalmology 2021-03-01

To investigate the effect of coronavirus disease 2019 (COVID-19) lockdown on presentation and management acute, primary rhegmatogenous retinal detachment (RRD).This was a single-center, consecutive case series with historic controls, examining patients during COVID-19 "stay-at-home" order (March 24 to June 1, 2020), subsequent reopening phase (June 1 July 31, corresponding preceding intervals 2016 2019).Despite significant increase in presenting macula-off RRD compared timeframe (P = .03),...

10.3928/23258160-20211015-01 article EN Ophthalmic surgery, lasers & imaging retina 2021-11-01

Purpose: To describe a novel case of focal exudative retinal detachment, choroidal effusion, and acute angle closure in preeclampsia. Methods: A report is presented. Results: 37-year-old woman at 38 weeks gestation presented with 2 progressive blurred vision the left eye. She had visual acuity (VA) 20/800 an intraocular pressure (IOP) 26 mm Hg eye (compared 17 right eye). Examination showed subretinal fluid posterior pole, ciliochoroidal without pathology was found to have hypertension...

10.1177/24741264221147986 article EN Journal of VitreoRetinal Diseases 2023-02-17
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