Environmental protection and environmental sustainability are becoming increasingly important factors in the hotel business their competitiveness, a market that brings numerous benefits. is, increasingly, considered one of most functions business, as well communication marketing, which attracts larger number guests. Some key aspects performance indicators, management order to establish efficiency process. The principal question arising is how environmentally sustainable affects performance,...

Drug release from hydrophilic matrix tablets can be strongly influenced by the proportion of forming polymer and dimensions geometry tablets. A complete two-factor, three-level factorial design, followed multiple regression analysis response surface methodology, was applied to investigate influence level tablet size on drug kinetics prepared with Carbopol 971P 71G. Tablet diameter, radius-to-height ratio, area, surface-area-to-volume ratio were evaluated as independent variables in terms...

Abstract Paracetamol is a widely used nonsalicylate analgesic and antipyretic drug. The existing methods for the determination of paracetamol in biological fluids are mainly HPLC techniques, although there some reported based on spectrophotometric determinations. However, all these involve extraction or derivatisation procedures. In present study UV spectra investigated samples were recorded over wavelength range 220–400 nm ( λ step 0.21 nm; scan speed 60 nm/min) second‐order derivative...

The influence of dissolution media composition on drug release kinetics and in-vitro/in-vivo correlation (IVIVC) for hydrophilic matrix tablets based Carbopol 971P 71G was investigated. A number buffered unbuffered differing with respect to their pH value, ionic strength species evaluated. observed in-vitro profiles were compared the hypothetical in-vivo calculated by numerical deconvolution from results an study. obtained IVIVC plots examined using linear non-linear (proportional odds,...

The aim of this study was to investigate the usefulness combined application quality by design tools such as central composite (CCD), response surface methodology (RSM), and artificial neural networks (ANN) in characterization, modeling, optimizaton spray drying a poorly soluble drug : cyclodextrin complex. Models were developed RSM ANN from different pools data. model with best predictability multilayer perceptron (MLP)1 largest group data (R 2 for yield 0.854, moisture content 0.886). On...

The main objective of this study was to develop a mathematical model for the characterization diclofenac sodium diffusion from polyethylene oxide (PEO) matrices. A developed on basis theory accounting characteristics polymer: swelling with subsequent dissolution in water. concentration-dependent drug and water taken into account. Experimental data were analysed using computer software program as an aid solving partial differential equations.Six formulations matrix tablets different...

The primary and most significant component of all activities in modern global civilization is environmental protection. Its endangerment as a result rapid economic technical advancement increasingly becoming an ecological crisis danger to the continued existence life on Earth. Synergy at levels figuring out how implement attain high level quality, actual challenge facing contemporary society. A planned, integrated, holistic systemic approach through determinants sustainable management...

Sustainable development is a multidimensional term becoming increasingly important in modern business conditions and one of the primary issues scholarly debate. built on three interwoven pillars: economic, social, ecological. The economic pillar relates to decrease negative consequences economies scale, as well its reduced environmental imprint. social dimension sustainability based justice quality human life. ecological dimension, which most significant, refers maximum protection natural...

Environmental protection is of exceptional importance for the development tourism due to mutual links between and environment, as well growing trend among tourists choose travel destinations accommodation facilities that apply principles environmental sustainable development. Tourism, besides its positive effects, has a largely negative impact on environment. Governments, local communities all companies in industry should, therefore, show their social responsibility actively participate...

ObjectivesThe main objective of this study was to develop a mathematical model for the characterization diclofenac sodium diffusion from polyethylene oxide (PEO) matrices. A developed on basis theory accounting characteristics polymer: swelling with subsequent dissolution in water. The concentration-dependent drug and water taken into account. Experimental data were analysed using computer software program as an aid solving partial differential equations.