A5035174091- Vagus Nerve Stimulation Research
- Neurological Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Intracerebral and Subarachnoid Hemorrhage Research
- Kruppel-like factors research
- Neurological Disorders and Treatments
- Alzheimer's disease research and treatments
- Diet and metabolism studies
- Iron Metabolism and Disorders
- Stress Responses and Cortisol
- Dietary Effects on Health
- Cardiovascular Function and Risk Factors
- Metabolomics and Mass Spectrometry Studies
- Health, psychology, and well-being
- MicroRNA in disease regulation
- Childhood Cancer Survivors' Quality of Life
- Immune Cell Function and Interaction
- Gastrointestinal motility and disorders
- Hemoglobinopathies and Related Disorders
- Emergency and Acute Care Studies
- Cannabis and Cannabinoid Research
- Schizophrenia research and treatment
- Prenatal Substance Exposure Effects
- Cardiovascular and exercise physiology
- Memory and Neural Mechanisms
Penn State Milton S. Hershey Medical Center
2023-2024
University of Colorado Boulder
2019-2023
The Timeline Followback (TLFB) was originally developed to assess alcohol consumption patterns (American Journal of Public Health, 86, 1996, 966) and has been increasingly modified for Web-based use. Additionally, new modes substance use administration have emerged, creating a need an adaptable TLFB tool than can capture data such as cannabis product potency or prescription drug Our goal validate online that reliably assesses wide range substances in greater detail.Using within-subjects...
INTRODUCTION: Intracerebral hemorrhage (ICH) is a devastating disease with 30-day mortality rate greater than 40%. Following hemorrhage, iron released from blood-breakdown leads to an iron-dependent form of cell-death known as ferroptosis. Animal studies on genetic variations in metabolism demonstrate that the H67D HFE mutation reduces ICH-associated However, impact commonly found human homolog, H63D mutation, has not been studied stroke patients. METHODS: Four different machine learning...
Emerging research suggests that one mechanism through which physical activity may decrease cancer risk is its influence on the methylation of genes associated with cancer. The purpose current study was to prospectively test, using a rigorous experimental design, whether aerobic exercise affects DNA in breast cancer, as well quantity completed change dose-response manner. 276 women (M age = 37.25, SD 4.64) were recruited from Denver metro area for randomized controlled trial participants...
Intracerebral hemorrhage (ICH) is characterized by bleeding into the brain parenchyma. During an ICH, iron released from breakdown of hemoglobin creates a cytotoxic environment in through increased oxidative stress. Interestingly, loss homeostasis associated with pathological process other neurological diseases. However, we have previously shown that H63D mutation homeostatic regulatory (
Abstract Adequate and timely delivery of iron is essential for brain development. The uptake transferrin‐bound (Tf) into the peaks at time myelination, whereas recently discovered H‐ferritin (FTH1) transport continues to increase beyond peak in myelination. Here, we interrogate impact dietary deficiency (ID) on FTH1‐ Tf‐bound iron. In present study, used C57BL/6J male female mice a developing (post‐natal day (PND) 15) adult age (PND 85). mice, ID results increased from both FTH1 Tf males...
This study utilized a randomized control trial to examine whether structural changes in the precuneus, insula, caudate, hippocampus, and putamen were related exercise. A total of 197 healthy older adults with no evidence dementia participated moderate-intensity interval training or low-intensity continuous for 16 weeks. Size decreased right hippocampus such that effect time was significant but interaction condition not. For left size increased plus at trend level. Finally, there...
Maximal aerobic exercise capacity [maximal oxygen consumption (V̇o
INTRODUCTION: Intracerebral hemorrhage (ICH) is a devastating disease with one-year mortality rate of 45%. In the setting an ICH, breakdown blood releases iron into brain parenchyma. This excess contributes to stroke-induced neurodegeneration as it creates cytotoxic environment through increased oxidative stress. Genetic variations in metabolism such H63D HFE mutation have been shown modify progression neurodegenerative diseases Parkinson’s, but not studied ICH. METHODS: An autologous...
Abstract Glioblastoma (GBM) is an aggressive brain cancer that sexually dimorphic in nature, with females less susceptible to developing it, responding better therapy, and gaining a survival advantage. Iron metabolism also has been shown previously contribute sex bias GBM. Ferritin iron-storing protein elevated expression tumor cells essential GBM growth. Here, we used vivo model consisting of heterozygous FTH1 knockdown (FTH1-KD) mice GL261 study the role host ferritin progression. We have...