A5079955860- Analytical Methods in Pharmaceuticals
- Advanced Drug Delivery Systems
- Analytical Chemistry and Chromatography
- Synthesis and biological activity
- Antibiotics Pharmacokinetics and Efficacy
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Synthesis and Reactivity of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Diabetes Treatment and Management
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Nanoparticle-Based Drug Delivery
- Synthesis and bioactivity of alkaloids
- Pesticide Residue Analysis and Safety
- Pharmacological Effects of Natural Compounds
- Electrochemical sensors and biosensors
- Analytical Chemistry and Sensors
- Inhalation and Respiratory Drug Delivery
- Synthesis and Reactions of Organic Compounds
- Multicomponent Synthesis of Heterocycles
- Inflammatory mediators and NSAID effects
- Pharmaceutical studies and practices
King Faisal University
2016-2025
Pharmaceutical Biotechnology (Czechia)
2022
Al-Ameen College of Pharmacy
2004-2007
Curcumin, an organic phenolic molecule that is extracted from the rhizomes of Curcuma longa Linn, has undergone extensive evaluation for its diverse biological activities in both animals and humans. Despite favorable characteristics, curcumin encounters various formulation challenges stability issues can be effectively addressed through application nanotechnology. Nano-based techniques specifically focused on enhancing solubility, bioavailability, therapeutic efficacy while mitigating...
Analysis of pharmaceutical and natural compounds newer drugs is commonly used in all the stages drug discovery development process. High-performance thin layer chromatography one sophisticated instrumental techniques based on full capabilities chromatography. The advantages automation, scanning, optimization, selective detection principle, minimum sample preparation, hyphenation, so enable it to be a powerful analytical tool for chromatographic information complex mixtures pharmaceuticals,...
Solid lipid nanoparticles (SLNs) are being extensively exploited as topical ocular carrier systems to enhance the bioavailability of drugs. This study investigated prospects drug-loaded SLNs increase permeation and improve therapeutic potential clarithromycin in therapy. were formulated by high-speed stirring ultra-sonication method. Solubility studies carried out select stearic acid former, Tween 80 surfactant, Transcutol P cosurfactant. Clarithromycin-loaded SLN optimized fractional...
In situ gels have been extensively explored as ocular drug delivery system to enhance bioavailability and efficacy. The objective of present study was design, formulate evaluate ion-activated in gel the penetration therapeutic performance moxifloxacin ophthalmic delivery. A simplex lattice design utilized examine effect various factors on experimental outcomes system. influence polymers (independent variables) such gellan gum (X 1 ), sodium alginate 2 HPMC 3 ) strength, adhesive force,...
Water quality is under constant threat worldwide due to the discharge of heavy metals into water from industrial waste. In this report, we introduce a potential candidate, chitosan, extracted and isolated shrimp shells, that can adsorb polluted water. The waste shell chitosan was characterized via Fourier transform infrared spectroscopy (FTIR) scanning electron microscopy with energy dispersive X-ray (SEM-EDS). adsorption capacity on modified measured using an inductively coupled plasma mass...
Assessing the bioavailability of drug molecules at site action provides better insight into efficiency a dosage form. However, determining concentration in skin layers following topical application dermatological formulations is great challenge. The protocols followed oral could not be applied for forms. regulatory agencies are considering several possible approaches such as tape stripping, microdialysis etc. On other hand, assessment xenobiotics equally important order to evaluate toxicity....
The therapeutic potential of acyclovir is limited by the low oral bioavailability owing to its aqueous solubility and permeability. present study was a systematic investigation on development evaluation inclusion complex using hydroxypropyl-β-cyclodextrin for enhancement acyclovir. prepared kneading method drug: (1:1 mole). characterized Fourier transform infrared spectroscopy, differential scanning calorimetry, NMR spectroscopy evaluated in vitro dissolution studies. In vivo compared...
Transdermal delivery of insulin is a great challenge due to its poor permeability through the skin. The aim current investigation was evaluate prospective loaded niosome emulgel as noninvasive system for transdermal therapy. A 23 full-factorial design used optimize by assessing effect independent variables (concentration paraffin oil, Tween 80 and sodium carboxymethyl cellulose) on dependent (in vitro release, viscosity in permeation). physical characteristics prepared formulations were...
The present study is a mechanistic validation of ‘proof-of-technology’ for the effective topical delivery chrysin nanoemulgel localized, efficient treatment melanoma-affected skin. Background: Currently available treatments skin cancer are inefficient due to systemic side effects and poor transcutaneous permeation, thereby presenting formidable challenge development novel nanocarriers. Methods: We opted approach formulated nanocomplex system composed hydrophobic dissolved in lipid mix, which...
The clinical efficacy of antiretroviral therapy in NeuroAIDS is primarily limited by the low perfusion drug to brain. objective current investigation was design and develop an situ mucoadhesive gel loaded with darunavir assess feasibility brain targeting through intranasal route. Preliminary batches (F1−F9) were prepared evaluated for various pharmaceutical characteristics. A full factorial experiment applied optimize effect two influencing variables (Carbopol 934P (X1) Poloxamer 407 (X2))...
Being a biopharmaceutics classification system class II drug, the absorption of sertraline from gut is mainly limited by its poor aqueous solubility. The objective this investigation was to improve solubility utilizing self-nanoemulsifying drug delivery systems (SNEDDS) and developing it into tablet dosage form. Ternary phase diagrams were created identify nanoemulsion regions fixing oil (glycerol triacetate) water while varying surfactant (Tween 80) co-surfactant (PEG 200) ratio (Smix). A...
The 4-allyl guaiacol is a natural phenolic molecule that has been widely studied for its antioxidant capacity against reactive-oxygen-species-mediated cellular damage. Therefore, we hypothesized concomitant use of an and NSAID may decrease the risk gastrointestinal toxicity make therapy safer. To address conventional NSAIDs, new S-naproxen-4-allyl chimera (MAS-1696) was computationally developed, chemically synthesized, tested anti-inflammatory effectiveness safety. inhibitory potency...
Benzothiazole derivatives are known for anti-TB properties. Based on the benzothiazole pharmacophore, in present study, we described synthesis, structural elucidation, and anti-tubercular screening of a series novel (BNTZ) (BNTZ 1-7 BNTZ 8-13).The study aims to carry out development based compounds.Title compounds synthesized by microwave method purified column chromatography. Characterization is achieved FT-IR, NMR (1H 13C), LCMS elemental analysis. Screening test activity Resazurin...
Poor peroral therapeutic efficiency of selegiline is primarily due to the extensive hepatic metabolism and hence need for an alternative route administration. The present study based on evaluation a buccal film which impregnated with nanospheres enhance systemic bioavailability. Selegiline-loaded prepared using poly(lactide-co-glycolide) was embedded into films (F1-F4) varying polymer composition [hydroxypropyl methylcellulose eudragit]. developed were evaluated their physicomechanical...
Thiazole and benzothiazole derivatives, as well thiazolidinones are very important scaffolds in medicinal chemistry. Literature has revealed that they possess a wide spectrum of biological activities including antimicrobial activity.The goal this paper is the designing new based evaluation their activities.The designed compounds were synthesized using classical organic synthesis methods. The activity was evaluated method microdilution.The twelve newly showed properties. All appeared to be...
Abstract: Diabetes is considered one of the main threats to global public health in this era. It increasing rapidly every part world; prevalence disease will grow point where 366 million people be affected by 2030. The diabetes mellitus (DM) Saudi population high, and majority patients suffer from type 2 DM. Marketed oral antidiabetic drugs have indicated poor tolerability during chronic treatments, contributes moderately large proportion DM that remain inadequately managed. Vildagliptin...
Selective targeting of anticancer drugs to the tumor site is beneficial in pharmacotherapy hepatocellular carcinoma (HCC). This study evaluated prospective galactosylated chitosan nanoparticles as a liver-specific carrier improve therapeutic efficacy gemcitabine HCC by asialoglycoprotein receptors expressed on hepatocytes. Nanoparticles were formulated (G1–G5) an ionic gelation method and for various physicochemical characteristics. Targeting formulation G4 was rats. Physicochemical...
A series of trisubstituted indolizine analogues has been designed as a result fragment-based approach to target the inhibition mycobacterial enoyl-acyl carrier protein reductase. Anti-tuberculosis (TB) screening characterized compounds by resazurin microplate assay method revealed that ethyl group at second position nucleus exhibited activity against susceptible and multidrug-resistant strains Mycobacterium tuberculosis concentration 5.5 11.3 μg/mL, respectively. molecular docking study was...
A series of ethyl 1-(substituted benzoyl)-5-methylpyrrolo[1,2-a]quinoline-3-carboxylates 4a–f and dimethyl benzoyl)-5-methylpyrrolo[1,2-a]quinoline-2,3-dicarboxylates 4g–k have been synthesized evaluated for their anti-tubercular (TB) activities against H37Rv (American Type Culture Collection (ATCC) strain 25177) multidrug-resistant (MDR) strains Mycobacterium tuberculosis by resazurin microplate assay (REMA). Molecular target identification these compounds was also carried out a...