A5011098931- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Characterization of Heterocyclic Compounds
- Crystal structures of chemical compounds
- Synthesis and Reactivity of Heterocycles
- Multicomponent Synthesis of Heterocycles
- Crystallography and molecular interactions
- Synthesis and Biological Evaluation
- Analytical Methods in Pharmaceuticals
- Cancer therapeutics and mechanisms
- Quinazolinone synthesis and applications
- Advanced Drug Delivery Systems
- Synthesis and Reactions of Organic Compounds
- Analytical Chemistry and Chromatography
- Computational Drug Discovery Methods
- Essential Oils and Antimicrobial Activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis of Organic Compounds
- Click Chemistry and Applications
- Inflammatory mediators and NSAID effects
- Advancements in Transdermal Drug Delivery
- Tuberculosis Research and Epidemiology
- Synthesis and bioactivity of alkaloids
- Diabetes Treatment and Management
Durban University of Technology
2016-2025
King Faisal University
2016-2025
Pharmaceutical Biotechnology (Czechia)
2016-2022
Hebrew University of Jerusalem
2019
Faculty (United Kingdom)
2018
University of KwaZulu-Natal
2009-2013
Bangalore University
2013
Indian Institute of Science Bangalore
2004-2011
University of Mysore
2010
Al-Ameen College of Pharmacy
2003-2009
Following the discovery of SARS-CoV-2 Omicron variant (B.1.1.529), global COVID-19 outbreak has resurfaced after appearing to be relentlessly spreading over past 2 years. This new showed marked degree mutation, compared with previous variants. study investigates evolutionary links between and recently emerged The entire genome sequences variants were obtained, aligned using Clustal Omega, pairwise comparison was computed, differences, identity percent, gaps, mutations noted, matrix...
Tissue repair and wound healing are complex processes that involve inflammation, granulation, remodeling of the tissue. The potential various statins including atorvastatin (ATR) to improve effect was established. aim this study formulate evaluate efficacy topical application ATR-based nanoemulgel on healing. prepared formulations (ATR gel, ATR emulgel, nanoemulgel) were evaluated for their physical appearance, rheological behavior, in vitro drug release ex vivo permeation. wound-induced...
The potential role of naringenin (NAR), a natural flavonoid, in the treatment chronic wound has prompted present research to deliver drug nanoemulsion (NE) form, where synergistic chitosan was achieved through development chitosan-coated NAR NE (CNNE). consisted Capryol 90, Tween 20 and Transcutol P, which fabricated by low-energy emulsification method encapsulate within oil core. optimization formulated NEs performed using Box-Behnken statistical design obtain crucial variable parameters...
SARS-CoV-2 or Coronavirus disease 19 (COVID-19) is a rapidly spreading, highly contagious, and sometimes fatal for which drug discovery vaccine development are critical. papain-like protease (PLpro) was used to virtually screen 1697 clinical FDA-approved drugs. Among the top results expected bind with PLpro strongly were three cell protectives antioxidants (NAD+, quercitrin, oxiglutatione), antivirals (ritonavir, moroxydine, zanamivir), two antimicrobials (doripenem sulfaguanidine),...
Solid lipid nanoparticles (SLNs) are being extensively exploited as topical ocular carrier systems to enhance the bioavailability of drugs. This study investigated prospects drug-loaded SLNs increase permeation and improve therapeutic potential clarithromycin in therapy. were formulated by high-speed stirring ultra-sonication method. Solubility studies carried out select stearic acid former, Tween 80 surfactant, Transcutol P cosurfactant. Clarithromycin-loaded SLN optimized fractional...
The burden of antibiotic resistance necessitates a continued search for new antimicrobials. We evaluated the antimicrobial activities novel benzothiazoles synthesized by our group. Antibacterial activity was in vitro Staphylococcus aureus, Bacillus subtilis, and Escherichia coli, while antifungal tested Candida albicans Aspergillus niger, expressed as minimum inhibitory concentration (MIC; µg/mL). MIC values benzothiazole compounds ranged from 25 to 200 µg/mL. Compounds 3 4 gave high...
In situ gels have been extensively explored as ocular drug delivery system to enhance bioavailability and efficacy. The objective of present study was design, formulate evaluate ion-activated in gel the penetration therapeutic performance moxifloxacin ophthalmic delivery. A simplex lattice design utilized examine effect various factors on experimental outcomes system. influence polymers (independent variables) such gellan gum (X 1 ), sodium alginate 2 HPMC 3 ) strength, adhesive force,...
Polycystic ovary syndrome (PCOS) is the most common gynaecological endocrine disease that causes anovulatory infertility. The current study aimed to explore possible role of diacerein (DIA), an IL-1β inhibitor, in treating letrozole-induced PCOS rats exhibit metabolic and endocrinal criteria patients. was induced female Wistar by oral administration letrozole (1 mg/kg, per orally, p.o.) for 21 days. Rats were then treated with DIA (25 mg/kg/day, p.o.), (50 or metformin (2 mg/100 g/day, 14...
The clinical efficacy of antiretroviral therapy in NeuroAIDS is primarily limited by the low perfusion drug to brain. objective current investigation was design and develop an situ mucoadhesive gel loaded with darunavir assess feasibility brain targeting through intranasal route. Preliminary batches (F1−F9) were prepared evaluated for various pharmaceutical characteristics. A full factorial experiment applied optimize effect two influencing variables (Carbopol 934P (X1) Poloxamer 407 (X2))...
This study explores the synthesis and crystallographic characterization of eight thieno[2,3-d]pyrimidines derivatives. Keeping in mind their practical importance different biological applications, understanding crystal structure terms...
Two series of 2-substituted aryl, heteroaryl and alkyl, 4-substituted aryl 1,3-oxazole (2a-k) thiazole (4a-k) molecular scaffolds containing divalent bioisosteres, viz., oxygen sulphur were synthesized by condensing substituted amides thioamides with phenacyl bromide in absolute ethanol medium. The structure newly compounds was characterized analytical spectral (IR, 1H-NMR, 13C-NMR LC-MS) methods. evaluated for qualitative (zone inhibition) quantitative antibacterial activity (MIC) agar cup...
The aim of this study was to design, optimize, and develop metronidazole (Met) loaded nanoparticles (MetNp) by employing quality-based design (QbD) as well a risk assessment methodology. A fractional factorial used selecting five independent variables viz., chitosan concentration, tripolyphosphate acetic acid concentration material attributes, stirring speed, time process parameters, whereby their influence on two dependent such particle size (PS) %entrapment efficiency (%EE) studied. MetNp...
Being a biopharmaceutics classification system class II drug, the absorption of sertraline from gut is mainly limited by its poor aqueous solubility. The objective this investigation was to improve solubility utilizing self-nanoemulsifying drug delivery systems (SNEDDS) and developing it into tablet dosage form. Ternary phase diagrams were created identify nanoemulsion regions fixing oil (glycerol triacetate) water while varying surfactant (Tween 80) co-surfactant (PEG 200) ratio (Smix). A...