A5060843606- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Optical Coherence Tomography Applications
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Photoacoustic and Ultrasonic Imaging
- Retinal Development and Disorders
- Peripheral Artery Disease Management
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Acute Ischemic Stroke Management
- Radiomics and Machine Learning in Medical Imaging
- Advanced Fluorescence Microscopy Techniques
- Law, logistics, and international trade
- Retinal and Macular Surgery
- Renal and Vascular Pathologies
- Medical Image Segmentation Techniques
- Ion Channels and Receptors
- Systemic Lupus Erythematosus Research
- Lipid metabolism and disorders
- AI in cancer detection
- Ear Surgery and Otitis Media
Oregon Health & Science University
2015-2019
Roche (United States)
2019
Roche (Switzerland)
2019
American Academy of Ophthalmology
2017
Choroideremia Research Foundation
2016
Foundation Fighting Blindness
2016
Prevent Blindness
2015-2016
Research to Prevent Blindness
2015-2016
Rice University
2009-2015
Stanford University
2011-2015
Significance Retinal vascular diseases are a leading cause of blindness. Optical coherence tomography (OCT) has become the standard imaging modality for evaluating fluid accumulation in these and guiding treatment. However, fluorescein angiography (FA) is still required initial evaluation retinal ischemia choroidal neovascularization, which not visible conventional structural OCT. The limitations FA include poor penetration fluorescence through blood pigment, inability to determine depth...
In Brief Purpose: To describe the optical coherence tomography angiography features of diabetic retinopathy. Methods: Using a 70 kHz and split-spectrum amplitude decorrelation algorithm, 6 mm × 3-dimensional angiograms macula 4 patients with retinopathy were obtained compared fluorescein for cataloged by Early Treatment Diabetic Retinopathy Study. Results: Optical detected enlargement distortion foveal avascular zone, retinal capillary dropout, pruning arteriolar branches. Areas loss...
Macular ischemia is a key feature of diabetic retinopathy (DR). Quantification macular has potential as biomarker for DR.To assess the feasibility automated quantification capillary nonperfusion sign using optical coherence tomography (OCT) angiography.An observational study conducted in tertiary, subspecialty, academic practice evaluated with 6 × 6-mm OCT angiography obtained commercially available 70-kHz and fluorescein (FA). The was from January 22 to September 18, 2014. Data analysis...
Despite the development of effective therapies, a substantial proportion asthmatics continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient receptor potential cation channel member A1 (TRPA1) agonists are elevated in human asthmatic airways, rodents, TRPA1 is involved induction airway inflammation hyperreactivity. Here, discovery early clinical GDC-0334, highly potent, selective, orally bioavailable antagonist, described. GDC-0334 inhibited function on smooth...
In Brief Purpose: To evaluate eyes with age-related macular degeneration and high-risk characteristics for choroidal neovascularization (CNV) optical coherence tomographic (OCT) angiography to determine whether earlier detection of CNV is possible. Methods: Eyes drusen, pigmentary changes, in the fellow eye were scanned a 70-kHz spectral domain OCT system (Optovue RTVue-XR Avanti). The split-spectrum amplitude-decorrelation (SSADA) algorithm was used distinguish blood flow from static...
Given the frequent use of improvised explosive devices (IEDs) around world, study traumatic blast injuries is increasing interest. The ear most common organ affected by injury because it body’s sensitive pressure transducer. We fabricated a chamber to re-create profiles similar that IEDs and used develop reproducible mouse model blast-induced hearing loss. tympanic membrane was perforated in all mice after exposure found heal spontaneously. Micro-computed tomography demonstrated no evidence...
This article provides an overview of advanced image processing for three dimensional (3D) optical coherence tomographic (OCT) angiography macular diseases, including age-related degeneration (AMD) and diabetic retinopathy (DR). A fast automated retinal layers segmentation algorithm using directional graph search was introduced to separates 3D flow data into different in the presence pathologies. Intelligent manual correction methods are also systematically addressed which can be done rapidly...
Artifacts introduced by eye motion in optical coherence tomography angiography (OCTA) affect the interpretation of images and quantification parameters with clinical value. Eradication such artifacts OCTA remains a technical challenge. We developed an algorithm that recognizes five different types used it to evaluate performance three removal technologies. On en face maximum projection flow images, summed signal each row column correlation between neighboring rows columns were calculated....
Purpose.: To measure the change in peripapillary retinal blood flow response to hyperoxia by using optical coherence tomography (OCT) angiography. Methods.: One eye of each healthy human participants (six) was scanned with a commercial high-speed (70 kHz) spectral OCT. Scans were captured twice after 10-minute exposures normal breathing (baseline) and hyperoxia. Blood detected split-spectrum amplitude-decorrelation angiography (SSADA) algorithm. Peripapillary index vessel density calculated...
The split-spectrum amplitude-decorrelation angiography algorithm was optimized on a spectral optical coherence tomography system using flow phantom. number of times the spectrum split and bandwidth each were adjusted to maximize phantom decorrelation signal-to-noise ratio. improvement in detection then demonstrated with en face retinal angiograms. increased detectable microvascular decreased variability quantified vessel density OCT angiograms healthy human subjects.
The tonotopic map of the mammalian cochlea is commonly thought to be determined by passive mechanical properties basilar membrane. other tissues and cells that make up organ Corti also have properties; however, their roles are less well understood. In addition, active forces produced outer hair (OHCs) enhance vibration membrane, termed cochlear amplification. Here, we studied how these biomechanical components interact using optical coherence tomography, which permits vibratory measurements...
Optical coherence tomography angiography has recently been used to visualize choroidal neovascularization (CNV) in participants with age-related macular degeneration. Identification and quantification of CNV area is important clinically for disease assessment. An automated algorithm detection presented this article. It relies on denoising a saliency model overcome issues such as projection artifacts the heterogeneity CNV. Qualitative quantitative evaluations were performed scans 7...
We observed and analyzed the morphologic characteristics of polypoidal lesions abnormal branching vascular network (BVN) in patients with choroidal vasculopathy (PCV) by optical coherence tomography angiography (OCTA).A retrospective observational case series was done PCV. All were scanned a 70-kHz spectral-domain OCT system using split-spectrum amplitude-decorrelation (SSADA) algorithm to distinguish blood flow from static tissue. The OCTA images these compared those indocyanine green...
Purpose: To compensate for reflectance variation when quantifying vessel density by optical coherence tomography angiography (OCTA). Methods: Healthy participants received 6×6-mm macular and 4.5×4.5-mm optic nerve head (ONH) scans on a 70-kHz spectral-domain system. The split-spectrum amplitude-decorrelation (SSADA) algorithm was used to compute the OCTA signal. Mean projection maximum decorrelation were create en face OCT images. Background noise in static tissue evaluated foveal avascular...
Sound transduction within the auditory portion of inner ear, cochlea, is a complex nonlinear process. The study cochlear mechanics in large rodents has provided important insights into function. However, technological and experimental limitations have restricted studies mice due to their smaller cochlea. These challenges are overcome because wide variety transgenic mouse strains with hearing loss mutations that available for study. To accomplish this goal, we used spectral domain optical...
The outer hair cell (OHC) motor protein prestin is necessary for electromotility, which drives cochlear amplification and produces exquisitely sharp frequency tuning. TectaC1509G transgenic mice have hearing loss, surprisingly increased OHC levels. We hypothesized, therefore, that up-regulation may represent a generalized response to compensate state of loss. In the present study, we sought determine effects noise-induced loss on expression. After noise exposure, performed cytocochleograms...
Novel therapies for choroideremia, an X-linked recessive chorioretinal degeneration, demand a better understanding of the primary site(s) cellular degeneration. Optical coherence tomography angiography allows choriocapillaris (CC) imaging. We compared extent structural alterations CC, retinal pigment epithelium, and photoreceptors with multimodal imaging.In clinical case series conducted from September 15, 2014, through February 5, 2015, 14 eyes 7 male patients choroideremia (median age, 34...
To develop deep learning models for annualized geographic atrophy (GA) growth rate prediction using fundus autofluorescence (FAF) images and spectral-domain OCT volumes from baseline visits, which can be used prognostic covariate adjustment to increase power of clinical trials.This retrospective analysis estimated GA as the slope a linear fit on all available measurements lesion area over 2-year period. Three multitask models-FAF-only, OCT-only, multimodal (FAF OCT)-were developed predict...
PurposeTo assess different microperimetry (MP) macular sensitivity outcome measures capturing functional deterioration in eyes with geographic atrophy (GA) secondary to age-related degeneration (AMD).DesignPatients were included from two identically designed, phase 3, double-masked, randomized controlled clinical trials, Chroma (NCT02247479) and Spectri (NCT02247531).Subjects, Participants, and/or ControlsPatients enrolled aged ≥50 years bilateral GA no evidence of previous or active...