A5044228668- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Advanced Biosensing Techniques and Applications
- Molecular Biology Techniques and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Wnt/β-catenin signaling in development and cancer
- Chronic Lymphocytic Leukemia Research
- RNA regulation and disease
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- PI3K/AKT/mTOR signaling in cancer
- Liver physiology and pathology
- Cytokine Signaling Pathways and Interactions
- Cancer Research and Treatments
- Mechanisms of cancer metastasis
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
- Ion Channels and Receptors
- Respiratory and Cough-Related Research
Despite the development of effective therapies, a substantial proportion asthmatics continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient receptor potential cation channel member A1 (TRPA1) agonists are elevated in human asthmatic airways, rodents, TRPA1 is involved induction airway inflammation hyperreactivity. Here, discovery early clinical GDC-0334, highly potent, selective, orally bioavailable antagonist, described. GDC-0334 inhibited function on smooth...
The fibroblast growth factor (FGF)-FGF receptor (FGFR) signaling system plays critical roles in a variety of normal developmental and physiological processes. It is also well documented that dysregulation FGF-FGFR may have important tumor development progression. FGFR4–FGF19 axis has been implicated the hepatocellular carcinomas (HCCs) mice, potentially humans. In this study, we demonstrate FGFR4 required for hepatocarcinogenesis; progeny FGF19 transgenic which previously shown to develop...
Primary liver cancer encompasses both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). The Notch signaling pathway, known to be important for the proper development of architecture, is also a potential driver primary cancer. However, with four receptors several ligands, it not clear which pathway members play predominant role in To address this question, we utilized antibodies specifically target Notch1, Notch2, Notch3, or jagged1 (Jag1) mouse model driven by v-akt murine thymoma...
Fibroblast growth factors (FGF) play important roles in development, angiogenesis, and cancer. FGF19 uniquely binds to FGF receptor 4 (FGFR4). Our previous study has shown that transgenic tumors have an activated Wnt-pathway phenotype. Wnt signaling is implicated initiating or promoting various cell types organs. In this study, we examined whether inhibition of affects the beta-catenin pathway using human colon cancer lines (HCT116, Colo201). results show increases tyrosine phosphorylation...
Antisense oligonucleotide (ASO) therapeutics are being investigated for a broad range of neurological diseases. While ASOs have been effective in the clinic, improving productive ASO internalization into target cells remains key area focus field. Here, we how delivery ASO-loaded lipid nanoparticles (LNPs) affects activity, subcellular trafficking, and distribution brain. We show that ASO-LNPs increase activity up to 100-fold cultured primary brain as compared non-encapsulated ASO. However,...
Fibroblast growth factor 19 (FGF19) represses cholesterol 7α-hydroxylase (Cyp7α1) and inhibits bile acid synthesis in vitro vivo. Previous studies have shown that anti-FGF19 antibody treatment reduces of colon tumor xenografts prevents hepatocellular carcinomas FGF19 transgenic mice thus may be a useful cancer target. In repeat dose safety study cynomolgus monkeys, (3-100 mg/kg) demonstrated dose-related liver toxicity accompanied by severe diarrhea low food consumption. The mechanism was...
Significance Statement Specific variants of APOL1, G1 and G2, are associated with CKD in the Black population. Overexpression these kills cells, through different proposed mechanisms subcellular compartments. The localization endogenous APOL1 has not been conclusively established because all studies have used antibodies that crossreact APOL2. Generation use APOL1-specific show podocyte localizes mainly inside endoplasmic reticulum, a few molecules on cell surface. These findings potentially...
The deubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with high risk of mesothelioma and melanocytic tumors. Here, we show that Bap1 deletion melanocytes cooperates the constitutively active, oncogenic form BRAF (BRAFV600E ) UV to cause melanoma mice, albeit at very low frequency. In addition, Bap1-null cells derived from mouse tumors are more aggressive colonize grow distant sites than their wild-type counterparts. Molecularly, cell lines have increased DNA damage...
Abstract Ovarian cancer is a diverse class of tumors with very few effective treatment options and suboptimal response rates in early clinical studies using immunotherapies. Here we describe LY6/PLAUR domain containing 1 (LYPD1) as novel target for therapeutic antibodies the ovarian cancer. LYPD1 broadly expressed both primary metastatic ∼70% prevalence serous subset. Bispecific targeting CD3 on T cells tumor antigen have demonstrated significant activity hematologic cancers. We developed an...
Positive and negative controls with known expression of target proteins are essential for the development immunohistochemistry (IHC) assays. While tissue beneficial well-characterized defined cellular patterns, they less suitable initial IHC assays novel, poorly characterized, or ubiquitously expressed proteins. Alternatively, due to their standardized nature, cell pellets, including cancer lines protein transcript levels (e.g., high, medium, low expression), transfected over-expressing...
Positive and negative controls with known expression of target proteins are essential for the development immunohistochemistry (IHC) assays. While tissue beneficial well-characterized defined cellular patterns, they less suitable initial IHC assays novel, poorly characterized, or ubiquitously expressed proteins. Alternatively, due to their standardized nature, cell pellets, including cancer lines protein transcript levels (e.g., high, medium, low expression), transfected over-expressing...
<div>Abstract<p>Fibroblast growth factors (FGF) play important roles in development, angiogenesis, and cancer. FGF19 uniquely binds to FGF receptor 4 (FGFR4). Our previous study has shown that transgenic tumors have an activated Wnt-pathway phenotype. Wnt signaling is implicated initiating or promoting various cell types organs. In this study, we examined whether inhibition of affects the β-catenin pathway using human colon cancer lines (HCT116, Colo201). results show increases...
Supplementary Figure 1-8 from Inhibition of Fibroblast Growth Factor 19 Reduces Tumor by Modulating β-Catenin Signaling
Supplementary Figure 1-8 from Inhibition of Fibroblast Growth Factor 19 Reduces Tumor by Modulating β-Catenin Signaling
<div>Abstract<p>Ovarian cancer is a diverse class of tumors with very few effective treatment options and suboptimal response rates in early clinical studies using immunotherapies. Here we describe LY6/PLAUR domain containing 1 (LYPD1) as novel target for therapeutic antibodies the ovarian cancer. LYPD1 broadly expressed both primary metastatic ∼70% prevalence serous subset. Bispecific targeting CD3 on T cells tumor antigen have demonstrated significant activity hematologic...
<p>Supplementary Data</p>
<p>Supplementary Data</p>
<div>Abstract<p>Ovarian cancer is a diverse class of tumors with very few effective treatment options and suboptimal response rates in early clinical studies using immunotherapies. Here we describe LY6/PLAUR domain containing 1 (LYPD1) as novel target for therapeutic antibodies the ovarian cancer. LYPD1 broadly expressed both primary metastatic ∼70% prevalence serous subset. Bispecific targeting CD3 on T cells tumor antigen have demonstrated significant activity hematologic...
<div>Abstract<p>Fibroblast growth factors (FGF) play important roles in development, angiogenesis, and cancer. FGF19 uniquely binds to FGF receptor 4 (FGFR4). Our previous study has shown that transgenic tumors have an activated Wnt-pathway phenotype. Wnt signaling is implicated initiating or promoting various cell types organs. In this study, we examined whether inhibition of affects the β-catenin pathway using human colon cancer lines (HCT116, Colo201). results show increases...