A5102725615- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Cancer-related Molecular Pathways
- Gastric Cancer Management and Outcomes
- Gut microbiota and health
- Probiotics and Fermented Foods
- Tracheal and airway disorders
- Medical History and Innovations
- Intracranial Aneurysms: Treatment and Complications
- Gastroesophageal reflux and treatments
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Airway Management and Intubation Techniques
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Anesthesia and Sedative Agents
- Cancer Research and Treatments
- Ovarian cancer diagnosis and treatment
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- Dysphagia Assessment and Management
- Eosinophilic Esophagitis
Asahikawa Medical University
2023-2025
Nippon Medical School
2014-2024
Yakult Central Institute
2013-2024
Indiana University – Purdue University Indianapolis
2024
Indiana University School of Medicine
2024
Hamamatsu University School of Medicine
2011-2023
Hamamatsu University
2008-2022
Kyorin University Hospital
2012-2021
Hokkaido University
2020
Sapporo Science Center
2020
Colonization of the infant gut is believed to be critically important for a healthy growth as it influences maturation, metabolic, immune and brain development in early life. Understanding factors that influence this process important, since an altered colonization has been associated with higher risk diseases later Fecal samples were collected from 108 neonates first half year The composition functionality microbiota was characterized by measuring 33 different bacterial taxa qPCR/RT qPCR, 8...
Objectives Bifidobacterium species are one of the major components infant's intestine microbiota. Colonization with bifidobacteria in early infancy is suggested to be important for health later life. However, information remains limited regarding source these microbes. Here, we investigated whether specific strains maternal intestinal flora transmitted their intestine. Materials and Methods Fecal samples were collected from healthy 17 mother infant pairs (Vaginal delivery: 12; Cesarean...
The gastrointestinal tracts of neonates are colonized by bacteria immediately after birth. It has been discussed that the intestinal microbiota includes strains transferred from mothers. Although some studies have indicated possible bacterial transfer mother to newborn, this is first report confirming bifidobacteria at strain level. Here, we investigated mother-to-infant transmission Bifidobacterium longum subsp. genotyping isolates feces mothers before delivery and their infants delivery....
Systemic hypertension has long been considered a risk factor of aneurysmal rupture. However, causal link between systemic and the development rupture not established. In this study, using mouse model intracranial aneurysm rupture, we examined roles in rupture.Aneurysms were induced by combination deoxycorticosterone acetate (DOCA)-salt single injection elastase into cerebrospinal fluid mice. Antihypertensive treatment was started 6 days after induction. Aneurysmal detected neurological...
Aortic aneurysms are common among the elderly population. A large majority of aortic located at two distinct aneurysm-prone regions, abdominal aorta and thoracic involving ascending aorta. In this study, we combined factors that associated with human aneurysms, hypertension degeneration elastic lamina, to induce an aneurysm in mice. Roles hemodynamic conditions formation were assessed using different methods for inducing antihypertensive agents. 9-week-old C57BL/6J male mice, was induced by...
Gut microbiota modulates metabolic and immunoregulatory axes contributes to the pathophysiology of diseases with inflammatory components, such as atherosclerosis, diabetes mellitus, ischemic stroke. Inflammation is emerging a critical player in an intracranial aneurysm. Therefore, we hypothesized that gut affects aneurysm formation by modulating inflammation. We induced aneurysms mice combining systemic hypertension single injection elastase into cerebrospinal fluid. Depletion was achieved...
The value of various screening methods in the detection early hepatocellular carcinoma was investigated 95 patients with cirrhosis. Infusion hepatic angiography and computed tomography were performed yearly, ultrasound every 3 months, determination serum alpha-fetoprotein levels 2 months. "Space-occupying lesions" suspicious for found 13 cases (13.7%). Detection rates "space-occupying 77% infusion angiography, 54% ultrasonography, respectively. In 8 cases, subsequently confirmed as by...
Background and Purpose— An increasing number of unruptured intracranial aneurysms are being detected, partly due to the increased use brain imaging techniques. Pharmacological stabilization for prevention aneurysmal rupture could potentially be an attractive alternative approach clipping or coiling in patients with aneurysms. We have developed a mouse model aneurysm that recapitulates key features In this model, subarachnoid hemorrhage from causes neurological symptoms can easily detected by...
Clinical observations suggest that postmenopausal women have a higher incidence of aneurysmal rupture than premenopausal women. We hypothesize relative deficiency in estrogen may increase the risks growth and subarachnoid hemorrhage assessed effects selective receptor subtype agonists on development ovariectomized female mice. used an intracranial aneurysm mouse model recapitulates key features human aneurysms, including spontaneous rupture. Ten- to 12-week-old mice received treatment with...
Ovarian cancer remains the most lethal gynecologic and new targeted molecular therapies against this miserable disease continue to be challenging. In study, we analyzed expressional patterns of Interleukin-6 (IL-6) its receptor (IL-6R) expression in ovarian tissues, evaluated impact these expressions on clinical outcomes patients, found that a high-level IL-6R but not IL-6 cells is an independent prognostic factor. vitro analyses using cell lines, while six (RMUG-S, RMG-1, OVISE, A2780,...
Two novel micro-organisms, designated strains YIT 10443(T) and 10738, were isolated from airag, a traditional fermented mare's milk Mongolia. The two Gram-positive-staining, non-motile, asporogenous, catalase-negative, facultatively anaerobic rods of various shapes. Comparative analyses 16S rRNA ClpC ATPase (clpC) gene sequences the presence fructose-6-phosphate phosphoketolase (F6PPK) demonstrated that members genus Bifidobacterium. On basis sequence similarity, type Bifidobacterium minimum...
Epidemiological studies have indicated that postmenopausal women a higher incidence of intracranial aneurysms than men in the same age group.To investigate whether estrogen or receptors (ERs) mediate protective effects against formation aneurysms.Intracranial were induced mice by combining single injection elastase into cerebrospinal fluid with deoxycorticosterone acetate salt hypertension. The treated (17β-estradiol), an ERα agonist (propyl pyrazole triol), and ERβ (diarylpropionitrile)...
There are reports of p53 gene mutations in various human cancers but not rat tumor cell lines or primary tissue. We found a mutation line spontaneous squamous carcinoma the Zymbal gland, SCC131, at codon 171 by direct sequencing cDNA fragments amplified PCR. tested for 15 gland tumors induced 2-amino-3-methylimidazo[4,5-f]quinoline single-strand conformation polymorphism analysis PCR-amplified products. Samples four showed mobility shifts. Direct revealed that all these had conserved regions...
To develop a quick and accurate PCR-based method to evaluate viable Bifidobacterium breve strain Yakult (BbrY) in human faeces.The number of BbrY faeces was detected by using strain-specific quantitative real-time PCR (qPCR) derived from randomly amplified polymorphic DNA analysis. And propidium monoazide (PMA) treatment, which combined DNA-intercalating dye for covalently linking dead cells photoactivation, only the highly significantly correlated with added faecal samples within range...
In spite of the undisputed importance altered expression patterns microRNAs (miRNAs) in various cancers, there is little information on clinicopathologic significance cancer-related miRNAs (MIR21, MIR143, MIR144, MIR145, and MIR205) esophageal squamous cell carcinoma (ESCC). We examined levels precursor mature miRNA genes ESCC using real-time polymerase chain reaction (PCR). also investigated mRNA processing elements (RNASEN, DGCR8, DICER1) that participate miRNA-biogenesis pathway....
Bifidobacteria are considered to be one of the most important beneficial intestinal bacteria for infants, contributing priming mucosal immune system. These microbes can also detected in mother's milk, suggesting a potential role human milk colonisation infant's gut. However, little is known about timing appearance and whether first source inoculation. Here, we investigated specific strains shared sustainably between maternal Faecal samples were collected from 102 healthy mother-infant pairs...
Abstract Aim The purpose of this study was to evaluate the efficacy diffusion‐weighted ( DW ) magnetic resonance MR imaging predict tumor response chemoradiotherapy CRT uterine cervical cancer. Methods Twenty‐five consecutive patients with pathologically confirmed cancer underwent 1.5‐ T including before and during . images were reviewed for size apparent diffusion coefficient ADC ). Pathological evaluation therapeutic effect performed 3 months after finishing , we divided subjects into two...
A Gram-positive-staining, coccoid-shaped, non-motile, asporogenous, obligately anaerobic and butyrate-producing bacterium was recovered from a healthy human's faeces. The organism isolated by the enrichment culture technique using yeast extract-casein hydrolysate-fatty acids broth supplemented with 0.5 % mucin. Phylogenetic analysis of 16S rRNA gene sequences demonstrated that novel strain should be classified as member Eubacterium desmolans-related cluster in family Ruminococcaceae....
Remimazolam is a novel ultrashort-acting benzodiazepine that has recently become available for general anesthesia. However, the incidence of postoperative nausea and vomiting (PONV) associated with remimazolam remains unknown. In this propensity score-matched, retrospective, observational study, we compared rates PONV between propofol.In retrospective score-matching was performed to minimize selection bias. Patients who received total intravenous anesthesia or propofol at Hamamatsu...