A5011891860- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Voice and Speech Disorders
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Sleep and Wakefulness Research
- Cardiovascular Syncope and Autonomic Disorders
- Sleep and related disorders
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Cerebral Venous Sinus Thrombosis
- Respiratory and Cough-Related Research
- Vestibular and auditory disorders
- Head and Neck Surgical Oncology
- Soft tissue tumor case studies
- Cerebral Palsy and Movement Disorders
- Cervical Cancer and HPV Research
- Infection Control and Ventilation
- Sarcoma Diagnosis and Treatment
- Healthcare Systems and Challenges
- Endometrial and Cervical Cancer Treatments
- Restless Legs Syndrome Research
- Sinusitis and nasal conditions
- COVID-19 and healthcare impacts
- Viral-associated cancers and disorders
University of Miami Health System
2024-2025
University of Miami
2022-2025
Cornell University
2015-2023
Weill Cornell Medicine
2017-2023
New York Hospital Queens
2016-2022
Presbyterian Hospital
2017-2022
NewYork–Presbyterian Hospital
2016-2022
GTx (United States)
2021
In-Q-Tel
2021
National Institute for Health Development
2021
To determine the association between findings of blinded reviews preoperative drug-induced sleep endoscopy (DISE) and outcomes hypoglossal nerve stimulation (HNS) for obstructive apnea (OSA).Cohort study.A retrospective, multicenter cohort study 343 adults who underwent treatment OSA with HNS from 10 academic medical centers was performed. Preoperative DISE videos were scored by four reviewers using VOTE Classification evaluation a possible primary structure contributing to airway...
Objective Evaluate the role of venous sinus stenting in treatment pulsatile tinnitus among patients with Idiopathic Intracranial Hypertension (IIH) and significant stenosis. Subjects Methods A written informed consent approved by Weill Cornell institutional review board was signed obtained from study participants. Thirty-seven consecutive IIH stenosis who were treated between Jan.2012-Jan.2016 prospectively evaluated. Patients without excluded. Tinnitus severity categorized based on...
Objectives/Hypothesis To provide the ADHERE registry Upper Airway Stimulation (UAS) outcomes update, including analyses grouped by body mass index (BMI) and therapy discomfort. Study Design Prospective observational study. Methods captures UAS apnea‐hypopnea (AHI), Epworth sleepiness scale (ESS), usage, patient satisfaction, clinician assessment, safety over a 1‐year period. BMI ≤32 kg/m 2 (BMI 32 ) < ≤35 35 group were examined. Results One thousand eight hundred forty‐nine patients...
Objectives/Hypothesis Upper airway stimulation (UAS) is an effective treatment for obstructive sleep apnea (OSA). Previous data have demonstrated a correlation between the phenotype of tongue motion and therapy response. Closed loop hypoglossal nerve implant offers five different electrode configuration settings which may result in motion. Study Design Two‐center, prospective consecutive trial university hospital setting. Methods Clinical outcomes 35 patients were analyzed after at least 12...
Objectives/Hypothesis The goal of this study was to evaluate the prevalence mucosal contact points (MCP), concha bullosa (CB), and variable paranasal sinus (PNS) volumes among patients sent for rhinogenic headache workup as compared with controls. Study Design Retrospective case control groups. Methods Fifty‐three adults clear PNS computed tomography (CT) scans were included: 28 who have originally undergone CT scan part (rhinogenic) workup, 25 controls in whom obtained other purposes. All...
Hypoglossal nerve stimulation (HGNS) has evolved as a novel and effective therapy for patients with moderate-to-severe obstructive sleep apnea. Despite positive published outcomes of HGNS, there exist uncertainties regarding proper patient selection, surgical technique, the reporting individual factors that impact effectiveness. According to current guidelines, this is indicated select patients, recommendations are based on Stimulation Therapy Apnea Reduction or STAR trial. Ongoing research...
Objective We aimed to determine the preoperative prevalence of insomnia in Adherence and Outcomes Upper Airway Stimulation for OSA International Registry (ADHERE) examine serial sleep‐related data longitudinally, particular Insomnia Severity Index (ISI), compare outcomes between patients with no/subthreshold (ISI < 15) moderate/severe ≥ at baseline. Methods analyzed observational from ADHERE March 2020 September 2022. Baseline demographic mental health (MH) data, apnea hypopnea index...
Abstract Hypoglossal nerve stimulation has become an increasingly popular treatment for obstructive sleep apnea. Some patients express concerns about the appearance of anterior chest incision scar. Here, we describe feasibility lateral axillary approach placing fifth‐generation implantable pulse generator, which does not require a respiratory sensor. The first three were successfully implanted, had excellent waveforms, and no complications. surgical times substantially different than...
Ischemia and sepsis lead to endothelial cell damage, resulting in compromised microvascular flow many organs. Much remains be determined regarding the intracellular structural events that dysfunction. To investigate potential actin cytoskeletal-related mechanisms, ATP depletion was induced mouse pancreatic cells (MS1). Fluorescent imaging biochemical studies demonstrated a rapid progressive increase F-actin along with decrease G-actin at 60 min. Confocal microscopic analysis showed resulted...
Upper airway stimulation (UAS) is an effective second-line treatment for obstructive sleep apnea (OSA). In certain patients, there a considerable need advanced programming, notably with inadequate palatal response to therapy. The aim of the study was investigate impact uvulopalatopharyngoplasty and tonsillectomy (UPPP-TE) on UAS therapy outcomes from 2-year perspective after implantation.This included all consecutive patients implanted in which full set 1- follow-up assessments (M12 M24)...
Objectives/Hypothesis Upper airway stimulation for obstructive sleep apnea (OSA) via implantable hypoglossal nerve (HGNS) reduces obstruction by selectively stimulating fibers that innervate muscles produce tongue protrusion, while avoiding retraction. This selective likely depends upon the location, intensity, and type of electrical delivered. study investigates impact changing parameters on muscle activation during HGNS using intraoperative integrity monitoring in conjunction with...
This prospective study evaluates the effectiveness and safety of venous sinus stenting for patients with isolated pulsatile tinnitus lateral stenosis.Patients stenosis a minimum trans stenotic gradient 4 mm Hg were treated stenting. Pulsatile before after treatment was assessed Tinnitus Handicap Inventory (THI). Periprocedural adverse events, neurological complications, clinical radiographic follow-up also recorded.A total 42 (41 females 1 male) included in (median age 37.5 years). Thirty...
Abstract Introduction Obstructive sleep apnea (OSA), the most common sleep-related breathing disorder, has various treatment options. Recently, GLP-1 and GLP-1/GIP receptor agonists have been approved to treat obesity found successfully improve associated OSA. Our study aims evaluate impact of incretins on patients with OSA whether these anti-obesity medications are effective as standalone treatments or require hypoglossal nerve stimulation (HNS) optimize management. Methods A comparative...
Abstract Introduction The Dual-sided hypoglossal neRvE stimulAtion for the treatMent of obstructive sleep apnea (DREAM) trial is a prospective, multicenter study evaluating safety and efficacy bilateral nerve stimulation (HNSBL) in (OSA) patients with moderate severe OSA. Methods A prospective non-randomized moderate-to-severe OSA (AHI4% 15.1-64.9 hr), body mass index ≤32 kg/m2, lack complete concentric palatal collapse during drug-induced endoscopy who failed or refused positive airway...
Abstract Introduction Continuous Positive Airway Pressure (CPAP) therapy is the cornerstone of treatment for obstructive sleep apnea (OSA). However, higher pressure settings can occasionally lead to unexpected complications. This case highlights importance careful titration while treating OSA, particularly in patients experiencing ear-related symptoms. Report A 74-year-old male with a history coronary artery disease and moderate OSA (REI 22.9/hour) presented left ear discomfort exacerbated...
The effectiveness of hypoglossal nerve stimulation (HGNS) in the treatment obstructive sleep apnea (OSA) depends on selective fibers that innervate tongue muscles produce protrusion (genioglossus) and stiffening (transverse/vertical) while avoiding retraction (styloglossus/hyoglossus). Postoperative failures can be related to mixed activation retractor protrusor muscles, despite intraoperative efforts identify avoid muscles. This study describes a novel protocol more optimally identifies by...
Objective Despite the increase of women in surgical fields and resources toward advancing women, there is no corresponding increased representation higher academic ranks leadership. The following hypotheses are explored: 1) men build/maintain different relationship networks 2) not similarly included within organization do receive same sponsorship as male counterparts. Study Design Prospective observational study. Methods Three months prospective, passive organizational network data full‐time...
We present three adults with Down syndrome and obstructive sleep apnea (OSA) treated hypoglossal nerve stimulation. The average age of these males was 37.3 years. All patients had severe OSA on polysomnography. Postimplantation titration studies exhibited residual according to total apnea-hypopnea index (AHI), but there were significant reductions (86%-100%) in the titrated AHI at ideal device setting. Morbidity surgery low, excellent adherence, an 57.3 hours/week. reported subjective...
The only hypoglossal nerve stimulation (HNS) device available for US clinical use is implanted through 3 incisions. A recently proposed 2-incision modification moved the respiratory sensing lead from fifth to second intercostal space eliminate third lower chest incision. This study compared perioperative data and therapeutic outcomes between techniques.Noninferiority cohort analysis of a retrospective prospective registry study.Tertiary care community surgical centers.Patients with...
The sublingual mucosa has been used for many years to apply allergenic extracts the purpose of specific immunotherapy (IT). Although IT (SLIT) is both safe and efficacious, density antigen-presenting cells higher in other regions oral cavity vestibule, which make them a potentially desirable target IT.To present concept mucosal (OMIT) provide pilot data this extended application SLIT.An open-label, 12-month, prospective study was undertaken as preliminary step before full-scale clinical...
Abstract Study Objectives Individuals with obstructive sleep apnea (OSA), characterized by frequent disruptions from tongue muscle relaxation and airway blockage, are known to benefit on-demand electrical stimulation of the hypoglossal nerve. Hypoglossal nerve (HNS) therapy, which activates protrusor muscles during inspiration, has been established in multiple clinical studies as safe effective, but mechanistic understanding for why some parameters work better than others not thoroughly...